Results 191 to 200 of about 1,756,909 (330)

Lung Deposition of Extrafine Versus Nonextrafine Aerosols at Low Inhalation Flow Rates in Adult Asthma Patients: A Composition Study. [PDF]

J Aerosol Med Pulm Drug Deliv
Kupczyk M, Panek M, Sadafi H, De Backer W, Wojakiewicz M, Dębowski T.   +5 more
europepmc   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Pharmacokinetics and Lung Deposition After Administration of Inhaled Mosliciguat (BAY 1237592): Results from Randomized Phase I Studies in Healthy Men. [PDF]

Clin Pharmacokinet
Saleh S, Mundry T, Nagelschmitz J, Buetehorn U, Holzschuh S, Nikkho SM.   +5 more
europepmc   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry. [PDF]

Part Fibre Toxicol
Lizonova D, Nagarkar A, Demokritou P, Kelesidis GA.   +3 more
europepmc   +1 more source

A novel delivery system for supraglottic atomization allows increased lung deposition rates of pulmonary surfactant in newborn piglets. [PDF]

Pediatr Res, 2020
Nord A, Linner R, Milesi I, Zannin E, di Castri M, Bianco F, Dellacá RL, Cunha-Goncalves D, Perez-de-Sa V.   +8 more
europepmc   +1 more source

Variability in Flow Distribution within the Lung and Its Effects on Deposition and Clearance of Inhaled Particles in Normal and Reduced Gravity

G. Co-Investigator: Prisk, Rui Carlos Sá   +1 more
openalex   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Aerosol Deposition in the Lung in Fractional Gravity: Risk Mitigation for Lunar and Martian Habitats

G. Principal Investigator: Prisk
openalex   +1 more source