Results 61 to 70 of about 21,385 (242)
LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]
PLoS Pathogens, 2007 Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young +8 more
doaj +1 more source
Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]
, 2018 Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António +7 more
core +4 more sources
Advanced Healthcare Materials, EarlyView.Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach +7 more
wiley +1 more source
BMC Gastroenterology, 2022 Background Multiple studies have demonstrated the involvement of low-density lipoprotein receptor-related protein 5 (LRP5) in metabolism-related diseases.
Dongli Han +6 more
doaj +1 more source
Advanced Science, EarlyView.The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu +16 more
wiley +1 more source
Advanced Science, EarlyView.Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang +27 more
wiley +1 more source
The role of Lrp5/6 in cardiac valve disease: Experimental hypercholesterolemia in the ApoE−/−/Lrp5−/− mice [PDF]
Journal of Cellular Biochemistry, 2011 Lrp5/6 co-receptor is known to play a role in bone formation and lipid metabolism. This gene encodes a member of the low-density lipoprotein (LDL) receptor gene family. This study tests the hypothesis that Lrp5/6 is necessary for the development of valve calcification in experimental hypercholesterolemia.
openaire +2 more sources
Advanced Science, EarlyView.PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang +7 more
wiley +1 more source
Assessment of genes LRP5, BVP4, TGF^l polymorphisms significance in postmenopausal osteoporosis
Научно-практическая ревматология, 2008 180 women with primary postmenopausal osteoporosis (OP) (mean age 67,5+7,8 years) were included. 118 postmenopausal women without osteoporosis and osteopenia (mean age 63,8±8,1 years) formed control group.
KA Myakotkin +6 more
doaj +1 more source
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, EarlyView.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source