Results 61 to 70 of about 90,690 (297)

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

The Very Long Chain Fatty Acid (C26:25OH) Linked to the Lipid A Is Important for the Fitness of the Photosynthetic Bradyrhizobium Strain ORS278 and the Establishment of a Successful Symbiosis with Aeschynomene Legumes

Frontiers in Microbiology, 2017
In rhizobium strains, the lipid A is modified by the addition of a very long-chain fatty acid (VLCFA) shown to play an important role in rigidification of the outer membrane, thereby facilitating their dual life cycle, outside and inside the plant.
Nicolas Busset, Flaviana Di Lorenzo, Angelo Palmigiano, Luisa Sturiale, Frederic Gressent, Joël Fardoux, Djamel Gully, Clémence Chaintreuil, Antonio Molinaro, Alba Silipo, Eric Giraud   +10 more
doaj   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Contrasting patterns of Asaia association with Plasmodium falciparum between field-collected Anopheles gambiae and Anopheles coluzzii from Cameroon

Microbiology Spectrum
The widespread prevalence of Asaia in mosquitoes makes it a potential candidate for paratrangenic control in Anopheles. To better understand whether this bacterium could be used for malaria control, we quantified Asaia in An.
Claudine Grâce Tatsinkou Maffo, Maurice Marcel Sandeu, Micareme Tchoupo, Fleuriane Metissa Dondji Kamga, Leon M. J. Mugenzi, Flobert Njiokou, Grant L. Hughes, Charles S. Wondji   +7 more
doaj   +1 more source

Yield of household contact investigation of patients with pulmonary tuberculosis in southern Ethiopia

BMC Public Health, 2020
Background Household Contacts (HHCs) of patients with pulmonary tuberculosis (PTB) have a higher risk of developing TB. Contact investigation is recommended to reach this group and identify undiagnosed cases.
Mubarek A. Yassin, Kesetebirhan D. Yirdaw, Daniel G. Datiko, Luis E. Cuevas, Mohammed A. Yassin   +4 more
doaj   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

3D‐Printed Ion‐Conductive Hydrogels with Tunable Mechanical–Electrical Properties for Multimodal Sign Language Recognition

Advanced Science, EarlyView.
This work successfully fabricated ion‐conductive hydrogels with low hysteresis and high conductivity using 3D printing technology. By adjusting the component ratios, the properties of the hydrogels can be tuned to meet diverse sensing requirements. Finally, a multimodal sensing sign language recognition system was constructed based on this hydrogel ...
Quan Hu, Longya Xiao, Peiqi Zhang, Qiurui Zhang, Guangsen Liu, Xinglin Qin, Zhuhui Yin, Xian Li, Yuling Wang, Hongjie Jiang   +9 more
wiley   +1 more source

LSTM with working memory

2017 International Joint Conference on Neural Networks (IJCNN), 2017
Previous RNN architectures have largely been superseded by LSTM, or "Long Short-Term Memory". Since its introduction, there have been many variations on this simple design. However, it is still widely used and we are not aware of a gated-RNN architecture that outperforms LSTM in a broad sense while still being as simple and efficient.
Pulver, Andrew, Lyu, Siwei
openaire   +2 more sources

MicrobeDiscover: A Knowledge Graph–Enabled AI Framework for Identifying Microbes for Inorganic Nanomaterial Biosynthesis

Advanced Science, EarlyView.
Microbial synthesis of nanomaterials (NMs) is eco‐friendly, but the screening of microorganisms is limited by inefficient traditional methods (currently only involving∽400 microorganisms/90 NMs). We propose AI framework MicrobeDiscover, integrating a knowledge graph of microbe‐NM interactions.
Ludi Wang, Hexing Han, Yufeng Liu, Zhiyuan Ning, Yujie Ma, Haidan Wang, Jinling Xu, Qiansheng Huang, Wenjuan Cui, Yuanchun Zhou, Yang Gao, Bin Wang, Yi Du   +12 more
wiley   +1 more source

Use of menstrual cups among school girls: longitudinal observations nested in a randomised controlled feasibility study in rural western Kenya

Reproductive Health, 2018
Background A menstrual cup can be a good solution for menstrual hygiene management in economically challenged settings. As part of a pilot study we assessed uptake and maintenance of cup use among young school girls in Kenya. Methods A total of 192 girls
Anna Maria van Eijk, Kayla F. Laserson, Elizabeth Nyothach, Kelvin Oruko, Jackton Omoto, Linda Mason, Kelly Alexander, Clifford Oduor, Aisha Mohammed, Alie Eleveld, Isaac Ngere, David Obor, John Vulule, Penelope A. Phillips-Howard   +13 more
doaj   +1 more source