Results 61 to 70 of about 20,364 (197)

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

Fetal Pathogenesis of Scoliosis Suggested by Asymmetry of Gene Expression in Paravertebral Muscles

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The dysfunction of paravertebral muscles may contribute to the development of idiopathic scoliosis. Several candidate genes have been linked to scoliosis, but the underlying mechanisms and cell types remain unclear. Methods We initially included 40 idiopathic scoliosis cases and 19 controls. Muscle biopsies were obtained bilaterally
Tian Cheng, Gamze Yazgeldi Gunaydin, Elisabet Einarsdottir, Sini Ezer, Juha Kere, Shintaro Katayama, Paul Gerdhem   +6 more
wiley   +1 more source

Spontaneous Regression of Herniated Lumbar Disc with New Disc Protrusion in the Adjacent Level

Case Reports in Orthopedics, 2016
Spontaneous regression of herniated lumbar discs was reported occasionally. The mechanisms proposed for regression of disc herniation are still incomplete. This paper describes and discusses a case of spontaneous regression of herniated lumbar discs with
Tayfun Hakan, Serkan Gürcan
doaj   +1 more source

Initial experience of clinical implementation of an Online Simulation‐free CBCT‐based Adaptive Radiotherapy (OSCAR) workflow for palliative and urgent treatment indications

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Background The current standard radiotherapy treatment planning workflow typically requires several hours to days, during which patients must wait before treatment can be initiated. In certain oncological situations, however, treatment should commence as soon as possible.
Robert Schindhelm, Anne Richter, Philip Kleine, Jörg Tamihardja, Victor Lewitzki, Bülent Polat, Marcus Zimmermann, Frederick Mantel, Thomas Fischer, Sebastian Heß, Ingulf Lawrenz, Franziska Künzig, Felix Schilling, Andrea Wittig‐Sauerwein, Gary Razinskas   +14 more
wiley   +1 more source

INFLUENCE OF FACET TROPISM ON THE LOCATION OF LUMBAR DISC HERNIATION

Coluna/Columna
Objective: To correlate facet tropism with the side and location of the intervertebral disc in which the lumbar disc herniation occurred. Methods: A retrospective descriptive study that evaluated Magnetic Resonance Imaging of 255 patients with lumbar ...
RODRIGO ARNOLD TISOT, JULIANO DA SILVEIRA VIEIRA, DIEGO DA SILVA COLLARES, LEONARDO DOMINGUES STUMM, MARIANO FERABOLI FONTANA, AUGUSTO PASINI, EDUARDO CORONEL, EDUARDO SCHARNOVSKI, MAIARA AGOSTINI, MATEUS BORIN, VICTOR KASPER, VICTOR SÁNCHEZ, WALTER ISERHARD   +12 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

A Symptomatic Spinal Extradural Arachnoid Cyst with Lumbar Disc Herniation

Case Reports in Orthopedics, 2015
Spinal epidural arachnoid cyst (EAC) is a rare, usually asymptomatic condition of unknown origin, which typically involves the lower thoracic spine. We report a case of posttraumatic symptomatic EAC with lumbar disc herniation.
Yoshinori Kadono, Takamichi Yuguchi, Yu-ichiro Ohnishi, Koichi Iwatsuki, Toshiki Yoshimine   +4 more
doaj   +1 more source

Nucleus Pulposus Resorption Following a Paraspinal Hook‐Needle Intervention for Lumbar Disc Herniation: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT The paraspinal hook‐needle intervention is a minimally invasive needle‐based procedure performed under local anesthesia using a specialized hook‐shaped needle at clinically selected lumbar segments. We report the case of a 70‐year‐old woman who presented with intermittent low back pain for more than 10 years, recently aggravated and ...
Mengying Xiao, Zhengchao Cai, Hairui Zhu, Shuanglin Mou, Wensheng Zhu   +4 more
wiley   +1 more source

Effects of Adding Whole‐Body Vibration to Routine Exercise Therapy on Pain, Disability, Muscle Strength, and Endurance in Individuals With Chronic Nonspecific Neck Pain: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Objective Chronic nonspecific neck pain (CNNP) is highly prevalent, and exercise therapy is regarded as an effective intervention. Whole‐body vibration (WBV) may enhance neuromuscular activation and potentially improve muscle strength and endurance; however, evidence on its application in individuals with neck pain remains ...
Fatemeh Arghon, Hoda Niknam, Khosro Khademi Kalantari, Alireza Akbarzadeh Baghban   +3 more
wiley   +1 more source