Results 241 to 250 of about 279,339 (314)

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Four-gene Prognostic Signature and Risk of Brain Metastasis of Lung Adenocarcinoma. [PDF]

Mol Carcinog
Gong Z, Yu F, Li C, Zhao B, Wen M, Zhang S, Xu Z, Wu A, Zang R, Li Y, Li H, Song Y.   +11 more
europepmc   +1 more source

CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

Advanced Science, EarlyView.
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou, Wenli Zhao, Yihan Zhu, Hongyan Liu, Yicheng Sun, Zhengrong Gong, Xuanyi Li, Ziying Liu, Kang Wen, Yicheng Wang, Jie Ren, Ruipei Xiao, Ling Jiang, Yanfeng Hu, Enguang Bi, Xiaoyong Zhang   +15 more
wiley   +1 more source

EXOSC5: a novel biomarker for poor prognosis in lung adenocarcinoma. [PDF]

BMC Cancer
Xu J, Zhang Z, Han K, Yang Z, Guo F.
europepmc   +1 more source

Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface

Advanced Science, EarlyView.
Drop‐on‐demand printing is used to replicate the spatial compartmentalization of the breast cancer‐host interface. Hydrogel confinement affects phenotypic changes in cells at the spheroid interface that drives a two‐fold increase in chemotherapeutic resistance compared to control unconfined spheroids.
Bram G. Soliman, Peilin Tian, Jiuyu Cui, Kristopher A. Kilian, J. Justin Gooding   +4 more
wiley   +1 more source

Survival Outcomes of Esophageal Squamous Cell Carcinoma Patients Who Underwent Salvage Esophagectomy: A Literature Review and Results From Two High‐Volume Centers

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to investigate survival outcomes, the efficacy of lymph node (LN) dissection, and recurrence patterns in 69 patients who underwent R0 salvage surgery for esophageal squamous cell carcinoma. Of note, abdominal LN metastases had a negative impact on survival in our series.
Kotaro Sugawara, Koichi Yagi, Takashi Fukuda, Shoh Yajima, Daiji Oka, Yoshiyuki Miwa, Shuichiro Oya, Asami Okamoto, Raito Asaoka, Yoshifumi Baba   +9 more
wiley   +1 more source

Gene expression-based identification of prognostic markers in lung adenocarcinoma. [PDF]

PLoS One
Salomonsson A, Ehinger D, Jönsson M, Botling J, Micke P, Brunnström H, Staaf J, Planck M.   +7 more
europepmc   +1 more source

Association Between the Degree of Arterial Contact Angle and Survival in Patients With Borderline Resectable Pancreatic Cancer

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated the prognostic impact of arterial contact angle in patients with borderline resectable pancreatic cancer undergoing neoadjuvant therapy and surgery. An arterial contact angle of ≥ 90° was associated with higher R1 resection rates and worse survival outcomes.
Katsuhisa Ohgi, Ryo Ashida, Mihoko Yamada, Shimpei Otsuka, Yoshiyasu Kato, Rui Sato, Akifumi Notsu, Katsuhiko Uesaka, Teiichi Sugiura   +8 more
wiley   +1 more source

Tumor-promoting UBR4 coordinates impaired mitophagy-associated senescence and lung adenocarcinoma pathogenesis. [PDF]

Proc Natl Acad Sci U S A
Jeong D, Park SH, Kim J, Kim H, Jang Y, Koh J, Jeon YK, Tasaki T, Kwon YT, Han D, Cho SY, Lee MJ.   +11 more
europepmc   +1 more source