Results 221 to 230 of about 85,967 (327)

Luminescent detection of DNA-binding proteins [PDF]

open access: gold, 2011
Chung‐Hang Leung   +5 more
openalex   +1 more source

Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
Necroptosis, a key driver of disease progression, holds promise for activating antitumor immunity. The optogenetically controlled necroptosis system, optoMLKL, bypasses upstream signaling, forming functional hotspots in membranes without RIPK3 phosphorylation.
Da‐Hye Jeong   +11 more
wiley   +1 more source

Emergent clusteroluminescence from nonemissive molecules. [PDF]

open access: yesNat Commun
Zhang J, Xiong Z, Zhang H, Tang BZ.
europepmc   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen   +16 more
wiley   +1 more source

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways. [PDF]

open access: yesSci Rep
Khine HEE   +14 more
europepmc   +1 more source

Mixed protein-templated luminescent metal clusters (Au and Pt) for H2O2 sensing [PDF]

open access: gold, 2013
Min Li   +4 more
openalex   +1 more source

Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
The study highlights the potential of recombinant galaxin (a coral protein) as a novel and effective biomaterial for bone regeneration. It binds to ATP synthase subunit β (ATP5B) in mouse pre‐osteoblasts, thereby causing increased ATP production and mitochondrial activity.
Fei Yu   +6 more
wiley   +1 more source

Identification and functional analysis of Wall-Associated Kinase genes in Nicotiana tabacum. [PDF]

open access: yesFront Plant Sci
Li L   +10 more
europepmc   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy