Results 41 to 50 of about 2,224,563 (253)
Acrometastasis due to Lung Adenocarcinoma
Advances in Respiratory Medicine, 2018 We are presenting a case of acrometastasis in a male patient with lung adenocarcinoma. Acrometastases accumulate for 0.1% of all metastatic bone lesions and can be the first manifestation of cancer in approximately 10% of cases. The main clinical manifestations are tenderness, intermittent pain, functional impairment, erythema, heat and swelling of the Apollonatou, V., Loukides, S., Papaioannou, A.I., Papiris, S. +3 moreopenaire +4 more sourcescircRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma
Cell Death and Disease, 2020 Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear.JunFeng Wang, Xuhai Zhao, Yanbo Wang, Fenghai Ren, Dawei Sun, Yubo Yan, Xianglong Kong, Jianlong Bu, Mengfeng Liu, Shidong Xu +9 moresemanticscholar +1 more sourceGeospatial immune variability illuminates differential evolution of lung adenocarcinoma
Nature Medicine, 2020 Remarkable progress in molecular analyses has improved our understanding of the evolution of cancer cells toward immune escape1–5. However, the spatial configurations of immune and stromal cells, which may shed light on the evolution of immune escape ...K. AbdulJabbar, S. Raza, R. Rosenthal, M. Jamal-Hanjani, S. Veeriah, A. Akarca, T. Lund, D. Moore, R. Salgado, M. Al Bakir, L. Zapata, C. Hiley, L. Officer, M. Sereno, C. Smith, S. Loi, A. Hackshaw, T. Marafioti, Sergio A. Quezada, N. Mcgranahan, J. Le Quesne, Charles Mariam John Allan Sergio A. Nicholas Rachel Crispi Swanton Jamal-Hanjani Le Quesne Hackshaw Quezada M, Charles Swanton, J. Le Quesne, Sergio A. Quezada, N. Mcgranahan, Maise Al Bakir, Y. Ngai, A. Sharp, Cristina Rodrigues, O. Pressey, Sean Smith, N. Gower, H. Dhanda, Joan Riley, L. Primrose, L. Martinson, N. Carey, J. Shaw, D. Fennell, G. Wilson, Nicolai J. Birkbak, T. Watkins, M. Escudero, A. Stewart, A. Rowan, J. Goldman, P. van Loo, R. Stone, Tamara Denner, E. Nye, S. Ward, Emilia L. Lim, S. Boeing, M. Greco, K. Litchfield, J. Nicod, C. Puttick, Katey S. S. Enfield, E. Colliver, B. Campbell, C. Abbosh, Yin Wu, M. Skrzypski, R. Hynds, A. Georgiou, M. W. Sunderland, J. Reading, K. Peggs, J. Hartley, Pat Gorman, H. Lowe, L. Ensell, V. Spanswick, A. Karamani, D. Biswas, Maryam Razaq, Stephan Beck, A. Huebner, M. Dietzen, C. Naceur-Lombardelli, M. Akther, Haoran Zhai, Nnennaya Kannu, Elizabeth Manzano, S. Bola, E. Ghorani, M. R. de Massy, Elena Hoxha, E. Hatipoglu, Stephanie Ogwuru, B. Chain, Gillian Price, S. Dubois-Marshall, K. Kerr, Shirley Palmer, Heather Cheyne, Joy Miller, K. Buchan, M. Chetty, Mohammed Khalil, V. Ezhil, V. Prakash, G. Anand, Sajid Khan, K. Lau, M. Sheaff, Peter D. Schmid, L. Lim, J. Conibear, R. Schwarz, J. Tugwood, J. Pierce, C. Dive, G. Brady, D. Rothwell, Francesca Chemi, E. Kilgour, F. Blackhall, L. Priest, M. Krebs, P. Crosbie, A. Nakas, S. Rathinam, Louise Nelson, K. Ryanna, Mohamad Tuffail, A. Bajaj, J. Brožík, Fiona Morgan, M. Kornaszewska, R. Attanoos, Haydn Adams, H. Davies, M. Carter, C. Lindsay, F. Gomes, Z. Szallasi, I. Csabai, M. Dióssy, H. Aerts, A. Kirk, M. Asif, J. Butler, Rocco Bilanca, N. Kostoulas, M. Mackenzie, M. Wilcox, S. Busacca, A. Dawson, Mark R. Lovett, M. Shackcloth, Sarah L. Feeney, Julius Asante-Siaw, J. Gosney, Angela E. Leek, Nicola Totten, Jack Davies Hodgkinson, Rachael Waddington, J. Rogan, K. Moore, W. Monteiro, H. Marshall, K. Blyth, C. Dick, A. Kidd, Eric Lim, P. De Sousa, S. Jordan, A. Rice, H. Raubenheimer, H. Bhayani, Morag Hamilton, L. Ambrose, A. Devaraj, Hema Chavan, S. Begum, A. Mani, Daniel Kaniu, Mpho Malima, S. Booth, A. Nicholson, Nádia Fernandes, Jessica E. Wallen, P. Shah, S. Danson, J. Bury, J. Edwards, Jennifer Hill, S. Matthews, Yota Kitsanta, J. Rao, S. Tenconi, L. Socci, K. Suvarna, F. Kibutu, P. Fisher, R. Young, Joanne Barker, Fiona G. Taylor, K. Lloyd, T. Light, T. Horey, D. Papadatos-Pastos, P. Russell, S. Lock, Kayleigh