Results 121 to 130 of about 49,910 (293)

A cautionary note on the potential pitfalls of using N-terminal truncated CD63 to label small extracellular vesicles

Scientific Reports
Small extracellular vesicles (sEV) are nanosized vesicles that facilitate intracellular communication. A significant research obstacle is the isolation of sEV devoid of non-sEV contaminants.
Elias Sulaiman, Derek M. Yellon, Sean M. Davidson   +2 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Recent Advances in Fluorescent Nanoparticles for Stimulated Emission Depletion Imaging

Biosensors
Stimulated emission depletion (STED) microscopy, as a popular super-resolution imaging technique, has been widely used in bio-structure analysis and resolving the dynamics of biological processes beyond the diffraction limit.
Liqing Qi, Songlin Liu, Jiantao Ping, Xingxing Yao, Long Chen, Dawei Yang, Yijun Liu, Chenjing Wang, Yating Xiao, Lubin Qi, Yifei Jiang, Xiaohong Fang   +11 more
doaj   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Development of a global screening system for detecting protein–protein interactions by luminescence complementation in fission yeast

Scientific Reports
Deciphering protein–protein interactions (PPIs) is crucial for a comprehensive understanding of biological processes, yet current methodologies often provide incomplete interactome maps.
Fereshteh Azadeh, Atsushi Hashimoto, Shinichi Nishimura, Manabu Arioka, Minoru Yoshida, Akihisa Matsuyama   +5 more
doaj   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues

Advanced Science, EarlyView.
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia   +6 more
wiley   +1 more source

Luminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Iodine Complexes as Sensitive Probes for Indole-Binding Proteins

, 2007
Luminescent tricarbonylrhenium(I) dipyridoquinoxaline indole complexes [Re(N−N)(CO)3(L)](CF3SO3) (N−N = dipyrido[3,2-f:2‘,3‘-h]quinoxaline (dpq), L = N-(3-pyridoyl)tryptamine (py-3-CONHC2H4-indole) (1a), N-(N-(3-pyridoyl)-6-aminohexanoyl)tryptamine (py-3-
Zhu, N, Sze, KS, Tsang, KHK, Lo, KKW
core   +1 more source

Regulating room temperature phosphorescence of carbazole quaternization pyridine in polymer through Hofmeister effect

Aggregate
Hofmeister effect is a famous physical chemistry phenomenon that was reported a hundred years ago, which firstly refers to the action of certain salts to decrease the solubility of proteins while others increase.
Runying He, Yun Yang, Qian Zhou, Shasha Chang, Yi Cheng, Xiurong Ma, Yonggang Shi, Liyan Zheng, Qiue Cao   +8 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source