Results 241 to 250 of about 2,251,685 (405)
Albumin-to-D-dimer ratios: A novel prognostic factor for evaluating first-line chemotherapy efficacy in advanced lung adenocarcinoma patients
Liqun Zhang, Xing Li, Zhuo Wang, Zhiyan Zhang, Lei Zhang, Zhaoyang Liu, Lisha Zhang, Shengqian Wang, Tatiana Vitalevna Khorobrykh, Mingze He, Jiawen Xiao +10 moreopenalex +2 more sourcesFibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs
Advanced Science, EarlyView.Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng +14 morewiley +1 more sourceGenomic and transcriptomic dynamics in the stepwise progression of lung adenocarcinoma. [PDF]
Cell ResFu F, Shang J, Yan Y, Jiang H, Han H, Yuan H, Gao Z, Yang J, Gao J, Wang J, Pan Y, Lin Y, Ye T, Zhang Y, Zhang Y, Xiang J, Hu H, Cao Z, Zheng Y, Li Y, Zhang Y, Jin L, Shi L, Chen H. +23 moreeuropepmc +1 more sourcePlasma-Derived Extracellular Vesicles Convey Protein Signatures That Reflect Pathophysiology in Lung and Pancreatic Adenocarcinomas [PDF]
, 2020 Johannes F. Fahrmann, Xiangying Mao, Ehsan Irajizad, Hiroyuki Katayama, Michela Capello, Ichidai Tanaka, Taketo Kato, Ignacio I. Wistuba, Anirban Maitra, Edwin J. Ostrin, Samir Hanash, Jody V. Vykoukal +11 moreopenalex +1 more sourceFunctional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer
Advanced Science, EarlyView.A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han +15 morewiley +1 more sourcePLVAP mediates the regulation of the tumour microenvironment in early-stage lung adenocarcinoma. [PDF]
Clin Transl MedXie L, Sun M, Zheng Y, Yu Z, Kong H, Yu J, Lu S, Zhang Y, Hu J, Xin H, Zhou J, Wang X, Powell CA, Hirsch FR, Bai C, Song Y, Yin J, Yang D. +17 moreeuropepmc +1 more sourceJaagsiekte sheep retrovirus infection of lung slice cultures [PDF]
, 2015 A Abbott, A Hofacre, A Winkelmann, A Zimber, AL Payne, AY Chow, B Salaun, C Cousens, C Johnson, C Leroux, C Murgia, Charline Alleaume, Chris Cousens, CO Olsen, D Hanahan, D Salvatori, David J Griffiths, DJ Griffiths, DW Verwoerd, Esther Bijsmans, F Archer, F Sozo, F Suau, FA Jassim, G Zavala, Henny M Martineau, HM Las De, HM Martineau, HM Martineau, J Ferlay, JA Platt, Jeanie Finlayson, JF Mornex, JM Sharp, JP Scheerlinck, K Perk, KD Sutherland, L Ding, LG Dobbs, M Caporale, M Caporale, M De las Heras, M De las Heras, M Palmarini, M Palmarini, M Palmarini, M Yamashita, Mark P Dagleish, ME Placke, MJ Holland, MJ Zhu, MR Galdiero, N Karachaliou, N Maeda, N Maeda, P Hopwood, R Herbst, S Seranno de, SJ Flecknoe, SK Rai, SK Wootton, SK Wootton, SL Liu, TA Liberati, TL Yuan, V Shtilbans, WB Martin +66 morecore +1 more sourceIL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma
Advanced Science, EarlyView.Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu +16 morewiley +1 more source
