Results 221 to 230 of about 16,211 (241)
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Mining LTR-retrotransposon genes for mRNA delivery
Trends in Pharmacological Sciences, 2022RNA-based therapeutics commonly use exogenous components to shuttle their cargo, leading to nonselectivity or immunogenicity. Segel et al. have elucidated an endogenous modular retroviral-like delivery system capable of encapsulating mRNA, which elicits effective transport inside cells, priming the development of endogenous vectors for gene delivery ...
Marco Herrera-Barrera, Gaurav Sahay
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Non-LTR retrotransposons in fungi
Functional & Integrative Genomics, 2008Non-long terminal repeat (non-LTR) retrotransposons have contributed to shaping the structure and function of genomes. Fungi have small genomes, usually with limited amounts of repetitive DNA. In silico approach has been used to survey the non-LTR elements in 57 fungal genomes.
Olga, Novikova +2 more
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LTR retrotransposons in plants
Russian Journal of Genetics: Applied Research, 2011Ty1/copia and Ty3/gypsy LTR retrotransposons represent a significant part of plant genomes and play an important role in their structure, functioning, and evolution. The majority of information about this group of transposable elements is related to agricultural plant species and model objects, such as Arabidopsis thaliana. The most investigated groups
I. D. Sormacheva, A. G. Blinov
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InpactorDB: A Plant LTR Retrotransposon Reference Library
2023LTR retrotransposons (LTR-RT) are major components of plant genomes. These transposable elements participate in the structure and evolution of genes and genomes through their mobility and their copy number amplification. For example, they are commonly used as evolutionary markers in genetic, genomic, and cytogenetic approaches.
Simon, Orozco-Arias +4 more
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LTR-retrotransposons in plants: Engines of evolution
Gene, 2017LTR retrotransposons are the most abundant group of transposable elements (TEs) in plants. These elements can fall inside or close to genes, and therefore influence their expression and evolution. This review aims to examine how LTR retrotransposons, especially Ty1-copia elements, mediate gene regulation and evolution.
Leonardo Galindo-González +3 more
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Reverse transcription of retroviruses and LTR retrotransposons
Cellular and Molecular Life Sciences, 2001Retroelements are mobile genetic entities that replicate via reverse transcription of a template RNA. A key component to the life cycle of these elements is the enzyme reverse transcriptase (RT), which copies the single-stranded genomic RNA of the element into a linear double-stranded DNA that is ultimately integrated into the host genome by the ...
M, Wilhelm, F X, Wilhelm
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LTR Retrotransposon-Gene Associations in Drosophila melanogaster
Journal of Molecular Evolution, 2006Thirty-three percent (228/682) of all long terminal repeat (LTR) retrotransposon sequences (LRSs) present in the sequenced Drosophila melanogaster genome were found to be located in or within 1000 bp of a gene. Recently inserted LTR retrotransposons are significantly more likely to be located in or within genes than are older, fragmented LTR ...
Eric W, Ganko +4 more
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LTR retrotransposons and the evolution of eukaryotic enhancers
Genetica, 1997Since LTR retrotransposons and retroviruses are especially prone to regional duplications and recombination events, these viral-like systems may be especially conducive to the evolution of closely spaced combinatorial regulatory motifs. Using the Drosophila copia LTR retrotransposon as a model, we show that a regulatory region contained within the ...
J F, McDonald +5 more
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Easel, a gypsy LTR-retrotransposon in the Salmonidae
Molecular and General Genetics MGG, 1995Despite the close similarities between retroviruses and the gypsy/Ty3 group of LTR-retrotransposons their host ranges are largely distinct: the retroviruses are found only in vertebrates, whereas the gypsy LTR-retrotransposons are almost exclusively restricted to invertebrates, plants and fungi.
M, Tristem +4 more
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PIGY, a new plant envelope-class LTR retrotransposon
Molecular Genetics and Genomics, 2005Plant LTR retrotransposons of the envelope class define a new branch in the Metaviridae family. They differ from other LTR retrotransposons mainly by the presence of an additional ORF downstream of the gag-pol region which has been hypothesized to be equivalent to the envelope gene of retroviruses.
Pavel, Neumann +3 more
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