Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. [PDF]
PLoS ONE, 2013 The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the precise roles of the individual Wnt co-receptors, Lrp5 and Lrp6, that enable Wnt signals to be transmitted in osteoblasts remain controversial.
Ryan C Riddle +6 more
doaj +1 more source
Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]
, 2019 Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana +5 more
core +1 more source
Modulation of β-catenin signaling by glucagon receptor activation. [PDF]
PLoS ONE, 2012 The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Activation of GCGR by glucagon leads to increased glucose production by the liver.
Jiyuan Ke +8 more
doaj +1 more source
Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer [PDF]
, 2015 Introduction Aromatase inhibitors (AIs) are a vital component of estrogen receptor positive (ER+) breast cancer treatment. De novo and acquired resistance, however, is common.
A Mackay +65 more
core +3 more sources
LRP5 and Wnt Signaling: A Union Made for Bone [PDF]
Journal of Bone and Mineral Research, 2004 THE IDENTIFICATION OF mutations in the human lowdensity lipoprotein (LDL) receptor–related protein 5 (LRP5) gene that give rise to conditions of low bone mass and increased bone mass has brought what just a few years ago were two seemingly unrelated fields crashing together, namely bone biology and Wnt signaling.
Johnson, Mark L. +3 more
openaire +4 more sources
The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review [PDF]
, 2015 published_or_final_versio
Cao, F +11 more
core +9 more sources
Polymorphism in LRP5 (rs556442) is associated with higher TG levels in Iranian children
Annals of Human Biology, 2017 Background: Wnt signalling/LRP5 is involved in adipogenesis by down-regulating adipogenic transcription factors. Therefore polymorphisms in components of this pathway may lead to metabolic disorders. Aim: This study tested the impact of LRP5 polymorphism
Nima Montazeri-Najafabady +4 more
doaj +1 more source
The regulation of differentiation in mesenchymal stem cells [PDF]
, 2010 Peer reviewedPublisher ...
Augello, Andrea, De Bari, Cosimo
core +1 more source
PCSK9 and LRP5 in macrophage lipid internalization and inflammation
Cardiovascular Research, 2020 Abstract Aims Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. Low-density lipoprotein receptors (LDLR) play a critical role in regulating blood cholesterol levels by binding to and clearing LDLs from the circulation ...
Lina Badimon +4 more
openaire +4 more sources
High-bone-mass causing mutant LRP5 receptors are resistant to endogenous inhibitors in vivo [PDF]
, 2015 Certain missense mutations affecting LRP5 cause high bone mass (HBM) in humans. Based on in vitro evidence, HBM LRP5 receptors are thought to exert their effects by providing resistance to binding/inhibition of secreted LRP5 inhibitors such as sclerostin
Bellido, Teresita +7 more
core +1 more source