Results 211 to 220 of about 1,756,909 (330)

Aerosol deposition in the lung as a biomarker in asthma and chronic obstruction

Hugo Öhrneman, Andreï Malinovschi, Gui‐Hong Cai, Magnus Svartengren, Hanna Nicklasson, Jonas Jakobsson, Per Wollmer, Jakob Löndahl   +7 more
openalex   +2 more sources

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Dose deposition and secondary particle production of carbon-12 ion beams in lung, brain, and water phantoms: a PHITS Monte Carlo study

Reygemar Larong, Clyde-Gibb Dalumpines, Ronel Pojas, Jhoana Jean Daque, Nihayah Lininding, Grema Fe Peñonal, Katherine Rustique, Henry P. Aringa, Vernie C. Convicto   +8 more
openalex   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Quantitative Evaluation of Protein Nanoparticle Aerosol Deposition in an Air–Liquid Interface (ALI) System and Comparison with In Silico Lung Deposition Modeling

Ji Hyun Lee, Hongku Lee, Mi Seong Jo, Jin Kwon Kim, Youngshang Han, Yong Taek Kwon, Kangho Ahn, Elaine M. Faustman, Il Je Yu   +8 more
openalex   +1 more source

Advancing Clinical Research

Advanced Science, EarlyView.
wiley   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Enhanced fatty acid availability rewires fibroblasts metabolism and decreases collagen deposition in lung fibrosis

Gabriela Wojcik, Anita Sahu-Osen, Pamela Waked, Juergen Gindlhuber, Ayu Hutami Syarif, Andelko Hrzenjak, Chandran Nagaraj, Anna Birnhuber, Júlia Hoffmann, Lena Mischkulnig, Ehsan Bonyadirad, Małgorzata Wygrecka, Clemens Aigner, Alberto Benazzo, Andrea Olschewski, Sander Kersten, Savério Bellusci, Leigh M. Marsh, Elie El Agha, Paul Willibald Vesely, Grażyna Kwapiszewska, Valentina Biasin   +21 more
openalex   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source