Results 61 to 70 of about 20,422 (245)
Assessment of genes LRP5, BVP4, TGF^l polymorphisms significance in postmenopausal osteoporosis
Научно-практическая ревматология, 2008 180 women with primary postmenopausal osteoporosis (OP) (mean age 67,5+7,8 years) were included. 118 postmenopausal women without osteoporosis and osteopenia (mean age 63,8±8,1 years) formed control group.
KA Myakotkin +6 more
doaj +1 more source
Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan +4 more
core +2 more sources
An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. [PDF]
PLoS Medicine, 2007 BACKGROUND: Hyperparathyroidism (HPT) is a common endocrine disorder with incompletely understood etiology, characterized by enlarged hyperactive parathyroid glands and increased serum concentrations of parathyroid hormone and ionized calcium.
Peyman Björklund +2 more
doaj +1 more source
Advanced Materials, EarlyView.This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang +3 more
wiley +1 more source
Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts. [PDF]
PLoS ONE, 2017 Wnt3a is a major regulator of bone metabolism however, very few of its target genes are known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and co-receptors Lrp5/6 to activate the canonical signaling pathway.
Aimy Sebastian +5 more
doaj +1 more source
Wnt5a Signaling in Normal and Cancer Stem Cells. [PDF]
, 2017 Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner.
Kipps, Thomas J +2 more
core +2 more sources
Advanced Science, EarlyView.L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang +6 more
wiley +1 more source
Frontiers in Genetics, 2022 Background: The study aimed to report a boy with familial exudative vitreoretinopathy and amblyopia harboring a new mutation of the LRP5 and OPA1 gene abnormality.Case presentation: A 9-year-old boy presented with a 2-year history of deteriorating visual
Chunli Chen +8 more
doaj +1 more source
How accurate is your sclerostin measurement?:Comparison between three commercially available sclerostin ELISA kits [PDF]
, 2016 Sclerostin, bone formation antagonist is in the spotlight as a potential biomarker for diseases presenting with associated bone disorders such as chronic kidney disease (CDK-MBD). Accurate measurement of sclerostin is therefore important.
Fisher, Emily +6 more
core +1 more source
Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos
Advanced Science, EarlyView.This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang +28 more
wiley +1 more source