Results 51 to 60 of about 1,106,079 (303)

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

A retrospective study on the effects of unilateral biportal endoscopic lumbar interbody fusion on functional recovery in patients undergoing single-level lumbar interbody fusion

Translational Neuroscience
To compare the clinical outcomes of unilateral biportal endoscopic lumbar interbody fusion (ULIF) versus posterior lumbar interbody fusion (PLIF) in patients undergoing single-level L3–S1 lumbar interbody fusion.
Huang Xinyun, Ling Shi, Cao Qi
doaj   +1 more source

Rates of Fusion Procedures following Lumbar Microdiscectomy

Global Spine Journal, 2015
Introduction Ten percent of the patients with lumbar herniated disc disease end up having chronic pain and disability from herniation. Microdiscectomy has long been the standard treatment for lumbar disc herniation.
Paramjit Singh, Justin Wang, Jeremiah Cohen, Lance Smith, Zorica Buser, Jeffrey Wang   +5 more
doaj   +1 more source

Comparison between posterior lumbar interbody fusion and transforaminal lumbar interbody fusion in the management of lumbar spondylolisthesis

Bratislava Medical Journal, 2021
Lumbar spondylolisthesis is a relatively common cause of low back and lower extremity pain. The most common type, degenerative lumbar spondylolisthesis (DLS), is a disease that causes stenosis of the spinal canal. Two surgical methods of treatment are widely accepted, namely posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody ...
V, Katuch, R, Grega, K, Knorovsky, J, Banoci, J, Katuchova, M, Sasala, H, Ivankova, P, Kapralova   +7 more
openaire   +3 more sources

Endoscopic lumbar spinal hybrid surgery in the treatment of multiple-level lumbar degenerative spondylolisthesis and spinal stenosis

Interdisciplinary Neurosurgery, 2022
Background: Elderly patients frequently suffer from multi-level degenerative lumbar spondylolisthesis/stenosis, particularly heavy labor workers, farmers, and obese individuals.
Kai-Ting Chien, Pao-Sheng Peng
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Outcome of Salvage Lumbar Fusion after Lumbar Arthroplasty [PDF]

Asian Spine Journal, 2014
Study DesignRetrospective review.PurposeThis study aims to define the role of lumbar fusion for persistent back pains after the lumbar disc replacement.Overview of LiteratureLittle is written about lumbar fusion after optimally placed lumbar arthroplasty
Hussein Alahmadi, Harel Deutsch
doaj   +1 more source

Radiological and Clinical Comparison of Posterolateral Fusion and Transforaminal Interbody Fusion Techniques in Degenerative Lumbar Stenosis

, 2018
OBJECTIVE: Fusion surgery for lumbar degenerative stenosis is an established treatment mode. Despite comparable patient-related outcomes and radiologic results, the necessity of adding interbody fusion to posterolateral fusion remains controversial.
Gokhan Bozkurt, Sahin Hanalioglu, Isikay, Ilkay, Bozkurt, Gokhan, Ilkay Isikay, Hanalioglu, Sahin   +5 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Using tantalum cages in interbody fusion in osteoporotic lumbar degenerative disorders. Does it make any difference?

The Egyptian Orthopaedic Journal
Background: Lumbar interbody fusion is one of the most commonly used modality of treatment of lumbar degenerative disorders. The use of interbody cages restores lumbar lordosis and increases fusion rates.
Mahmoud Ashour, tameem elkhateeb, abdelrady abdelrady, Moustafa Kandeel   +3 more
doaj   +1 more source