Results 81 to 90 of about 21,385 (242)
Osteoporosis-Pseudoglioma in a Mauritanian Child due to a Novel Mutation in LRP5
Case Reports in Genetics, 2016 Osteoporosis-pseudoglioma (OPPG) syndrome is a very rare autosomal recessive disorder, caused by mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene.
Noura Biha +3 more
doaj +1 more source
PLoS ONE, 2017 Wnt signaling pathways are essential for bone formation. Previous studies showed that Wnt signaling pathways were regulated by miR-375. Thus, we aim to explore whether miR-375 could affect osteogenesis.
Tianhao Sun +7 more
doaj +1 more source
Journal of Fish Biology, EarlyView.Abstract Wnt proteins are a family of molecules that help control how cells grow, develop and communicate – processes that are fundamental to the development and health of all animals. Although Wnt pathways have been studied extensively in model species, very little is known about how they operate in marine fish.
Angeliki Maravelia +4 more
wiley +1 more source
Inflammation and mechanical force‐induced bone remodeling
Periodontology 2000, EarlyView.Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
A frizzled quest to dissect the molecular pharmacology of WNT signaling : from biology to signaling mechanism(s) [PDF]
, 2017 The wingless/int1 (WNT)/Frizzled (FZD) family of signal transduction pathways is highly conserved across species and controls essential physiological functions important for embryonic development, stem cell renewal, proliferation, differentiation, and ...
Arthofer, Elisa
core +1 more source
Genetic detection of two novel LRP5 mutations in patients with familial exudative vitreoretinopathy [PDF]
, 2023 Jiayu Li +12 more
openalex +1 more source
Experimental Physiology, EarlyView.Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu +4 more
wiley +1 more source
Cell-type specific potent Wnt signaling blockade by bispecific antibody. [PDF]
, 2018 Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for therapeutic development.
Bidlingmaier, Scott +6 more
core +2 more sources
PTH Stimulates Bone Formation in Mice Deficient in Lrp5 [PDF]
Journal of Bone and Mineral Research, 2007 Abstract Lrp5 deficiency decreases bone formation and results in low bone mass. This study evaluated the bone anabolic response to intermittent PTH treatment in Lrp5-deficient mice. Our results indicate that Lrp5 is not essential for the stimulatory effect of PTH on cancellous and cortical bone formation ...
Urszula T, Iwaniec +6 more
openaire +2 more sources
Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice. [PDF]
PLoS ONE, 2014 The canonical Wnt/β-catenin pathway plays a key role in the regulation of bone remodeling in mice and humans. Two transmembrane proteins that are involved in decreasing the activity of this pathway by binding to extracellular antagonists, such as ...
Astrid Liedert +9 more
doaj +1 more source