Results 101 to 110 of about 461,652 (367)

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Annals of Neurology, EarlyView.
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau, Agnès Sommet, Pierre Payoux, Pierre Gantet, Amel Drif, Hélène Catalá, Claire Thalamas, Christine Tranchant, Franck Durif, Ana Marques, Alexandre Eusebio, Luc Defebvre, Jean‐Christophe Corvol, Stéphane Thobois, Anthime Flaus, Anne‐Gaelle Corbille, Solène Frismand, Beverley Patterson, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Germain Arribarat, Patrice Péran, Olivier Rascol, for the ASPIRE Study Group   +26 more
wiley   +1 more source

Systematic review of new medics’ clinical task experience by country [PDF]

, 2014
OBJECTIVES: There is a need for research which informs on the overall size and significance of clinical skills deficits among new medics, globally. There is also the need for a meta-review of the similarities and differences between countries in the ...
Dickson GD, Goodfellow PB, Moghadami M, Old A, Popoola AA   +4 more
core   +1 more source

Serum Ubiquitin C-Terminal Hydrolase-L1, Glial Fibrillary Acidic Protein, and Neurofilament Light Chain Are Good Entry Points and Biomarker Candidates for Neurosyphilis Diagnosis Among Patients Without Human Immunodeficiency Virus to Avoid Lumbar Puncture [PDF]

, 2023
Lin Xie, Wei Li, Weiming Ye, Yao Xiao, Wujian Ke, Jianjun Niu, Tian‐Ci Yang   +6 more
openalex   +1 more source

Preventing Post-Lumbar Puncture Headache.

Annals of Emergency Medicine, 2021
E. Cognat, B. Koehl, M. Lilamand, S. Goutagny, A. Belbachir, Louise de Charentenay, T. Guiddir, P. Zetlaoui, C. Roos, C. Paquet   +9 more
semanticscholar   +1 more source

Pro‐Inflammatory c‐Met+ CD4 T Cells in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non‐inflammatory neurological disease (NIND), to ...
Gautier Breville, Mahdia Benkhoucha, Ayman Rezk, Ngoc Lan Tran, Isis Senoner, Amit Bar‐Or, Patrice H. Lalive   +6 more
wiley   +1 more source

A horizontal and perpendicular interlaminar approach for intrathecal nusinersen injection in patients with spinal muscular atrophy and scoliosis: an observational study

Orphanet Journal of Rare Diseases
Background Lumbar puncture is challenging for patients with scoliosis. Previous ultrasound-assisted techniques for lumbar puncture used the angle of the probe as the needle trajectory; however, reproducing the angle is difficult and increases the number ...
Chanyan Huang, Yuanjia Zhang, Daniel A. Diedrich, Jiawen Li, Wei Luo, Xu Zhao, Yuting Guo, Yijun Luo, Tao Zhang, Xuan Wang, Wenqi Huang, Ying Xiao   +11 more
doaj   +1 more source

From Diagnosis to Disease Staging: Multisite Validation of Cerebrospinal Fluid Molecular Tests in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The growing demand for personalized treatment in multiple sclerosis (MS) highlights the need for more precise biomarkers that can outperform magnetic resonance imaging and clinical assessment in patient stratification. Advances in multiplex proteomic technologies suggest that cerebrospinal fluid (CSF) analysis at MS onset may not only improve
Laura Ghezzi, Peter Kosa, Mark Greenwood, Enrique Alvarez, C.L. Freedman, Anne H. Cross, Francesca Pace, Mark S. Freedman, Joanna Kocot, Laura Piccio, Bibiana Bielekova   +10 more
wiley   +1 more source

Oral fluid supplementation for the prevention of post-dural puncture headache: A noninferiority randomized controlled trial.

PLoS ONE
Aim(s)To investigate the impact of the absence of specific advice for oral fluid intake, compared to supplementation water intake on the occurrence of post-dural puncture headache.DesignA prospective, open-label, non-inferiority, multicenter trial ...
Emmanuelle Cartron, Christelle Volteau, Maxime Leroy, Annastasia Voisine, Jérôme Emmanuel Dauvergne, Céline Ballet, Jean-Philippe Talarmin, Marie-Annick Quéau, Marylène Catinault, Emmanuelle Gazeau, Carole Haubertin, Romain Charreau, David Boutoille   +12 more
doaj   +1 more source

Management of Cerebellar Tonsillar Herniation following Lumbar Puncture in Idiopathic Intracranial Hypertension

Case Reports in Critical Care, 2015
Lumbar puncture is performed routinely for diagnostic and therapeutic purposes in idiopathic intracranial hypertension, despite lumbar puncture being classically contraindicated in the setting of raised intracranial pressure.
Kenneth R. Hoffman, Sean W. Chan, Andrew R. Hughes, Stephen J. Halcrow   +3 more
doaj   +1 more source

An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter [PDF]

, 2015
INTRODUCTION: Amyloid-β (Aβ) has been investigated as a diagnostic biomarker and therapeutic drug target. Recent studies found that cerebrospinal fluid (CSF) Aβ fluctuates over time, including as a diurnal pattern, and increases in absolute ...
Bateman, Randall J., Chen, Xia, Claassen, Jurgen A.H.R., Das, Ujjwas, Dean, Robert A., Farlow, Martin R., Forman, Mark, Fox, Gerard B., Gonzales, Celedon, Huang, Yafei, Kennedy, Matthew, Li, Jinhe, Lucey, Brendan P., Margolin, Richard, Savage, Mary J., Siemers, Eric R., Sjögren, Magnus, Slats, Diane, Slemmon, J. Randall, Soares, Holly, Tong, Gary, Verbeek, Marcel M., Waring, Jeffrey F.   +22 more
core   +1 more source