Results 31 to 40 of about 2,224,563 (253)
Comprehensive molecular profiling of lung adenocarcinoma
Nature, 2014 Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic ...Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmielecki Be, Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmielecki Be, E. Collisson, Joshua D. Campbell, Angela N. Brooks, A. Berger, William Lee, J. Chmielecki, D. Beer, L. Cope, C. Creighton, Ludmila V. Danilova, L. Ding, G. Getz, P. Hammerman, D. Neil Hayes, Bryan Hernandez, J. Herman, J. Heymach, I. Jurisica, R. Kucherlapati, D. Kwiatkowski, M. Ladanyi, Gordon Robertson, N. Schultz, R. Shen, Rileen Sinha, C. Sougnez, M. Tsao, W. Travis, J. Weinstein, D. Wigle, M. Wilkerson, Andy Chu, A. Cherniack, Angela Hadjipanayis, Mara W Rosenberg, D. Weisenberger, P. Laird, Amie Radenbaugh, Singer Ma, Joshua M. Stuart, Lauren Averett Byers, S. Baylin, R. Govindan, M. Meyerson, Mara Stacey B. Kristian Carrie Jaegil Chip Lee Eric S. Rosenberg Gabriel Cibulskis Sougnez Kim Stewart Li, S. Gabriel, K. Cibulskis, Jaegil Kim, Chip Stewart, Lee T. Lichtenstein, E. Lander, M. Lawrence, Cyriac Robert Lucinda L. Michael D. Richard K. Kai Catrin Kandoth Fulton Fulton McLellan Wilson Ye Fronick M, Cyriac Kandoth, R. Fulton, L. Fulton, M. McLellan, R. Wilson, K. Ye, Catrina C. Fronick, C. Maher, Christopher A. Miller, M. Wendl, Christopher R. Cabanski, E. Mardis, C. J. D. Creighton Wheeler, David Wheeler, Miruna Yaron S. N. Rebecca Andy Eric Noreen Ranabir Carri Balasundaram Butterfield Carlsen Chu Chuah Dhalla , M. Balasundaram, Y. Butterfield, R. Carlsen, E. Chuah, Noreen Dhalla, R. Guin, Carrie Hirst, Darlene Lee, H. Li, Michael Mayo, Richard A. Moore, A. Mungall, J. Schein, Payal Sipahimalani, Angela Tam, R. Varhol, A. Gordon Robertson, N. Wye, N. Thiessen, R. Holt, Steven J. M. Jones, M. Marra, Joshua D. Angela N. Juliann Marcin Robert C. Eran Travis Campbell Brooks Chmielecki Imielinski Onofrio Hodi, M. Imieliński, R. Onofrio, Eran Hodis, Travis Zack, E. Helman, Chandra Sekhar Pedamallu, J. Mesirov, G. Saksena, S. Schumacher, S. Carter, L. Garraway, R. Beroukhim, Angela Semin Harshad S. Angeliki Alexei Xiaojia Sahil Xin Hadjipanayis Lee Mahadeshwar Pantazi Protopopov Re, Semin Lee, Harshad S. Mahadeshwar, A. Pantazi, A. Protopopov, X. Ren, S. Seth, Xingzhi Song, Jiabin Tang, Lixing Yang, Jianhua Zhang, Peng-Chieh Chen, Michael G Parfenov, Andrew Wei Xu, Netty G Santoso, L. Chin, Peter J. Park, Katherine A. J. Shaowu Yan Elizabeth Scot Umadevi Donghui Pi Hoadley Todd Auman Meng Shi Buda Waring Veluvolu T, K. Hoadley, J. Todd Auman, S. Meng, Yan Shi, Elizabeth Buda, S. Waring, Umadevi Veluvolu, Donghui Tan, P. Mieczkowski, Corbin D. Jones, J. Simons, Matthew