Results 121 to 130 of about 4,636,683 (298)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Probability of Causation for Lung Cancer After Exposure to Radon Progeny: A Comparison of Models and Data [PDF]

, 1994
The estimates of lung cancer risk due to the exposure to radon decay products are based on different data sets from underground mining and on different mathematical models that are used to fit the data.
Kunz, E., Kellerer, Albrecht M., Chmelevsky, D., Tomasek, L., Barclay, D., Placek, V.   +5 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

A Survey of the Czechoslovak Follow-up of Lung Cancer Mortality in Uranium Miners [PDF]

, 1993
The major Czechoslovak cohort of uranium miners (S-cohort) is surveyed in terms of diagrams illustrating dependences on calendar year, age, and exposure to radon and radon progeny.
Kunz, E., Kellerer, Albrecht M., Chmelevsky, D., Tomasek, L., Kellerer, A.M., Sevc, J., Placek, V., Barclay, D.   +7 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Chinese Expert Consensus on Standards of PD-L1 Immunohistochemistry Testing 
for Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2020
Chinese Anti-Cancer Association, Lung Cancer Study Group of Committee of Oncopathology, Chinese Society of Lung Cancer, Expert Group on PD-L1 Testing Consensus   +2 more
doaj   +1 more source

Community Perceptions of Executive Orders Impacting Lung Cancer Care, Research, and Mental Health

International Journal of Public Health
ObjectivesIn January 2025, federal executive orders introduced sweeping changes to healthcare, public health infrastructure, and research funding. These shifts raised concern within the lung cancer (LC) community, which depends on early detection, timely
Shanada Monestime, Bradley Newton, Joelle Fathi, Danielle Hicks, Lori Millner, Laurie Ambrose, Elridge Proctor, Chaya Estrin-Lebovic, Courtney Granville   +8 more
doaj   +1 more source

Lung Cancer [PDF]

CA: A Cancer Journal for Clinicians, 1974
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Quality of life in patients receiving platinum based chemotherapy for advanced non-small cell lung cancer. [PDF]

, 2006
Quality of life in patients receiving platinum based chemotherapy for advanced non-small cell lung cancer. Lung cancer is the cause of 34,000 deaths in the UK each year, with a five year survival rate of only 7.5%.
Leary, A.
core