Results 51 to 60 of about 21,385 (242)

Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. [PDF]

PLoS ONE, 2013
The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the precise roles of the individual Wnt co-receptors, Lrp5 and Lrp6, that enable Wnt signals to be transmitted in osteoblasts remain controversial.
Ryan C Riddle, Cassandra R Diegel, Julie M Leslie, Kyle K Van Koevering, Marie-Claude Faugere, Thomas L Clemens, Bart O Williams   +6 more
doaj   +1 more source

How accurate is your sclerostin measurement?:Comparison between three commercially available sclerostin ELISA kits [PDF]

, 2016
Sclerostin, bone formation antagonist is in the spotlight as a potential biomarker for diseases presenting with associated bone disorders such as chronic kidney disease (CDK-MBD). Accurate measurement of sclerostin is therefore important.
Fisher, Emily, Fraser, William D, Greeves, Julie, Jackson, Sarah, Piec, Isabelle, Tang, Jonathan, Washbourne, Christopher   +6 more
core   +1 more source

High-bone-mass causing mutant LRP5 receptors are resistant to endogenous inhibitors in vivo [PDF]

, 2015
Certain missense mutations affecting LRP5 cause high bone mass (HBM) in humans. Based on in vitro evidence, HBM LRP5 receptors are thought to exert their effects by providing resistance to binding/inhibition of secreted LRP5 inhibitors such as sclerostin
Bellido, Teresita, He, Xi, Kedlaya, Rajendra, MacDonald, Bryan T., Niziolek, Paul J., Robling, Alexander G., Warman, Matthew L., Zhang, Minjie   +7 more
core   +1 more source

LRP5 sequence and polymorphisms in the baboon [PDF]

Journal of Medical Primatology, 2009
AbstractBackground  LRP5 is known to have an important relationship with bone density and a variety of other biological processes. Mapping to human chromosome 11q13.2, LRP5 shows considerable evolutionary conservation. Orthologs of this gene exist in many species, although comparison of human LRP5 with other non‐human primates has not been performed ...
Alison F, Doubleday, Frederika A, Kaestle, Laura A, Cox, Shifra, Birnbaum, Michael C, Mahaney, Lorena M, Havill   +5 more
openaire   +2 more sources

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. [PDF]

, 2015
Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types.
Baday, Yiressy C, Bao, Ju, Guibao, Cristina, Lee, Ho-Jin, Li, Lin, Miller, Ami, Wu, Dianqing, Wu, Jibo, Zhang, Chi, Zheng, Jie J   +9 more
core   +2 more sources

An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. [PDF]

PLoS Medicine, 2007
BACKGROUND: Hyperparathyroidism (HPT) is a common endocrine disorder with incompletely understood etiology, characterized by enlarged hyperactive parathyroid glands and increased serum concentrations of parathyroid hormone and ionized calcium.
Peyman Björklund, Göran Akerström, Gunnar Westin   +2 more
doaj   +1 more source

Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass Cases. [PDF]

, 2015
High bone mass (HBM) can be an incidental clinical finding; however, monogenic HBM disorders (eg, LRP5 or SOST mutations) are rare. We aimed to determine to what extent HBM is explained by mutations in known HBM genes.
Addison, Kathryn A, Agarwal, Rohan, Appleton, Louise H, Brown, Matthew A, Brugmans, Marieke, Bullock, Alex N, Clark, Graeme R, Davey Smith, George, Duncan, Emma L, Fraser, William D, Gregson, Celia L, Hardcastle, Sarah A, McCloskey, Eugene, Paggiosi, Margaret, Poole, Kenneth ES, Stone, Mike, Thomas, Joegi, Tobias, Jon H, Ward, Kate A, Wheeler, Lawrie, Williams, Eleanor   +20 more
core   +7 more sources

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer [PDF]

, 2016
Tumor–stroma interactions contribute to tumorigenesis. Tumor cells can educate the stroma at primary and distant sites to facilitate the recruitment of heterogeneous populations of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs).
Ali Zamani, Andrea Wang-Gillam, Aude-Hélène Capietto, Barcellos-Hoff, Biancamaria Ricci, Bindea, Capietto, David B. Bumpass, David G. DeNardo, Fowler, Gabitass, Gabrilovich, Gabrilovich, Galon, Hamanishi, Katherine Weilbaecher, Li, Liu, Lucia D’Amico, MacDonald, Mace, Mahmoud, Melissa Meyer, Mitchem, Mundy-Bosse, Pinzone, Porembka, Roberta Faccio, Räsänen, Sahil Mahajan, Schreiber, Sheila A. Stewart, Tian, Trikha, Weilbaecher, Xinming Su, Yaccoby, Yamabuki, Yang, Zhang, Zhang, Zheng, Zhengfeng Yang, Zhu   +43 more
core   +2 more sources

LRP5 and Wnt Signaling: A Union Made for Bone [PDF]

Journal of Bone and Mineral Research, 2004
THE IDENTIFICATION OF mutations in the human lowdensity lipoprotein (LDL) receptor–related protein 5 (LRP5) gene that give rise to conditions of low bone mass and increased bone mass has brought what just a few years ago were two seemingly unrelated fields crashing together, namely bone biology and Wnt signaling.
Johnson, Mark L., Harnish, Kimberley, Nusse, Roel, Van Hul, Wim   +3 more
openaire   +3 more sources

Sp1 and KLF15 regulate basal transcription of the human LRP5 gene

BMC Genetics, 2010
Background LRP5, a member of the low density lipoprotein receptor superfamily, regulates diverse developmental processes in embryogenesis and maintains physiological homeostasis in adult organisms.
Zou Yongxin, Zhang Xiyu, Jiang Baichun, Yang Yang, Li Jiangxia, Gong Yaoqin   +5 more
doaj   +1 more source