G. Soloway, T. Bodenheimer, S. Jefferys, J. Roach, A. Hoyle, Junyuan Wu, S. Balu, Darshan Singh, J. Prins, J. S. Marron, J. Parker, C. Perou, Jinze Liu, Leslie Ludmila Daniel J. Dennis T. Philip H. Moiz S. Davi Cope Danilova Weisenberger Maglinte Lai Bootwalla , D. Maglinte, Philip Lai, M. Bootwalla, D. J. Van Den Berg, Timothy Triche Jr, Mara Lynda Jianhua Juok Daniel David Pei William Dougla Rosenberg Chin Zhang Cho DiCara Heiman Lin Mallard, Juok Cho, D. Dicara, David I Heiman, Pei Lin, William Mallard, D. Voet, Hailei Zhang, L. Zou, M. Noble, Nils Gehlenborg, H. Thorvaldsdóttir, Marc-Danie Nazaire, J. Robinson, William B. Giovanni Barry S. Gideon Jianjiong Benjamin Ven Lee Arman Aksoy Ciriello Taylor Dresdner Gao Gross, B. Arman Aksoy, G. Ciriello, B. Taylor, Gideon Dresdner, Jianjiong Gao, Benjamin E. Gross, V. Seshan, B. Reva, Rileen Sinha, S. Onur Sumer, Nils Weinhold, Christopher Sander, Sam Singer Jingchun Amie Joshua M. Christopher C. Chri Ng Ma Zhu Radenbaugh Stuart Benz Yau Haussler, S. Ng, Jingchun Zhu, C. Benz, C. Yau, D. Haussler, P. Spellman, Matthew D. Joel S. Katherine A. Patrick K. D. Charles M. Wilkerson Parker Hoadley Kimes Neil Hayes Perou, P. K. Kimes, Bradley M. Jing Yiling Patrick Lixia Lauren Wenbin John V. Broom Wang Lu Kwok Shing Ng Diao Averett Byers Liu, B. Broom, Jing Wang, Yiling Lu, Patrick Kwok Shing Ng, L. Diao, Wenbin Liu, C. Amos, Rehan Akbani, G. Mills, Erin Joseph Kevin Scott Troy David Johanna Robert Curley Paulauskis Lau Morris Shelton Mallery Gardn, Erin E. Curley, J. Paulauskis, Kevin R Lau, S. Morris, T. Shelton, D. Mallery, J. Gardner, R. Penny, Charles Katherine Saller Tarvin, Charles Saller, Katherine Tarvin, W. Richards, Robert Ayesha Cerfolio Bryant, R. Cerfolio, A. Bryant, Daniel P. Nathan A. Carol Raymond Pennell Farver, D. Raymond, N. Pennell, C. Farver, Christine Lori Mary Nicholas Brenda Jennifer Thomas Czerwinski Huelsenbeck-Dill Iacocca Petrelli Raben, Christine Czerwinski, L. Huelsenbeck-Dill, M. Iacocca, N. Petrelli, B. Rabeno, Jennifer Brown, Thomas Bauer, Oleg Olga Daniil Olga Elena Konstantin V. Dolzhanskiy Potapova Rotin Voronina Nemirovich-Dan, O. Dolzhanskiy, O. Potapova, D. Rotin, Olga Voronina, Elena Nemirovich-Danchenko, K. Fedosenko, Anthony Madhusmita Suresh S. Gabriel Gal Behera Ramalingam Sica, A. Gal, M. Behera, S. Ramalingam, G. Sica, Douglas Jeff JoEllen Flieder Boyd Weaver, D. Flieder, J. Boyd, J. Weaver, Bernard Dang Kohl Huy Quoc Thinh, B. Kohl, Dang Huy Quoc Thinh, G. Sandusky, Hartmut Juhl, E. Duhig, Peter Edward James Beverly Kristen Dante Malcolm V. Illei Gabrielson Shin Lee Rodgers Trusty Brock, P. Illei, E. Gabrielson, James Shin, Beverly Lee, Kristen Rodgers, D. Trusty, M. Brock, Christina Eric Kimberly Antonia Travis