DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord [PDF]
Biological Research, 2023 Background The biological tube is a basal biology structure distributed in all multicellular animals, from worms to humans, and has diverse biological functions. Formation of tubular system is crucial for embryogenesis and adult metabolism.
Bo Dong, Haiyan Yu, Xiuke Ouyang
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PHLPP1 regulates CFTR activity and lumen expansion through AMPK.
Development, 2022 ABSTRACT Complex organ development depends on single lumen formation and its expansion during tubulogenesis. This can be achieved by correct mitotic spindle orientation during cell division, combined with luminal fluid filling that generates hydrostatic pressure.
Lobert VH +11 more
europepmc +5 more sources
Underwater Pressure Lumen Expansion: A Novel Method to Overcome Lumen Collapse in Submucosal Endoscopy and Animal Endoscopic Full‐thickness Resection Models [PDF]
DEN OpenIn endoscopic full‐thickness resection (EFTR), luminal collapse can occur due to communication between the gastrointestinal lumen and peritoneal cavity, making visualization and procedural continuity difficult.
Hironari Shiwaku +4 more
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Midbody-Localized Aquaporin Mediates Intercellular Lumen Expansion During Early Cleavage of an Invasive Freshwater Bivalve [PDF]
Frontiers in Cell and Developmental Biology, 2022 Intercellular lumen formation is a crucial aspect of animal development and physiology that involves a complex interplay between the molecular and physical properties of the constituent cells.
Elisabeth Zieger +5 more
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Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2010 Lumen expansion driven by hydrostatic pressure occurs during many morphogenetic processes. Although it is well established that members of the Claudin family of transmembrane tight junction proteins determine paracellular tightness within epithelial/endothelial barrier systems, functional evidence for their role in the ...
Thomas Willnow +2 more
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Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation [PDF]
Developmental Cell, 2019 Epithelial tissues typically form lumina. In mammalian blastocysts, in which the first embryonic lumen forms, many studies have investigated how the cell lineages are specified through genetics and signaling, whereas potential roles of the fluid lumen have yet to be investigated.
François Graner +2 more
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Matrix metalloproteinase Nas15 regulates the lumen formation and expansion in Ciona notochord
Frontiers in Ecology and EvolutionLumen formation, as a key process of biological tube construction, is essential in various physiological processes such as nutrient and waste transporting, gas exchanging, and structural supporting.
Bo Dong
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Cftr controls lumen expansion and function of Kupffer’s vesicle in zebrafish [PDF]
Development (Cambridge), 2013 Regulated fluid secretion is crucial for the function of most organs. In vertebrates, the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) is a master regulator of fluid secretion. Although the biophysical properties of CFTR have been well characterized in vitro, little is known about its in vivo role during development. Here,
Michel Bagnat, Adam Navis
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Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model [PDF]
Cell Stem CellPost-implantation, the pluripotent epiblast in a human embryo forms a central lumen, paving the way for gastrulation. Osmotic pressure gradients are considered the drivers of lumen expansion across development, but their role in human epiblasts is unknown.
Vivek Shenoy +2 more
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Semaphorin 3A and 3F Promote Lumen Expansion in TIE2-Mutated Venous Malformation. [PDF]
Arterioscler Thromb Vasc BiolBACKGROUND: Venous malformations (VMs) are developmental defects of the vasculature characterized by tremendously enlarged and dysfunctional veins. Gain-of-function somatic mutations in TIE2 (endothelial tyrosine kinase receptor) have been identified as the leading driver of VM pathogenesis.
Schrenk S +4 more
europepmc +3 more sources