Results 231 to 240 of about 67,421 (349)

An advanced multimodal image fusion model for accurate detection of Alzheimer's disease using MRI and PET. [PDF]

Front Med Technol
Ansari AS, Mohammadi MS, Cattani C, Tassaddiq A.   +3 more
europepmc   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, EarlyView.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

New insights for an old drug: difluoromethylornithine boosts the trypanocidal action of benznidazole on <i>Trypanosoma cruzi in vitro</i> and <i>in vivo</i>. [PDF]

Front Cell Infect Microbiol
Martínez SJ, Vanrell MC, Li X, Carrillo C, Engman DM, Romano PS.   +5 more
europepmc   +1 more source

Orfelia-type luciferin and its associated storage protein in the non-luminescent cave worm Neoditomyia sp. (Diptera: Keroplatidae) from the Atlantic rainforest: biological and evolutionary implications

Photochemical and Photobiological Sciences, 2018
V. Viviani, D. Amaral, V. R. Bevilaqua, R. Falaschi   +3 more
semanticscholar   +1 more source

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

<i>Chaetopterus</i> Luciferase: A Promising Tool for Online Lipid Peroxidation Detection. [PDF]

Int J Mol Sci
Shcheglov AS, Purtov KV, Zagitova RI, Kozhemyako VB, Tsarkova AS, Pepoyan A, Yampolsky IV.   +6 more
europepmc   +1 more source

Phosphate starvation induces root cell‐type‐specific transcriptional responses and alternative splicing

New Phytologist, Volume 250, Issue 5, Page 3212-3229, June 2026.
Summary Phosphate (Pi) is an essential nutrient for plant growth, and understanding how Arabidopsis thaliana root cells respond to Pi deficiency is crucial to decipher whole plant responses. We perform high‐resolution transcriptomic profiling across five distinct root cell types, identifying differentially expressed genes (DEGs) and differential ...
Mary‐Paz González‐García, Mónica Lanza, Victoria Baca‐González, Estefano Bustillo‐Avendaño, Laura Serrano‐Ron, Sara González‐Bodi, Jose M. García‐Mina, Ángel M. Zamarreño, María Garnica, Miguel A. Moreno‐Risueno, Elena Caro, Juan C. del Pozo   +11 more
wiley   +1 more source

Longitudinal Analysis of Male Fertility Using an Acr-Luc Knock-In Mouse Model: A Preclinical Platform for Reproductive Toxicity Testing. [PDF]

MedComm (2020)
Fukunaga H, Seino R, Matsuya Y, Takashima H, Ishikawa M, Onodera Y, Shirato H, Miyata H, Prise KM.   +8 more
europepmc   +1 more source

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, Volume 38, Issue 26, 8 May 2026.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source