Results 81 to 90 of about 105,931 (293)

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

open access: yesAnnals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa   +6 more
wiley   +1 more source

Cerebrospinal Fluid Amyloid‐β Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy

open access: yesAnnals of Neurology, EarlyView.
Objective Accurately predicting future hemorrhagic events in patients with cerebral amyloid angiopathy (CAA) remains a major clinical challenge. It is unknown whether cerebrospinal fluid (CSF) biomarkers of amyloid‐beta (Aβ) pathology are associated with increased hemorrhage risk in this population.
Philipp Arndt   +15 more
wiley   +1 more source

A horizontal and perpendicular interlaminar approach for intrathecal nusinersen injection in patients with spinal muscular atrophy and scoliosis: an observational study

open access: yesOrphanet Journal of Rare Diseases
Background Lumbar puncture is challenging for patients with scoliosis. Previous ultrasound-assisted techniques for lumbar puncture used the angle of the probe as the needle trajectory; however, reproducing the angle is difficult and increases the number ...
Chanyan Huang   +11 more
doaj   +1 more source

A 50 year old with a rapid neuropsychiatric deterioration and choreaform movements [PDF]

open access: yes, 2017
A 50-year-old man presented acutely to the hospital with behavioural disturbance, choreiform movements and profound nihilistic delusions. He reported recent drug and alcohol abuse, and also apparent involvement in several recent criminal activities, for ...
Campbell, Stewart   +3 more
core   +1 more source

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić   +4 more
wiley   +1 more source

An animal model study of simplified optical navigation system-assisted percutaneous lumbar transforaminal puncture

open access: yesJournal of Orthopaedic Surgery and Research
Background Optical navigation systems can provide real-time visualization of the positional relationship between surgical instruments and patient anatomy, making them suitable for assisting in puncture localization during percutaneous transforaminal ...
B. N. Wenxiu Chai   +3 more
doaj   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić   +4 more
wiley   +1 more source

Oral fluid supplementation for the prevention of post-dural puncture headache: A noninferiority randomized controlled trial.

open access: yesPLoS ONE
Aim(s)To investigate the impact of the absence of specific advice for oral fluid intake, compared to supplementation water intake on the occurrence of post-dural puncture headache.DesignA prospective, open-label, non-inferiority, multicenter trial ...
Emmanuelle Cartron   +12 more
doaj   +1 more source

Management of Cerebellar Tonsillar Herniation following Lumbar Puncture in Idiopathic Intracranial Hypertension

open access: yesCase Reports in Critical Care, 2015
Lumbar puncture is performed routinely for diagnostic and therapeutic purposes in idiopathic intracranial hypertension, despite lumbar puncture being classically contraindicated in the setting of raised intracranial pressure.
Kenneth R. Hoffman   +3 more
doaj   +1 more source

Cost of managing meningitis and encephalitis among adult patients in the United States of America

open access: yesInternational Journal of Infectious Diseases, 2018
Objective: To determine the associated costs related to the diagnosis and treatment of meningitis and encephalitis (ME) in adult patients in the USA. Methods: A retrospective observational study design was used to assess the use and costs of diagnostic ...
J.M. Balada-Llasat   +7 more
doaj   +1 more source

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