Results 161 to 170 of about 331,888 (266)

Absent the pre-B cell receptor checkpoint, the B-1a immunoglobulin CDR-H3 repertoire normalizes by convergent selection. [PDF]

Front Immunol
Vaz LTC, Blackburn T, Elgavish A, Vale AM, Burrows PD, Schroeder HW, Khass M.   +6 more
europepmc   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Population genomics of <i>Anopheles darlingi</i>, the principal South American malaria vector mosquito. [PDF]

Science
Tennessen JA, Brosula R, Chabanol E, Bickersmith S, Early AM, Laws M, Kelley KA, Grillet ME, Gamboa D, Lucas ER, Duchemin JB, Quiñones ML, Sallum MAM, Bergo ES, Moreno JE, Nagi S, Arisco NJ, Sooklall M, Niles-Robin R, Castro MC, Cox H, Gendrin M, Conn JE, Neafsey DE.   +23 more
europepmc   +1 more source

Completion vs. early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Chemotherapy is given for early‐stage breast cancer; however, some patients discontinue before completing all planned cycles. This study investigated the impact of early chemotherapy discontinuation on treatment outcomes. Methods This retrospective cohort study used a target trial emulation framework to conduct a causal analysis of the all‐
Luke Steventon, Chengsheng Ju, Kenneth K. C. Man, Rebecca Roylance, Diego Ottaviani, Chiara Creed, Michal Sladkowski, Alec Wisner, Li Wei, Pinkie Chambers   +9 more
wiley   +1 more source

Symptom Profiles and Anatomical Distribution of Deep Infiltrating Endometriosis. [PDF]

Cureus
Jammula V, Lee L, Huynh J, Zhu M, Spring-Robinson C, Schultzel M, Koshy-Chenthittayil S.   +6 more
europepmc   +1 more source

A pipeline crisis or a sustainability crisis? Local and national succession planning for headteachers in England

British Educational Research Journal, EarlyView.
Abstract Recruiting and retaining school leaders is a challenge in many systems worldwide. Previous research has identified three distinct ways in which succession planning can be conceptualised and approached: a ‘pipeline’ approach seeks to match supply and demand for the posts that need filling; a ‘pool’ strategy involves proactively identifying and ...
Toby Greany, Pat Thomson, Tom Perry, Mike Collins   +3 more
wiley   +1 more source

Underestimation of Cardiovascular Risk by 2019 World Health Organization (WHO) Cardiovascular Risk Charts Compared With Framingham Global Risk Score (FGRS) in a Brazilian Population: Implications for Primary Prevention. [PDF]

Cureus
Teixeira da Matta Flora Neto A, Petraglia Barroso L, Rodrigues Fernandes L, O'Connell JL.   +3 more
europepmc   +1 more source

‘Fish in simulated water’? A Bourdieusian analysis of Chinese doctoral students' learning experiences in Southeast Asian developing countries

British Educational Research Journal, EarlyView.
Abstract International student mobility (ISM) has historically followed a pattern of movement from developing regions to developed countries. However, in recent years, there has been a noticeable increase in the number of Chinese students pursuing doctoral studies in Southeast Asian developing countries, an area that has received relatively little ...
Yueyang Zheng, Kun Dai, Alan C. K. Cheung   +2 more
wiley   +1 more source

Unraveling the nexus: Tumor mutational burden, PD-L1 expression, and oncogenic alterations in non-small cell lung cancer cytology specimens. [PDF]

Cancer Cytopathol
Dai M, San Lucas FA, Alvarez H, Ballester L, Chen H, Patel KP, Rashid A, Rao S, Routbort MJ, Sura G, Sweeney K, Toruner G, Wei P, Yang R, Dang H, Luthra R, Roy-Chowdhuri S.   +16 more
europepmc   +1 more source

Form flows function: Learner‐centered game Re‐design in a STEM classroom

British Educational Research Journal, EarlyView.
Abstract Re‐designing games facilitates interest‐driven learning and immerses learners in systems thinking. However, there are limited studies exploring how the form and function of tabletop games influence learners' design decisions and learning experiences. To address this gap, we conducted a mixed‐methods study in a STEM classroom in western Canada.
Farzan Baradaran Rahimi, Beaumie Kim, Shima Dadkhahfard   +2 more
wiley   +1 more source