Results 231 to 240 of about 85,967 (327)

Functional Characterization of an Aldol Condensation Synthase PheG for the Formation of Hispidin from Phellinus Igniarius

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
Hispidin is a polyphenolic compound with a variety of biological activities. Herein, a new aldol condensase PheG from Phellinus igniarius (P. igniarius) can catalyze tricetolatone and 3, 4‐dihydroxybenzaldehyde to hispidin. The catalytic mechanism of nucleophilic addition of PheG is determined by MM/GBSA, density functional theory calculation, and site‐
Wanting Zhang   +11 more
wiley   +1 more source

Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two‐Photon Fluorescent Probe

open access: yesAdvanced Science, EarlyView.
A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang   +12 more
wiley   +1 more source

Luminescent Molecular Sensors for the Selective Detection of Neurodegenerative Disease Protein Pathology in CSF [PDF]

open access: bronze, 2019
Florencia A. Monge   +5 more
openalex   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

open access: yesAdvanced Science, Volume 12, Issue 16, April 24, 2025.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li   +10 more
wiley   +1 more source

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