Gilbert, D. Lawrence, M. Hayward, N. Panagiotopoulos, Robert S George, D. Patrini, M. Falzon, E. Borg, R. Khiroya, Asia Ahmed, Magali N. Taylor, Junaid Choudhary, P. Shaw, S. Janes, Martin D. Forster, T. Ahmad, S. Lee, Javier Herrero, D. Carnell, R. Mendes, J. George, N. Navani, M. Scarci, E. Bertoja, R. Stephens, E. M. Hoogenboom, James W. Holding, S. Bandula, B. Naidu, G. Langman, Andrew Robinson, H. Bancroft, A. Kerr, S. Kadiri, C. Ferris, G. Middleton, M. Djearaman, Akshay J. Patel, C. Ottensmeier, S. Chee, Benjamin Johnson, A. Alzetani, E. Shaw, Jason Lester, Y. Summers, R. Califano, Paul Taylor, R. Shah, P. Krysiak, K. Rammohan, E. Fontaine, R. Booton, M. Evison, Stuart Moss, Juliette Novasio, L. Joseph, P. Bishop, A. Chaturvedi, H. Doran, F. Granato, Vijay Joshi, E. Smith, A. Montero, Charles Swanton, Yinyin Yuan +270 moresemanticscholar +1 more sourceAn atlas of epithelial cell states and plasticity in lung adenocarcinoma
bioRxivUnderstanding cellular processes underlying early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies1. Here we studied 246,102 single epithelial cells from 16 early-stage LUADs and 47 matched normal lung samples ...Guangchun Han, Ansam Sinjab, Zahraa Rahal, Anne M Lynch, Warapen Treekitkarnmongkol, Yuejiang Liu, Alejandra G Serrano, Jiping Feng, Ke Liang, Khaja B Khan, Wei Lu, Sharia D. Hernandez, Yunhe Liu, Xuanye Cao, E. Dai, Guangsheng Pei, Jian Hu, Camille Abaya, L. I. Gomez-Bolanos, F. Peng, Minyue Chen, E. Parra, T. Cascone, B. Sepesi, S. Moghaddam, P. Scheet, M. Negrão, J. Heymach, Mingyao Li, Stephen Dubinett, Christopher S Stevenson, Avrum E Spira, J. Fujimoto, L. Solis, I. Wistuba, Jichao Chen, Linghua Wang, H. Kadara +37 moresemanticscholar +1 more sourceGenomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma
Nature Genetics, 2020 Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality. To identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases.D. Shih, D. Shih, Naema Nayyar, Ivanna V. Bihun, Ivanna V. Bihun, I. Dagogo-Jack, C. Gill, C. Gill, Elisa Aquilanti, Elisa Aquilanti, Mia S Bertalan, Alexander Kaplan, M. D’Andrea, U. Chukwueke, F. M. Ippen, Christopher A. Alvarez-Breckenridge, Nicholas D. Camarda, Matthew Lastrapes, D. McCabe, D. McCabe, Benjamin M Kuter, B. Kaufman, B. Kaufman, M. Strickland, J. Martinez-Gutierrez, J. Martinez-Gutierrez, Deepika Nagabhushan, Magali De Sauvage, Michael D. White, Brandyn Castro, Kaitlin Hoang, Andrew Kaneb, Emily Batchelor, S. Paek, S. H. Park, M. Martinez-Lage, A. Berghoff, Parker Merrill, E. Gerstner, T. Batchelor, M. Frosch, Ryan P. Frazier, D. Borger, A. Iafrate, B. Johnson, S. Santagata, S. Santagata, M. Preusser, D. Cahill, S. Carter, P. Brastianos, P. Brastianos +51 moresemanticscholar +1 more sourceInfrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma
Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn +11 morewiley +1 more sourceXXYLT1 methylation contributes to the occurrence of lung adenocarcinoma
Medicine, 2021 Abstract Background: There is evidence that DNA methylation play major roles in lung cancer. In our previously study, C3 or f21 , also referred to as XXYLT1, rs2131877 polymorphism is associated with a reduced risk of lung adenocarcinoma. So, we explored the role of XXYLT1 methylation in lung adenocarcinoma. Zeng, Hui, Wang, Ying, Wang, Ying, Zhang, Yongjun +3 moreopenaire +2 more sourcesMachine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma
Nature Communications, 2020 Early cancer detection greatly increases the chances for successful treatment, but available diagnostics for some tumours, including lung adenocarcinoma (LA), are limited.Lin Huang, Lin Wang, Xiaomeng Hu, Sen Chen, Yunwen Tao, Haiyang Su, Jing Yang, W. Xu, V. Vedarethinam, S. Wu, Bin Liu, Xin Wan, J. Lou, Qian Wang, Kun Qian +14 moresemanticscholar +1 more sourceDammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer
Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh +8 morewiley +1 more source
