Results 11 to 20 of about 1,287,560 (260)
Epithelial organization and cyst lumen expansion require efficient Sec13–Sec31-driven secretion [PDF]
Journal of Cell Science, 2012 Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other matrix components requires efficient coat complex II (COPII) vesicle formation at the endoplasmic reticulum. Here, we show that suppression of the outer layer COPII component, Sec13, in zebrafish embryos results in a ...
Townley, Anna K +3 more
openaire +6 more sources
Anion translocation through an Slc26 transporter mediates lumen expansion during tubulogenesis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2013 Lumen formation is a critical event in biological tube formation, yet its molecular mechanisms remain poorly understood. Specifically, how lumen expansion is coordinated with other processes of tubulogenesis is not well known, and the role of membrane transporters in tubulogenesis during development has not been adequately ...
Ivana Bočina, Dominik Oliver
exaly +4 more sources
Coordinated Lumen Contraction and Expansion during Vulval Tube Morphogenesis in Caenorhabditis elegans [PDF]
Developmental Cell, 2012 Morphogenesis is a developmental phase during which cell fates are executed. Mechanical forces shaping individual cells play a key role during tissue morphogenesis. By investigating morphogenesis of the Caenorhabditis elegans hermaphrodite vulva, we show that the force-generating actomyosin network is differentially regulated by NOTCH and EGFR/RAS/MAPK
Matthias K Morf, Alex Hajnal
exaly +5 more sources
A model for cyst lumen expansion and size regulation via fluid secretion
Journal of Theoretical Biology, 2010 Many internal epithelial organs derive from cysts, which are tissues comprised of bent epithelial cell layers enclosing a lumen. Ion accumulation in the lumen drives water influx and consequently water accumulation and cyst expansion. Lumen-size recognition is important for the regulation of organ size. When lumen size and cyst size are not controlled,
Lutz Brusch, Elly Tanaka
exaly +4 more sources
Journal of Neuroendovascular Therapy, 2017 Purpose: We examined postoperative stent and lumen expansions after carotid artery stenting (CAS) in patients with carotid artery stenosis. Furthermore, we investigated factors influencing the stent and lumen expansions in a follow-up period.
Ichiro Nakagawa +2 more
exaly +3 more sources
PLoS Pathogens, 2019 Salmonella exploit host-derived nitrate for growth in the lumen of the inflamed intestine. The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO ...
Patrick A McLaughlin +6 more
doaj +3 more sources
Regulation by a TGFβ-ROCK-actomyosin axis secures a non-linear lumen expansion that is essential for tubulogenesis [PDF]
Development (Cambridge), 2015 Regulation of lumen growth is crucial to ensure the correct morphology, dimensions and function of a tubular structure. How this is controlled is still poorly understood. During Ciona intestinalis notochord tubulogenesis, single extracellular lumen pockets grow between pairs of cells and eventually fuse into a continuous tube.
Elsa Denker, Bo Dong
exaly +3 more sources
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion [PDF]
Nature Communications, 2014 The assembly of individual endothelial cells into multicellular tubes is a complex morphogenetic event in vascular development. Extracellular matrix cues and cell-cell junctional communication are fundamental to tube formation. Together they determine the shape of endothelial cells and the tubular structures that they ultimately form.
Hultin, Sara +14 more
openaire +5 more sources
A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion [PDF]
Journal of the American Society of Nephrology, 2015 Grainyhead transcription factors control epithelial barriers, tissue morphogenesis, and differentiation, but their role in the kidney is poorly understood. Here, we report that nephric duct, ureteric bud, and collecting duct epithelia express high levels of grainyhead-like homolog 2 (Grhl2) and that nephric duct lumen expansion is defective in Grhl2 ...
Annekatrin, Aue +11 more
openaire +3 more sources
A Novel High Content Angiogenesis Assay Reveals That Lacidipine, L-Type Calcium Channel Blocker, Induces In Vitro Vascular Lumen Expansion [PDF]
International Journal of Molecular Sciences, 2022 Ayman Al Haj Zen, Lutfiye Yıldız Ozer
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