Williamson Burks Rieger-Christ Holway Sullivan, C. Williamson, E. Burks, K. Rieger-Christ, A. Holway, T. Sullivan, Dennis A. Michael K. Farhad Wigle Asiedu Kosari, M. Asiedu, F. Kosari, William D. Natasha Maureen Valerie W. Travis Rekhtman Zakowski Rusch, N. Rekhtman, M. Zakowski, V. Rusch, Paul James Harvey Chandra Yvonne Zippile Suh Pass Goparaju Owusu-Sarpong, Paul Zippile, James Suh, H. Pass, C. Goparaju, Y. Owusu-Sarpong, John M. S. Sugy Jeremy Harmanjatinder Monique Bartlett Kodeeswaran Parfitt Sekhon Albert, John M. S. Bartlett, S. Kodeeswaran, J. Parfitt, H. Sekhon, Monique Albert, John Jerome B. Eckman Myers, J. Eckman, J. Myers, Richard Carl Carmelo Cheney Morrison Gaudioso, R. Cheney, Carl Morrison, Carmelo Gaudioso, Jeffrey A. Philip Mark Michael J. Borgia Bonomi Pool Liptay, J. Borgia, P. Bonomi, M. Pool, M. Liptay, Fedor Irina Moiseenko Zaytseva, F. Moiseenko, I. Zaytseva, Hendrik Michael Philipp A. Thomas R. Dienemann Meister Schnabel Muley, H. Dienemann, M. Meister, P. Schnabel, T. Muley, M. Peifer, Carmen Lynn Sophie Gomez-Fernandez Herbert Egea, C. Gomez-Fernandez, Lynn M. Herbert, Sophie C. Egea, Mei Leigh B. Lori Ashley William K. W. Huang Thorne Boice Hill Salazar Funkhouser Kimryn , Mei Huang, L. Thorne, L. Boice, Ashley Hill Salazar, W. Funkhouser, W. Kimryn Rathmell, Rajiv Samuel A. Sanja Frank Jill M. Dhir Yousem Dacic Schneider Siegfried, R. Dhir, S. Yousem, S. Dacic, F. Schneider, J. Siegfried, R. Hajek, Mark A. Sandra Bryan Watson McDonald Meyers, M. Watson, Sandra A. McDonald, B. Meyers, Belinda Ian A. Kwun M. Lindy Morgan Rayleen V. Clarke Yang Fong Hunter Windsor Bowman, B. Clarke, I. Yang, K. Fong, L. Hunter, M. Windsor, R. Bowman, Solange Igor Peters Letovanec, Solange Peters, I. Letovanec, K. Z. Khan, Mark A. Eric E. Deepak Ari B. Julien David A. Jensen Snyder Srinivasan Kahn Baboud Pot, M. Jensen, E. Snyder, D. Srinivasan, A. Kahn, J. Baboud, D. Pot, Kenna R. Margi Tanja John A. Liming Zhining Roy Jean Mills Shaw Sheth Davidsen Demchok Yang Wang Tarnuz, K. R. Mills Shaw, Margi Sheth, Tanja Davidsen, J. Demchok, Liming Yang, Zhining Wang, R. Tarnuzzer, Jean Claude Zenklusen, Bradley A. Heidi J. Ozenberger Sofia, B. Ozenberger, H. Sofia, William D. Richard Belinda Sanja Edwina William K. Peter C Travis Cheney Clarke Dacic Duhig Funkhouser Illei , E. Duhig +356 moresemanticscholar +1 more sourceEvolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma
Nature Communications, 2021 Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited.Meng Nie, Ke Yao, Xinsheng Zhu, Na Chen, Nan Xiao, Yi Wang, Bo Peng, LiAng Yao, Peng Li, Peng Zhang, Zeping Hu +10 moresemanticscholar +1 more sourceNon-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progression.
