Results 51 to 60 of about 35,552 (310)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Materials & Design, 2021 Trace amounts of heavy metal ions in the human body are essential for maintaining health. However, heavy metal ion excess or deficiency causes toxicity or disease. This study examines the sensitivity of luminescent europium complexes for the detection of
Xiaozhen Wang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Out-of-plane orientation of luminescent excitons in two-dimensional indium selenide
Nature Communications, 2019 Room temperature photoluminescence of most 2D van der Waals semiconductors originate from in-plane dipoles. Here, the authors report a combination of far-field photoluminescence measurements and ab-initio calculations to demonstrate that 2D-InSe flakes ...
Mauro Brotons-Gisbert +7 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
CHIMIA, 1989 The luminescent and higher excited states of [Ru(bpy)3]2⊕ are critically discussed, and compared with new measurements in sol-gel glasses, a lead tin fluorophosphate glass (made at 280 °C), boric acid (230 °C), and polyvinylalcohol film (90 °C).
Renata Reisfeld +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
BiosensorsPrecise DNA quantification and nuclear imaging are pivotal for clinical testing, pathological diagnosis, and drug development. The detection and localization of mitochondrial DNA serve as crucial indicators of cellular health.
Xinmeng Zhang +7 more
doaj +1 more source
Optical Efficiency Measurements of Large Area Luminescent Solar Concentrators [PDF]
, 2023 Tomi K. Baikie +4 more
openalex +1 more source