Results 61 to 70 of about 356,501 (238)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Isolated lumbar extension exercise as an intervention for chronic low back pain [PDF]

, 2015
Low back pain (LBP) is highly prevalent, generally categorised as ‘non-specific’ as clear diagnosis for pain is often absent, and further categorised into acute, sub-acute and chronic, with 69-75% of acute cases developing into chronic.
Steele, James
core  

Factors That Influence Recurrent Lumbar Disc Herniation

, 2017
Introduction: The most common cause of poor outcome following lumbar disc surgery is recurrent herniation. Recurrence has been noted in 5% to 15% of patients with surgically treated primary lumbar disc herniation. There have been many studies designed to
Mesut E Yaman, Gıyas Ayberk, Ayberk, Giyas, Yaman, Mesut E., Yaman, Mesut Emre, YAMAN, NUR DİKMEN, Giyas, Ayberk, Baş, Ferhat, Ferhat Baş, null null, Nur D Yaman, Yaman, Nur D., Kazancı, Atilla, Atilla Kazancı, Kazanci, Atilla   +14 more
core   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Standard Single Level discectomy; Evaluation of the Risk Factors for Recurrence

Egyptian Spine Journal, 2013
Background Data: Various surgical options exist for lumbar disc herniation. In patients who do not respond to conservative treatment, open discectomy still remains a standard method and it has been reported to have diverse outcomes.
Ehab El Gamal, Ashraf Farid
doaj   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

Mini‐Open Versus Open Transforaminal Lumbar Interbody Fusion in Patients Aged ≥ 75 Years: Perioperative Surgical Burden and Clinical Outcomes

Orthopaedic Surgery, EarlyView.
In 172 patients aged ≥ 75 years undergoing TLIF, mini‐open TLIF (MO‐TLIF) reduced perioperative burden (shorter operative time, less blood loss, lower POD3 CK) and enabled faster early pain/function recovery versus open TLIF, while 3–6 month PROMs and 12‐month fusion and satisfaction were comparable.
Zhendong Huang, Kelv Shen, Fengxian Jiang, Fengyu Ma, Xiang Wang, Hui Wang, Zhengfeng Lu   +6 more
wiley   +1 more source

A Retrospective Comparative Study on Arthroscopic‐Assisted Uni‐Portal Spinal Surgery (AUSS/UNSES) Versus Unilateral Biportal Endoscopy for Double‐Segment Lumbar Spinal Stenosis

Orthopaedic Surgery, EarlyView.
This retrospective comparative study demonstrates that Arthroscopic‐Assisted Uni‐portal Spinal Surgery (AUSS/UNSES) for double‐segment lumbar stenosis achieves equivalent 12‐month clinical outcomes to Unilateral Biportal Endoscopy (UBE), while offering significant perioperative advantages including shorter operative time, reduced drainage and ...
Zhide Liu, En Song, Shiyuan Hao, XiangLong Li, Yabo Yao, Jianfeng Zhong   +5 more
wiley   +1 more source

Annular Repair Using an All‐Suture Anchor Under Unilateral Biportal Endoscopy: Technical Note and Case Series

Orthopaedic Surgery, EarlyView.
Procedural Steps and Schematic Illustrations of the All‐Suture Anchor–Assisted Annular Repair. (A) Exposure of the herniated intervertebral disc. (B) Residual annular defect after removal of herniated nucleus pulposus. (C) A suture‐passing hook penetrates the superior margin of the annular defect, delivering a PDS shuttle suture.
Pengzhi Shi, Jiarui Liu, Chao Li, Mingyu Gao, Sheng Chang, Xuexiao Ma, Hongfei Xiang   +6 more
wiley   +1 more source

Lumbar Disc Herniation

Romanian Neurosurgery
Lumbar disc hernia represents one of the most frequent neurosurgical pathologies, consisting of a posterior migration of the nucleus pulposus which protrudes through the surrounding protective connective tissue. The patient usually exhibits leg pain, paraesthesia or a variable degree of discomfort at the lower extremities, those clinical ...
Asdrubal Falavigna, Andre Moreira Castilho, Pedro Augusto Rocha Torres   +2 more
  +5 more sources