Results 61 to 70 of about 24,486 (252)

Impact of Obesity on Lumbar Disc Herniation

, 2023
Background: Prevalence of obesity is increasing worldwide and obese patients constitute a major portion of the spinal surgeon s practice. The patients with lumbar disc herniation present the most in the outpatient department of neurosurgery.
Khan, Murtaza Ahmed
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Standard Single Level discectomy; Evaluation of the Risk Factors for Recurrence

Egyptian Spine Journal, 2013
Background Data: Various surgical options exist for lumbar disc herniation. In patients who do not respond to conservative treatment, open discectomy still remains a standard method and it has been reported to have diverse outcomes.
Ehab El Gamal, Ashraf Farid
doaj   +1 more source

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, EarlyView.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

A Study of Lumbar Disc Herniation and Facet Joint Asymmetry

, 2018
Purpose: To investigate the association of facet joint asymmetry with lumbar disc herniation at the lower lumbar spine.
Qi Lai, Yuan Liu, Min Dai, Runsheng Guo, Jianghao Zhu, Xin Lv, Qiang Wang, Bin Zhang   +7 more
core   +1 more source

Clinical Study of Ultrasound‐Guided Modified Percutaneous Endoscopic Interlaminar Discectomy Combined With Medical Chitosan in Lumbar 4–5 Disc Herniation Treatment

Orthopaedic Surgery, EarlyView.
Ultrasound‐guided PEID plus medical chitosan can effectively reduce postoperative pain and perioperative complications, demonstrating superior clinical efficacy. ABSTRACT Objective Percutaneous endoscopic lumbar discectomy (PELD) is a preferred minimally invasive surgery for lumbar disc herniation (LDH); however, postoperative recurrence, nerve root ...
Liying Cao, Jun Zhang, Mingjing Jiang, Binzhen Lin, Nan Zhong, Xiaofeng Yin, Yiyun Guan, Xiaochun Huang, Kaiming Chen   +8 more
wiley   +1 more source

Lumbar Disc Herniation and Treatment Guidelines - CME

, 2022
Lumbar disc herniation is a prevalent pathology of low back pain worldwide affecting up to 10% of the population and up to 5% symptomatically. There have been recent advances in the surgical management of lumbar disc herniation that allow for rapid ...
Kueny, Patrick
core  

Incidence and Management of Cerebrospinal Fluid Leakage due to Late Presentation of Dural Tears After Lumbar Surgery

Orthopaedic Surgery, EarlyView.
This article reveals a 0.3% incidence of LPDT and highlights the importance of increased clinical awareness. Furthermore, appropriate management to optimize patient recovery and minimize long‐term complications. ABSTRACT Objective To investigate the incidence and treatment of cerebrospinal fluid leakage due to late presentation of dural tears (LPDT ...
Xiaoxiong Yang, Dazhao Tie, Rui Chen, Xin Chen, Yanbin Zhao, Hua Zhou, Yan Li, Lei Dang, Chuiguo Sun, Feifei Zhou   +9 more
wiley   +1 more source