Results 151 to 160 of about 331,888 (266)

A protocol for tracking scholarly output to evaluate the impact of the RADx-UP program on community-engaged COVID-19 research. [PDF]

J Clin Transl Sci
Lucas VA, Kuhn ML, Witkemper KD, Carr T, Snipes AO, Hayes BE, Song M, Frerichs L, Dave G.   +8 more
europepmc   +1 more source

The United States Leads the Globe in Venture Capital Funding for Orthopaedic Surgery

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To characterize venture capital (VC) investments in orthopaedic surgery over the past 25 years to evaluate trends in global innovation. Methods All VC investments related to orthopaedic surgery between January 2000 and December 2024 were retrospectively evaluated using the PitchBook database (PitchBook Platform, PitchBook Data.
Mathangi Sridharan, Charlotte F. Wahle, Paul Walker, Luke Barry, Jonathan Yu, Frank Petrigliano, Lauren Wessel, Andrew R. Jensen   +7 more
wiley   +1 more source

Improving an Interprofessional Shared Mental Model and Mutual Understanding Within the Early Links of the Chain of Survival. [PDF]

Cureus
Grant C, Iturrrey C, Batista K, Yassa M, Alorda A, Gue S, Walker A.   +6 more
europepmc   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Ischemic stroke triggers brain-wide synaptic remodeling within four hours. [PDF]

PLoS Biol
Chen H, Wei Y, Ruje L, Du F, Feng Z, Wan Q, Spivakov M, Glebov OO.   +7 more
europepmc   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Caring Across Generations: The Urgent Need to Support Young Carers in Canada's Aging Population. [PDF]

Can Geriatr J
Perri LX, Fakolade A, Okrainec K, Lewin W.   +3 more
europepmc   +1 more source

Nerve growth factor is sufficient to cause multiple osteoarthritis‐relevant pathological features in naïve murine knee joints

Arthritis &Rheumatology, Accepted Article.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped due to side‐effects in the joints. Knowledge about the biological effects of NGF on joint tissues is limited.
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Two Novel Trichoderma Species and their Antagonistic Activity against Sclerotia-producing Plant Pathogens. [PDF]

Curr Microbiol
Rembinski J, Sales LS, Marbach PAS, De Souza JT.   +3 more
europepmc   +1 more source

Single‐Stage Repair of Complex Anterolateral Radial and Posterior Root Tears of the Lateral Meniscus, With a Concomitant Multiligament Knee Reconstruction of the Anterior Cruciate Ligament, Medial Collateral Ligament, Posterior Oblique Ligament, and Anterolateral Ligament in a Young Athlete

Arthroscopy Techniques, EarlyView.
Abstract Early meniscal repair and anatomic reconstruction in a multiligament knee injury optimizes outcomes and restores tibiofemoral mechanics. This technique describes a lateral meniscus posterior root and radial tear repair, with concomitant medial ramp repair, performed during single‐stage reconstruction of the anterior cruciate ligament ...
Romir Patel, Sarah L. Larson, Benjiman J. Wilebski, Luke V. Tollefson, Matthew T. Rasmussen, Dustin R. Lee, Robert F. LaPrade   +6 more
wiley   +1 more source