Results 41 to 50 of about 20,364 (197)

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Residual leg numbness after endoscopic discectomy treatment of lumbar disc herniation

BMC Musculoskeletal Disorders, 2020
Background Transforaminal endoscopic discectomy was popular in the treatment of lumbar disc herniation. Previous study focuses on the leg pain of disc herniation, and little study concern the residual leg numbness after surgery.
Denglu Yan, Zaiheng Zhang, Zhi Zhang
doaj   +1 more source

Predictive factors of epidural blood patch success in intracranial hypotension syndrome

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to identify predictors of epidural blood patch (EBP) success in patients with intracranial hypotension syndrome. Background The epidural blood patch remains the gold standard treatment for intracranial hypotension syndrome, yet its effectiveness varies, and predictors of sustained success remain uncertain. Methods We
Anna Le Moal‐Baczynski, Alexandre Castelli, Vincent Doat‐Sarfati, Sylvain Redon, Anne Donnet, Nicolas Bruder, François Antonini, Jules Henri, Jean‐François Hak, Victor Lebreton, Jeanne Morel, Mehdi Assal, Lionel Velly, Pierre Simeone   +13 more
wiley   +1 more source

Standard Single Level discectomy; Evaluation of the Risk Factors for Recurrence

Egyptian Spine Journal, 2013
Background Data: Various surgical options exist for lumbar disc herniation. In patients who do not respond to conservative treatment, open discectomy still remains a standard method and it has been reported to have diverse outcomes.
Ehab El Gamal, Ashraf Farid
doaj   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, EarlyView.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Regression of lumbar disc herniation with non-surgical treatment: a case report

Journal of International Medical Research, 2021
To date, only a few reports have described the regression of lumbar disc herniation, which may be because of a failure to follow up patients treated conservatively.
Rui Wang, Huasong Luo
doaj   +1 more source

Clinical Efficacy and Learning Curve of Far‐Lateral Approach (FLA) in Uni‐Portal Non‐Coaxial Spinal Endoscopic Surgery (UNSES) in the Treatment of Lumbar Degenerative Diseases: A Prospective Study

Orthopaedic Surgery, EarlyView.
UNSES via FLA is a safe and effective minimally invasive technique for treating complex lumbar degenerative diseases. It has a certain learning curve, and the inflection point is about the 16th case. After mastering the key techniques such as anatomical positioning, endoscopic manipulation and hemostasis, the surgeon can gradually reach the proficiency
Mengchen Yin, Wenlong Yu, Yan Lou, Jianfeng Sha, Yang Xue, Dong Zhang, Kaipeng Huang, Kai Lv, Zhichao Ge, Jianmin Li, Jiajun Wu, Hao Sun, Shuqiang Wang   +12 more
wiley   +1 more source

Suture‐Related Delayed Epidural Hematoma Following Cervical Open‐Door Laminoplasty: A Report of Two Cases and Literature Review

Orthopaedic Surgery, EarlyView.
We report two cases of delayed postoperative spinal epidural hematoma occurring on postoperative Day 7 after cervical open‐door laminoplasty. Emergency MRI showed large paraspinal intramuscular hematomas compressing the cord, and re‐exploration found loose barbed sutures with muscle bleeding.
Xiaoxuan Huang, Can Guo, Junbo He, Yi Yang, Kangkang Huang, Hao Liu, Chen Ding   +6 more
wiley   +1 more source