Cancer Discovery, 2021 Cancer evolution determines molecular and morphological intra-tumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphologically diverse ...D. Tavernari, E. Battistello, E. Dheilly, Aaron Petruzzella, Marco Mina, Jessica Sordet-Dessimoz, S. Peters, T. Krueger, D. Gfeller, Nicolò Riggi, E. Oricchio, I. Letovanec, G. Ciriello +12 moresemanticscholar +1 more sourceDeciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
Nature Communications, 2021 Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally invasive adenocarcinoma, then finally into invasive adenocarcinoma.Zhoufeng Wang, Zhe Li, K. Zhou, Chengdi Wang, Lili Jiang, Li Zhang, Ying Yang, Wenxin Luo, Wenlian Qiao, Gang Wang, Yinyun Ni, S. Dai, Tingting Guo, G. Ji, Minjie Xu, Yiying Liu, Zhixi Su, Guowei Che, Wei-min Li +18 moresemanticscholar +1 more sourcePLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma
Cell Death and Differentiation, 2021 The prerequisite function of vimentin for the epithelial–mesenchymal transition (EMT) is not clearly elucidated yet. Here, we show that vimentin phosphorylated by PLK1, triggers TGF-β-signaling, which consequently leads to metastasis and PD-L1 expression Hay-Ran Jang, Sol-bi Shin, Chang-Hyeon Kim, J. Won, Rong Xu, Daeun Kim, H. Yim +6 moresemanticscholar +1 more sourceHepatoid adenocarcinoma of the lung
Autopsy and Case Reports, 2013 Lung adenocarcinomas with a mixture of tubular or papillary pattern, sheet-like or trabecular architecture, eosinophilic cytoplasm with centrally located nuclei and alpha-fetoprotein-producing cells have been described as hepatoid adenocarcinomas.Livia Barreira Cavalcante, Aloisio Felipe-Silva, Fernando Peixoto Ferraz de Campos, João Augusto dos Santos Martines +3 moreopenaire +3 more sourcesPD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity
Genome Biology, 2021 Background Although using a blockade of programmed death-ligand 1 (PD-L1) to enhance T cell immune responses shows great promise in tumor immunotherapy, the immune-checkpoint inhibition strategy is limited for patients with solid tumors.Shuang Qu, Zichen Jiao, Geng Lu, B. Yao, Ting Wang, Weiwei Rong, Jiahan Xu, T. Fan, Xinlei Sun, Rong-jiao Yang, Jun Wang, Yongzhong Yao, Guifang Xu, Xin Yan, Tao Wang, Hongwei Liang, Ke Zen +16 moresemanticscholar +1 more sourceSTK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma
Cancer Discovery, 2018 KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) co-mutations define distinct subgroups of KRAS-mutant LUAC.F. Skoulidis, M. Goldberg, D. Greenawalt, M. Hellmann, M. Awad, J. Gainor, A. Schrock, R. Hartmaier, S. Trabucco, L. Gay, Siraj M. Ali, J. Elvin, G. Singal, J. Ross, D. Fabrizio, P. Szabo, Han Chang, A. Sasson, S. Srinivasan, S. Kirov, J. Szustakowski, P. Vitazka, R. Edwards, J. Bufill, N. Sharma, S. Ou, N. Peled, D. Spigel, H. Rizvi, E. J. Aguilar, B. Carter, J. Erasmus, D. Halpenny, A. Plodkowski, N. Long, M. Nishino, W. Denning, Ana Galán-Cobo, Haifa Hamdi, Taghreed Hirz, P. Tong, Jing Wang, J. Rodriguez-Canales, P. Villalobos, E. Parra, N. Kalhor, L. Sholl, J. Sauter, A. Jungbluth, M. Mino‐Kenudson, Roxana Azimi, Y. Elamin, Jianjun Zhang, G. Leonardi, F. Jiang, Kwok-kin Wong, J. Lee, V. Papadimitrakopoulou, I. Wistuba, V. Miller, G. Frampton, J. Wolchok, A. Shaw, P. Jänne, P. Stephens, C. Rudin, W. Geese, L. Albacker, J. Heymach +68 moresemanticscholar +1 more sourcetsRNA-5001a promotes proliferation of lung adenocarcinoma cells and is associated with postoperative recurrence in lung adenocarcinoma patients
Translational Lung Cancer Research, 2021 Background The biological role and clinical significance of transfer RNA-derived small RNAs (tsRNAs) remain largely unclear. The purpose of this study was to investigate the biological function, molecular mechanism, and clinical significance of tsRNA ...F. Hu, Y. Niu, X. Mao, Jiangtao Cui, Xiaoting Wu, C. Simone, H. Kang, Wenxin Qin, Liyan Jiang +8 moresemanticscholar +1 more source
