Results 1 to 10 of about 135,036 (309)

An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models [PDF]

Particle and Fibre Toxicology, 2023
Background The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung.
Jenny Rissler, Madeleine Peterson Sjögren, Julia Linell, Amalia Larsson Hurtig, Per Wollmer, Jakob Löndahl   +5 more
doaj   +4 more sources

Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets [PDF]

Pharmaceutics, 2021
It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube.
Anders Nord, Doris Cunha-Goncalves, Rikard Linnér, Federico Bianco, Fabrizio Salomone, Francesca Ricci, Marta Lombardini, Massimo Micaglio, Daniele Trevisanuto, Valeria Perez-de-Sa   +9 more
doaj   +2 more sources

Lung Deposition and Inspiratory Flow Rate in Patients with Chronic Obstructive Pulmonary Disease Using Different Inhalation Devices: A Systematic Literature Review and Expert Opinion [PDF]

International Journal of COPD, 2021
Adolfo Baloira,1 Araceli Abad,2 Antonia Fuster,3 Juan Luis García Rivero,4 Patricia García-Sidro,5 Eduardo Márquez-Martín,6,7 Marta Palop,8 Néstor Soler,9 JL Velasco,10 Fernando González-Torralba11 1Complejo ...
Baloira A, Abad A, Fuster A, García Rivero JL, García-Sidro P, Márquez-Martín E, Palop M, Soler N, Velasco JL, González-Torralba F   +9 more
doaj   +2 more sources

Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination [PDF]

Acta Pharmaceutica Sinica B, 2019
Vaccination via the pulmonary route could be an attractive alternative to parenteral administration. Research towards the best site of antigen deposition within the lungs to induce optimal immune responses has conflicting results which might be dependent
Jasmine Tomar, Wouter F. Tonnis, Harshad P. Patil, Anne H. de boer, Paul Hagedoorn, Rita Vanbever, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
doaj   +2 more sources

Size-dependent retention of elongate mineral particles in human lungs: modeling and implications for risk assessment [PDF]

Frontiers in Public Health
IntroductionLung deposition of elongate amphibole particles is an important process impacting the risk of cancer. There is, however, a significant gap in scientific literature characterizing the role of particle size in the differences observed for ...
Andrey Korchevskiy, Richard Attanoos, Ann G. Wylie   +2 more
doaj   +2 more sources

Modeled Respiratory Tract Deposition of Aerosolized Oil Diluents Used in Δ9-THC-Based Electronic Cigarette Liquid Products

Frontiers in Public Health, 2021
Electronic cigarette, or vaping, products (EVP) heat liquids (“e-liquids”) that contain substances (licit or illicit) and deliver aerosolized particles into the lungs.
Anand Ranpara, Aleksandr B. Stefaniak, Kenneth Williams, Elizabeth Fernandez, Ryan F. LeBouf   +4 more
doaj   +1 more source

Deposition of Inhaled Levofloxacin in Cystic Fibrosis Lungs Assessed by Functional Respiratory Imaging

Pharmaceutics, 2021
Pulmonary infections caused by Pseudomonas aeruginosa (PA) represent the leading cause of pulmonary morbidity in adults with cystic fibrosis (CF). In addition to tobramycin, colistin, and aztreonam, levofloxacin has been approved in Europe to treat PA ...
Carsten Schwarz, Claudio Procaccianti, Benjamin Mignot, Hosein Sadafi, Nicolas Schwenck, Xabier Murgia, Federico Bianco   +6 more
doaj   +1 more source

Zinc Oxide Nanoparticles Promote YAP/TAZ Nuclear Localization in Alveolar Epithelial Type II Cells

Atmosphere, 2022
We investigated roles of Hippo signaling pathway components in alveolar type II cells (AECII) after zinc oxide nanoparticle (ZnONP) exposure. ZnONPs physicochemistry was characterized using field emission-scanning electron microscopy (FE-SEM) and energy ...
Vincent Laiman, Didik Setyo Heriyanto, Yueh-Lun Lee, Ching-Huang Lai, Chih-Hong Pan, Wei-Liang Chen, Chung-Ching Wang, Kai-Jen Chuang, Jer-Hwa Chang, Hsiao-Chi Chuang   +9 more
doaj   +1 more source

Novel Insights into Aspergillus fumigatus Pathogenesis and Host Response from State-of-the-Art Imaging of Host–Pathogen Interactions during Infection

Journal of Fungi, 2022
Aspergillus fumigatus spores initiate more than 3,000,000 chronic and 300,000 invasive diseases annually, worldwide. Depending on the immune status of the host, inhalation of these spores can lead to a broad spectrum of disease, including invasive ...
Sébastien C. Ortiz, Katie Pennington, Darren D. Thomson, Margherita Bertuzzi   +3 more
doaj   +1 more source

Co-Delivery of a High Dose of Amphotericin B and Itraconazole by Means of a Dry Powder Inhaler Formulation for the Treatment of Severe Fungal Pulmonary Infections

Pharmaceutics, 2023
Over the past few decades, there has been a considerable rise in the incidence and prevalence of pulmonary fungal infections, creating a global health problem due to a lack of antifungal therapies specifically designed for pulmonary administration ...
Salomé S. Celi, Raquel Fernández-García, Andreina I. Afonso-Urich, M. Paloma Ballesteros, Anne Marie Healy, Dolores R. Serrano   +5 more
doaj   +1 more source