Results 41 to 50 of about 356,501 (238)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li   +9 more
wiley   +1 more source

Spontaneous regression of lumbar disc herniation: four cases report and review of the literature [PDF]

open access: yes
Spontaneous regression of lumbar disc herniation refers to shrinkage or disappearance of herniated nucleus pulposus without invasive surgical treatments.
Zhu, Can   +4 more
core   +1 more source

Endoscopic anatomy and features of lumbar discectomy by Destandau technique

open access: yesInterdisciplinary Neurosurgery, 2017
Minimally invasive spine surgery prevents alteration of paraspinal muscles and avoids traditional open surgery, so in the majority of cases, recovery is much quicker and patients have less back pain after surgery.
Keyvan Mostofi, Jean Destandau
doaj   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia   +8 more
wiley   +1 more source

Pattern of Spine Degenerative Disease Among Patients Referred for Lumbar Magnetic Resonance Imaging at Muhimbili National Hospital, Dar es salaam, Tanzania March-September-2010. [PDF]

open access: yes, 2011
Background Degenerative disease of the lumbar spine refers to a syndrome in which an intervertebral disk with adjacent spine structures are compromised. This causes low back and lower extremity pain.
Jacob, Mboka
core  

Surgical treatment options for lumbar disc herniation.

open access: yes, 2023
Surgical treatment options for lumbar disc herniation.
Tulyapruek Tawonsawatruk (15194813)   +7 more
core   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

open access: yesAdvanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen   +9 more
wiley   +1 more source

Computational simulation of the intervertebral disc [PDF]

open access: yes, 2013
The intervertebral disc is a complex structure unlike any other in the human body. The capability to withstand high loads and deformations in six degrees of freedom is facilitated by the unique soft tissue structures. However, the mechanical behaviour of
Luxmoore, Bethany Jane
core   +5 more sources

The Extraforaminal Approach for the Management of Far Lateral Lumbar Disc Herniation

open access: yesEgyptian Spine Journal, 2017
Background Data: Far lateral lumbar disc herniation accounts for 1-12% of all lumbar disc herniations. Every aspect of management of this unique type of lumbar disc herniation is challenging for spine surgeons, and no consensus has been reached for the ...
Al Moataz El-Sabrout   +3 more
doaj   +1 more source

A rare case of perineal neuralgia treated with ultrasound‐guided nerve block combined with water separation

open access: yesIbrain, Volume 11, Issue 1, Page 106-111, Spring 2025.
A middle‐aged man presented with a right indirect inguinal hernia in November 2020 and underwent laparoscopic high ligation of the right hernial sac. Intermittent acupuncture‐like pain in the skin of the right scrotum and medial thigh occurred 1 month after surgery and lasted for 6 months. Under ultrasound guidance, ilioinguinal nerve and genitofemoral
Yong Wang   +4 more
wiley   +1 more source

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