Results 41 to 50 of about 64,206 (131)

Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis

JOR SPINE, Volume 8, Issue 4, December 2025.
Mouse models are commonly used to study IVD degeneration and related neurological conditions that especially impact elder population. However, how well mice replicate human pathology remains unclear. This study compared lumbar IVD degeneration patterns across age and spinal levels in humans and mice.
Ravij Mehta, Sarthak Mohanty, Andrew Parker Hallmark, Veeraj Shah, Tom Ross, Eric A. Bogner, Tejbir S. Pannu, Mathieu Bannwarth, Sohrab Virk, Sravisht Iyer, James C. Farmer, Russel C. Huang, Darren R. Lebl, Bernard A. Rawlins, Harvinder S. Sandhu, Han Jo Kim, Matthew E. Cunningham, Sheeraz Qureshi, Todd J. Albert, Chitra L. Dahia   +19 more
wiley   +1 more source

Recurrent Lumbar Disc Herniation: A Review

Global Spine Journal, 2017
Study Design: Narrative review. Objectives: To identify the risk factors and surgical management for recurrent lumbar disc herniation using a systematic review of available evidence.
Nicholas Shepard, Woojin Cho
semanticscholar   +1 more source

Injury Induces More Severe Biomechanical Changes in Middle‐Aged and Geriatric Lumbar Spines in a Mouse Ex Vivo Model

JOR SPINE, Volume 8, Issue 4, December 2025.
Injury and age exhibited an interactive effect, resulting in greater biomechanical dysfunction in middle‐aged (12 months) and geriatric (24 months) mouse intervertebral discs (IVDs), associated with age‐related proteoglycan loss and collagen denaturation as shown by FTIR and histological analyses.
Neharika Bhadouria, Justin Tiao, Angelica Baburova, Charu Jain, Bowen Wang, Antonia Demopoulos, Philip Nasser, Andrew P. Hallmark, Veeraj Shah, Jennifer R. Weiser, Deepak Vashishth, Chitra L. Dahia, Yunsoo Lee, Andrew C. Hecht, James C. Iatridis   +14 more
wiley   +1 more source

The Impact of the Ovine Annular Lesion Model on IVD Pathobiology and Utility of the Ovine Spinal Model in Patho‐Anatomical Studies: A Historical Perspective

JOR SPINE, Volume 8, Issue 4, December 2025.
The ovine annular rim‐lesion model of intervertebral disc degeneration of Osti and colleagues (1990) has evolved into a sophisticated mechanical destabilization large animal model of intervertebral disc degeneration over its 35 year history offering diverse musculoskeletal multi‐disciplinary investigations into the multifunctional complexity of this ...
O. Osti, C. B. Little, J. Melrose
wiley   +1 more source

Risk Factors for Recurrent Lumbar Disc Herniation

Medicine, 2016
Recurrent lumbar disc herniation (rLDH) is a common complication following primary discectomy. This systematic review aimed to investigate the current evidence on risk factors for rLDH.Cohort or case-control studies addressing risk factors for rLDH were ...
Weimin Huang, Zhiwei Han, Jiang Liu, Lili Yu, Xiu-chun Yu   +4 more
semanticscholar   +1 more source

Advancing Intervertebral Disc Biology via Omics: Implications for Nucleus Pulposus Progenitor Cell‐Based Regeneration

JOR SPINE, Volume 8, Issue 4, December 2025.
Intervertebral disc degeneration (IDD) is a multifactorial condition underpinned by complex molecular mechanisms. This review highlights advances in RNA sequencing and multi‐omics approaches that have elucidated gene regulatory networks, cellular heterogeneity, and progenitor cell dynamics in the nucleus pulposus.
Anja Stirnimann, Leon Schlagenhof, Benjamin Gantenbein, Fabian Ille   +3 more
wiley   +1 more source

Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment

JOR SPINE, Volume 8, Issue 4, December 2025.
Condoliase digested chondroitin sulfate locally, and did not digest the collagen fibers that form the supportive architecture of the nucleus pulposus. ABSTRACT Background Condoliase is a treatment for lumbar disc herniation. This enzyme exerts its medicinal effects by digesting chondroitin sulfate (CS), which is abundant in the nucleus pulposus ...
Ippei Watanabe, Ko Takeda, Taiichi Shirogane   +2 more
wiley   +1 more source

Lovastatin‐Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle‐Puncture Induced Degeneration Model in Rat Caudal Discs

JOR SPINE, Volume 8, Issue 4, December 2025.
Lovastatin‐loaded nanoparticles were developed and incorporated into a thermosensitive chitosan hydrogel for treating intervertebral disc degeneration, showing sustained lovastatin release and enhanced production of aggrecan and Type II collagen in human nucleus pulposus cells in vitro. Animal studies using a rat caudal disc model mimicking early stage
Chih‐Wei Chen, Yung‐Hsin Cheng, Kai‐Chiang Yang, Chuan‐Ching Huang, Ming‐Hsiao Hu, Yuan‐Hui Sun, Jaw‐Lin Wang, Shu‐Hua Yang   +7 more
wiley   +1 more source

Suprapedicular Circumferential Opening Technique of Percutaneous Endoscopic Transforaminal Lumbar Discectomy for High Grade Inferiorly Migrated Lumbar Disc Herniation

BioMed Research International, 2018
Purpose To evaluate the efficacy of suprapedicular circumferential opening technique (SCOT) of percutaneous endoscopic transforaminal lumbar discectomy (PETLD) for high grade inferiorly migrated lumbar disc herniation.
H. Kim, F. Yudoyono, Byapak Paudel, Ki Joon Kim, J. Jang, Jeong-Hoon Choi, S. Chung, J. H. Kim, I. Jang, S. Oh, J. Park, Sol Lee   +11 more
semanticscholar   +1 more source

False selection rate control in mixture models

Scandinavian Journal of Statistics, Volume 52, Issue 4, Page 2014-2060, December 2025.
Abstract The clustering task consists in partitioning elements of a sample into homogeneous groups. Most datasets contain individuals that are ambiguous and intrinsically difficult to attribute to one or another cluster. However, in practical applications, misclassifying individuals is potentially disastrous and should be avoided.
Ariane Marandon, Tabea Rebafka, Etienne Roquain, Nataliya Sokolovska   +3 more
wiley   +1 more source