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Mining LTR-retrotransposon genes for mRNA delivery
Trends in Pharmacological Sciences, 2022RNA-based therapeutics commonly use exogenous components to shuttle their cargo, leading to nonselectivity or immunogenicity. Segel et al. have elucidated an endogenous modular retroviral-like delivery system capable of encapsulating mRNA, which elicits effective transport inside cells, priming the development of endogenous vectors for gene delivery ...
Marco Herrera-Barrera, Gaurav Sahay
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Easel, a gypsy LTR-retrotransposon in the Salmonidae
Molecular and General Genetics MGG, 1995Despite the close similarities between retroviruses and the gypsy/Ty3 group of LTR-retrotransposons their host ranges are largely distinct: the retroviruses are found only in vertebrates, whereas the gypsy LTR-retrotransposons are almost exclusively restricted to invertebrates, plants and fungi.
M, Tristem +4 more
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Reverse transcription of retroviruses and LTR retrotransposons
Cellular and Molecular Life Sciences, 2001Retroelements are mobile genetic entities that replicate via reverse transcription of a template RNA. A key component to the life cycle of these elements is the enzyme reverse transcriptase (RT), which copies the single-stranded genomic RNA of the element into a linear double-stranded DNA that is ultimately integrated into the host genome by the ...
M, Wilhelm, F X, Wilhelm
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InpactorDB: A Plant LTR Retrotransposon Reference Library
2023LTR retrotransposons (LTR-RT) are major components of plant genomes. These transposable elements participate in the structure and evolution of genes and genomes through their mobility and their copy number amplification. For example, they are commonly used as evolutionary markers in genetic, genomic, and cytogenetic approaches.
Simon, Orozco-Arias +4 more
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The Application of LTR Retrotransposons as Molecular Markers in Plants
2012Retrotransposons are a major agent of genome evolution. Various molecular marker systems have been developed that exploit the ubiquitous nature of these genetic elements and their property of stable integration into dispersed chromosomal loci that are polymorphic within species.
Schulman, Alan H +3 more
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LTR Retrotransposon-Gene Associations in Drosophila melanogaster
Journal of Molecular Evolution, 2006Thirty-three percent (228/682) of all long terminal repeat (LTR) retrotransposon sequences (LRSs) present in the sequenced Drosophila melanogaster genome were found to be located in or within 1000 bp of a gene. Recently inserted LTR retrotransposons are significantly more likely to be located in or within genes than are older, fragmented LTR ...
Eric W, Ganko +4 more
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Horizontal transfer of non-LTR retrotransposons in vertebrates
Genetica, 1999Since their discovery in family Bovidae (bovids), Bov-B LINEs, believed to be order-specific SINEs, have been found in all ruminants and recently also in Viperidae snakes. The distribution and the evolutionary relationships of Bov-B LINEs provide an indication of their origin and evolutionary dynamics in different species.
D, Kordis, F, Gubensek
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Vertebrate LTR Retrotransposons of the Tf1/Sushi Group
Journal of Molecular Evolution, 2001LTR retrotransposons of the Tf1/sushi group from a diversity of vertebrates, including fish, amphibians, and mammals (humans, mice, and others), are described as full-length or partial elements. These elements are compared, and the mechanisms involved in self-priming of reverse transcriptase and programmed phase shifting are inferred.
M, Butler +4 more
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PucciDB: A LTR-retrotransposon library of Pucciniales
2021Les rouilles sont des champignons qui infectent les plantes, et en particulier certaines cultures importantes telles que le blé et le café. Il existe plusieurs génomes de la rouille séquencés et libérés dans des bases de données comme NCBI, mais il n'y a pas d'études approfondies sur la dynamique et les structures des éléments transposables et des ...
Simón Orozco-Arias +5 more
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The Application of LTR Retrotransposons as Molecular Markers in Plants
2004Retrotransposons are major, dispersed components of most eukaryotic genomes. They replicate by a cycle of transcription, reverse transcription, and integration of new copies, without excising from the genome in the process. Because they represent a major share of the genome, cause easily detectable genetic changes having known ancestral and derived ...
Alan H, Schulman +2 more
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