Results 71 to 80 of about 21,385 (242)
Severe Osteoporosis With Pathogenic LRP5 Variant
JCEM Case ReportsAbstract A 24-year-old female patient was diagnosed with osteoporosis after presenting with numerous fractures throughout her childhood and adolescence. Risk factors included chronic constipation, severe vitamin D deficiency, and long-term high-dose steroid use for severe eczema.
Felicity Stringer +3 more
openaire +3 more sources
Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]
, 2016 Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja +2 more
core +2 more sources
Exploration, EarlyView.Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li +15 more
wiley +1 more source
Mir-23A-3P Regulates Osteogenesis Via Lrp5 In Hpdlscs
International Dental JournalAim or purpose: This study investigates the regulatory role of miR-23a-3p in the osteogenic differentiation of human periodontal ligament stem cells (HPDLSCs) by targeting LRP5, using lentivirus-mediated inhibition/overexpression models.
Zhang Honghong, Kang Na
doaj +1 more source
Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts. [PDF]
PLoS ONE, 2017 Wnt3a is a major regulator of bone metabolism however, very few of its target genes are known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and co-receptors Lrp5/6 to activate the canonical signaling pathway.
Aimy Sebastian +5 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: The study aimed to report a boy with familial exudative vitreoretinopathy and amblyopia harboring a new mutation of the LRP5 and OPA1 gene abnormality.Case presentation: A 9-year-old boy presented with a 2-year history of deteriorating visual
Chunli Chen +8 more
doaj +1 more source
Journal of Periodontology, EarlyView.Abstract Background Recent advancements in bone tissue biomarker research have identified 2 promising molecules: Dickkopf‐1 and secreted Frizzled‐Related Protein 5. This study aims to evaluate the levels of these biomarkers in gingival crevicular fluid in periodontal health, gingivitis, and periodontitis and to assess the effects of non‐surgical ...
Sukran Acipinar, Kubilay Baris
wiley +1 more source
Cholesterol modulates LRP5 expression in the vessel wall
Atherosclerosis, 2014 Macrophages are key players in atherosclerotic lesion formation and progression. We have recently demonstrated that lipid-loaded macrophages show activation of the canonical Wnt signaling pathway.To test the in vivo role of the canonical Wnt pathway in atherosclerosis we used mice deficient in the Wnt signaling receptor LRP5 (LRP5(-/-)) fed a ...
Borrell-Pages, M, Romero, JC, Badimon, L
openaire +3 more sources
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. [PDF]
PLoS ONE, 2009 Canonical Wnt signals are transduced through a Frizzled receptor and either the LRP5 or LRP6 co-receptor; such signals play central roles during development and in disease.
Charlotta Lindvall +6 more
doaj +1 more source
Axial length, myopia progression, and myopic maculopathy in Stickler syndrome
Acta Ophthalmologica, EarlyView.Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen +4 more
wiley +1 more source