Results 91 to 100 of about 78,007 (304)

Oxygen‐derived free radicals: Production, biological importance, bioimaging, and analytical detection with responsive luminescent nanoprobes

View, 2021
Oxygen‐derived free radicals (ODFRs) are partially reduced oxygen reactive intermediates in living organisms during various biological processes, such as mitochondrial respirations, enzyme‐catalyzed oxidations, and radiolysis.
Jianping Liu, Miaomiao Wu, Run Zhang, Zhi Ping Xu   +3 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Vectors bicistronically linking a gene of interest to the SV40 large T antigen in combination with the SV40 origin of replication enhance transient protein expression and luciferase reporter activity

BioTechniques, 2011
The simian virus 40 large T antigen (SVLT) induces replication of plasmids bearing the SV40 origin of replication (SV40 ori) within mammalian cells. The internal ribosomal entry site (IRES) is an element that allows for the cotranslation of proteins from
Matthew J. Mahon
doaj   +1 more source

Medical diagnostics using designed molecules with sense and logic [PDF]

, 2013
Luminescent molecules responsive to cations, anions and even small molecules can be designed with the appropriate selectivity and sensitivity for monitoring physiological and pathological levels of analytes.
Cardona, Mario, Farrugia, Kristina, Magri, David C.   +2 more
core   +1 more source

Biodegradable and Recyclable Luminescent Mixed‐Matrix‐Membranes, Hydrogels, and Cryogels based on Nanoscale Metal‐Organic Frameworks and Biopolymers

Advanced Functional Materials, EarlyView.
The study presents biodegradable and recyclable mixed‐matrix membranes (MMMs), hydrogels, and cryogels using luminescent nanoscale metal‐organic frameworks (nMOFs) and biopolymers. These bio‐nMOF‐MMMs combine europium‐based nMOFs as probes for the status of the materials with the biopolymers agar and gelatine and present alternatives to conventional ...
Moritz Maxeiner, Julian Burkhart, Kateryna Borysova, Chiara Mazzariol, Klaus Müller‐Buschbaum   +4 more
wiley   +1 more source

Ground and excited state communication within a ruthenium containing benzimidazole metallopolymer [PDF]

, 2011
Emission spectroscopy and electrochemistry has been used to probe the electronic communication between adjacent metal centres and the conjugated backbone within a family of imidazole based metallopolymer, [Ru(bpy)2(PPyBBIM)n]2+, in the ground and excited
Blakely, Cameron, Cameron, Crawford, Dahms, Darren Griffith, Dennany, Dennany, Dennany, Dennany, Dennany, Dennany, Doherty, Emmet J. O'Reilly, Forster, Francois Moser, Haas, Hogan, Holiday, Jr. Arnold, Kaneko, Kasha, Keyes, Kingsborough, Kurashina, Lynn Dennany, Lyons, McClean, Mortimer, Nishihara, O'Mullane, Ofer, Osaheni, Paul, Rehm, Robert J. Forster, Roberts, Ruff, Shardon-Noblat, Terrill, Thackeray, Tia E. Keyes, Venkatanarayanan, Vogel, Wuelfing, Xing, Zhu, Ziessel   +47 more
core   +1 more source

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

Fluorescent nanodiamonds for FRET-based monitoring of a single biological nanomotor FoF1-ATP synthase

, 2009
Color centers in diamond nanocrystals are a new class of fluorescence markers that attract significant interest due to matchless brightness, photostability and biochemical inertness.
Balasubramanian, G., Boersch, M., Erdmann, R., Jelezko, F., Reuter, R., Wrachtrup, J.   +5 more
core   +1 more source

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

Slow Dynamics in Glasses

, 2005
Minimalist theories of complex systems are broadly of two kinds: mean-field and axiomatic. So far all theories of complex properties absent from simple systems and intrinsic to glasses are axiomatic.
J. C. Phillips, R. A. Cheville, R. Bergman, W. Kob, Y. E. Lozovik   +4 more
core   +1 more source