Results 91 to 100 of about 131,427 (295)

Arimoclomol in infants with Niemann-Pick disease type C: Results from the phase 2/3 open-label pediatric substudy

Molecular Genetics and Metabolism Reports
Background: Arimoclomol has been approved in the US for the treatment of Niemann-Pick disease type C (NPC) in patients aged ≥2 years, in combination with miglustat.
Eugen Mengel, Laila Arash-Kaps, Stephanie Grunewald, Sabine Weller Grønborg, Natalie Berger, Hadeel Shammas, Christine í Dali   +6 more
doaj   +1 more source

Prevalence of lumpy skin disease and associated risk factors in beef cattle in Rembang Regency, Central Java, Indonesia [PDF]

Veterinary World
Background and Aim: Lumpy skin disease (LSD) is an economically devastating infectious disease in cattle. Rembang Regency, located in Central Java, Indonesia, has suffered over 3800 cases of LSD and 75 deaths since early 2023.
Yayan Taufiq Hidayat, Roza Azizah Primatika, Yatri Drastini   +2 more
doaj   +1 more source

LSD auf dem Land. Produktion und kollektive Wirkung psychotroper Stoffe

, 2020
Forschungen mit psychedelischen Stoffen erleben derzeit eine Renaissance. Jahrzehntelang als Protestdroge der Beatniks und Hippies verpönt, werden LSD und Psilocybin erneut als Hoffnungsträger der Medizin gehandelt.
Bächi, Beat
core  

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source

Development and validation of an LC-MS/MS method to quantify lysergic acid diethylamide (LSD), iso-LSD, 2-oxo-3-hydroxy-LSD, and nor-LSD and identify novel metabolites in plasma samples in a controlled clinical trial [PDF]

, 2017
Lysergic acid diethylamide (LSD) is a widely used recreational drug. The aim of this study was to develop and validate a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantification of LSD, iso-LSD, 2-oxo-3-hydroxy LSD (O-H-LSD)
Katharina M. Rentsch, Dolder, Patrick C., Matthias E. Liechti, Liechti, Matthias E., Rentsch, Katharina M., Patrick C. Dolder   +5 more
core   +1 more source

Ni2‐Imido Bispincer Platforms: Cooperative Reactivity Enabled Through Substrate Addition Across a Ni2N Unit

Chemistry – A European Journal, EarlyView.
Ni2 bispincer complexes with an embedded central imido anchor are presented. The bispincer complexes leverage the high basicity of imido ligands to facilitate 1,2 addition of weak B─H and Si─H bonds, resulting in hydrido–amido complexes and resultingly a contortion of a Ni─Ni sigma bond to form an S = 1 species. The 1,2 addition is proposed to serve as
David de los Santos, Kritika Gour, Manar M. Shoshani   +2 more
wiley   +1 more source

Gaucher disease type 3 from infancy through adulthood: a conceptual model of signs, symptoms, and impacts associated with ataxia and cognitive impairment

Orphanet Journal of Rare Diseases
Background Gaucher disease type 3 (GD3) is a lysosomal storage disease characterized by diverse neurological and systemic manifestations. Symptoms of ataxia, cognitive impairment, and other systemic symptoms profoundly impact daily activities and the ...
Raphael Schiffmann, James Turnbull, Robert Krupnick, Ruth Pulikottil-Jacob, Chad Gwaltney, Alaa Hamed, Isabela Batsu, Walter Heine, Eugen Mengel   +8 more
doaj   +1 more source

A Framework for Supplier Management Based on Environmental, Social, and Governance Criteria for Small and Medium‐Sized Enterprises

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Corporate sustainability, grounded in environmental, social, and governance (ESG) dimensions, has become a strategic imperative for firms seeking competitiveness and resilience. In supply chain management, supplier selection is a key mechanism for translating ESG principles into practice.
Steicy de Souza Jorge Laber, Erica Luisa Correa, Alvaro Luiz Neuenfeldt Júnior, Osiris Canciglieri Junior, Jones Luís Schaefer   +4 more
wiley   +1 more source