Results 111 to 120 of about 3,149,992 (309)

Early life origins of lung ageing : early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years [PDF]

, 2015
Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.; Spirometry data from two time ...
Svanes, C., Dratva, J., Norbäck D, Dan Norbäck (2143342), Villani, S., Gómez Real, Francisco, Dan Norbäck, Real, Francisco Gómez, Marco, Roberto de, Janson C, Dharmage, Shyamali C, Burdet, L., Jarvis, D, Villani S, de Marco, Roberto, Zemp, E., Accordini, Simone, Roberto de Marco, Julia Dratva, Elisabeth Zemp (142900), Accordini, S., Zemp, E, Deborah Jarvis (59834), Norbäck, D., Probst-Hensch, Nicole, Zemp, Elisabeth, Zemp, Elisabeth,, Probst-Hensch, N, Deborah Jarvis, Shyamali C. Dharmage (131486), Simona Villani, Pons, M, Joachim Heinrich (60421), Dharmage, S.C., Burdet, Luc, Luc Burdet (848789), Sunyer Deu, Jordi, Sunyer J, Accordini, Simone,, de Marco R, Dratva, Julia,, Jarvis, Deborah,, Simone Accordini (411992), Heinrich, Joachim,, Svanes, C, Marco Pons (848790), Dratva, J, Roberto de Marco (370210), Probst Hensch, Nicole, Christer Janson, Cecilie Svanes (59836), Thorarinn Gislason (508297), Heinrich, Joachim, Norbäck, Dan, Pons, M., Elisabeth Zemp, Heinrich, J., Julia Dratva (748527), Luc Burdet, Jarvis, Deborah, Villani, Simona, Nicole Probst-Hensch (520032), Real, FG, Jordi Sunyer, Dharmage SC, Villani, Simona,, Jarvis, D., de Marco, R., Dratva J, Accordini S, Pons M, Gislason, T., Probst-Hensch, N., Zemp E, Christer Janson (83414), Sunyer, J., Gislason, Thorarinn, Francisco Gómez Real (769225), Dharmage, Shyamali C.,, Real, Francisco Gomez,, Sunyer, Jordi,, Janson, Christer,, Sunyer, J, Janson, C., Thorarinn Gislason, Jarvis D, Svanes C, de Marco, Roberto,, Janson, C, Norback, D, Cecilie Svanes, Simona Villani (59831), de Marco, R, Burdet, Luc,, Pons, Marco,, Francisco Gómez Real, Real FG, Gislason, Thorarinn,, Shyamali C Dharmage, Norbäck, Dan,, Heinrich, J, Real, F.G., Simone Accordini, Joachim Heinrich, Janson, Christer, Dharmage, Shyamali C., Dratva, Julia, Jordi Sunyer (59833), Probst-Hensch N, Dharmage, SC, Pons, Marco, Sunyer, Jordi, Accordini, S, Gislason, T, Gislason T, Heinrich J, Svanes, Cecilie,, Villani, S, Probst-Hensch, Nicole,, Svanes, Cecilie, Nicole Probst-Hensch, Burdet, L, Marco Pons, Burdet L   +123 more
core   +2 more sources

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Infections in lung transplanted patients: A review

Pulmonology
Lung transplantation can improve the survival of patients with severe chronic pulmonary disorders. However, the short- and long-term risk of infections can increase morbidity and mortality rates.A non-systematic review was performed to provide the most ...
M. Dettori, N. Riccardi, D. Canetti, R.M. Antonello, A.F. Piana, A. Palmieri, P. Castiglia, A.A. Azara, M.D. Masia, A. Porcu, G.C. Ginesu, M.L. Cossu, M. Conti, P. Pirina, A. Fois, I. Maida, G. Madeddu, S. Babudieri, L. Saderi, G. Sotgiu   +19 more
doaj   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Pneumocystis jirovecii is a potential pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly

Communications Biology
Early life gut microbiota is being increasingly recognized as a major contributor to short and/or long-term human health and diseases. However, little is known about these early-life events in the human microbiome of the lower respiratory tract.
Fabien Magne, Susana Ruiz-Ruiz, Vicente Pérez-Brocal, Carolina A. Ponce, Rebeca Bustamante, Viviana San Martin, Mireya Gutierrez, Gianna Gatti, Sergio L. Vargas, Andrés Moya   +9 more
doaj   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Respiratory profile of pediatric patients undergoing hematopoietic stem cell transplantation studied by oscillometry – A TRANSPIRE cohort

Pediatric Investigation, EarlyView.
These are results from a multi‐center collaboration between four large pediatric institutions, investigating baseline respiratory system function in a cohort of children undergoing hematopoietic stem cell transplantation. This manuscript proposes respiratory oscillometry as a novel way to prospectively follow lung function in these children.
Maureen B. Parenti, Julian Allen, Lisa R. Young, Heather Boas, Jason Freedman, Christopher Towe, Jane Koo, Kasiani Myers, Jason C. Woods, Adam Lane, Jonathan Gaffin, Wai Wong, Leslie Lehmann, Fernando Urrego, Gabriel Salinas Cisneros, Matthew F. Abts, K. Scott Baker, Manuel Silva‐Carmona, Erin Doherty, Paul D. Robinson, Margaret MacMillan, Stella M. Davies, Samuel B. Goldfarb   +22 more
wiley   +1 more source