Results 71 to 80 of about 44,115 (283)

50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper‐buoyancy floatation versus 15 min sitting upright

Experimental Physiology, EarlyView.
Abstract Microgravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness ...
David Marcos‐Lorenzo, Christina Lysandrou, Laura Sudres, Alfonso Gil‐Martinez, Jaap Swanenburg, James Edward Clark, David Andrew Green   +6 more
wiley   +1 more source

A method for quantitative measurement of lumbar intervertebral disc structures:an intra- and inter-rater agreement and reliability study [PDF]

, 2013
BACKGROUND: There is a shortage of agreement studies relevant for measuring changes over time in lumbar intervertebral disc structures. The objectives of this study were: 1) to develop a method for measurement of intervertebral disc height, anterior and ...
Jensen, Tue Secher, Kjær, Per, Samir Chreiteh, Shadi, Tunset, Andreas   +3 more
core   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology

JOR SPINE, Volume 9, Issue 2, June 2026.
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou, Zerihun G. Workineh, Maria Segarra‐Queralt, Francis Kiptengwer Chemorion, Paola Bermudez‐Lekerika, Exarchos Kanelis, Katherine B. Crump, Benjamin Gantenbein, Leonidas G. Alexopoulos, Christine L. Le Maitre, Janet Piñero, Jérôme Noailly   +11 more
wiley   +1 more source

Development and validation of a nomogram for predicting postoperative recurrent lumbar disc herniation after unilateral biportal endoscopic discectomy

Scientific Reports
No study has investigated the incidence or risk factors of recurrent lumbar disc herniation (rLDH) after unilateral biportal endoscopic discectomy (UBED) in patients with lumbar disc herniation. Therefore, we aimed to construct and verify a nomogram that
Zhibin Xing, Hongyu Guo, Yuepeng Song, Lingli Cai, Renhao Zhang, Miaomiao Zhu   +5 more
doaj   +1 more source

Full-endoscopic lumbar discectomy for high canal compromised disc at upper lumbar level: A technical review

Indian Journal of Pain, 2018
Objective: In this study, we have described the technique to overcome difficulty faced during trans-foraminal endoscopic discectomy for the treatment of lumbar radiculopathy in patients who have herniated discs at the upper lumbar level & thoracolumbar ...
Manish Raj, Kailash Kothari, Anurag Agarwal, Hyeun Sung Kim, Pankaj Surange, Kapil Tyagi, Prashant Punia, Palea Ovideu   +7 more
doaj   +1 more source

Patients With Chronic Low Back Pain Without Advanced Disk Degeneration Exhibit Gut Microbiome Dysbiosis: Evidence From an Age‐, Sex‐, and BMI‐Matched Pilot Study

JOR SPINE, Volume 9, Issue 2, June 2026.
Chronic low back pain in patients without advanced disc degeneration is associated with gut microbiome dysbiosis, marked by reduced microbial diversity and altered bacterial composition. These findings support a gut–disk axis in which impaired gut barrier integrity and systemic inflammation may contribute to disc inflammation, nociceptive fiber ...
Stone Sima, Thomas Jeffries, Alisha Sial, Suhani Sharma, Neha Chopra, Fan Zhang, Georgina Hold, Wentian Li, Ji Tu, Victor Chen, Ashish Diwan   +10 more
wiley   +1 more source

Spontaneous Regression of Traumatic Lumbar Disc Herniation: A Case Report and Literature Review

Journal of Medical Sciences
Traumatic intervertebral disc herniation is more common in the cervical spine than in the lumbar spine. Traumatic lumbar disc herniation (LDH) had the same symptoms as degenerative LDH including low-back pain and nerve root radiculopathy.
Chia-Yuan Chang
doaj   +1 more source

Extraforaminal Intraradicular Disc Herniation. Case Report

Egyptian Spine Journal, 2012
Background data: The intraradicular penetration of a disc fragment was first reported in 1984 and is much less frequent than the intradural disc herniation.
Joerg Silbermann, Yasser Allam
doaj   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source