Results 121 to 130 of about 690,948 (299)

Efficacy of Antimicrobial Silver‐Plated Dressings Compared to Usual Care in Preventing Left Ventricular Assist Device Driveline Infections

Artificial Organs, EarlyView.
Integrating silver‐plated wound dressings into DLES care presents a safe and effective strategy for DLI prevention. Key findings include a 100% infection‐free rate in the Silverlon group, no NPWT and hospital readmission in the Silverlon group, and no severe DESTINE stages (3, 4) in the Silverlon group.
Barbara Veiter, Martina Socha, Christiane Marko, Nesibe Seyda Colak, Alexandra Kuhn, Hebe Al Asadi, Julia Riebandt, Roxana Moayedifar, Daniel Zimpfer, Thomas Schlöglhofer   +9 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient

Current Medical Mycology, 2016
Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex.
Setareh Mamishi, Kamiar Zomorodian, Farshid Saadat, Seyedeh Zohreh Jalali, Mohsen Geramishoar   +4 more
doaj  

Bacterial Granulomatous Lung Diseases: Radiological Findings and Differential Diagnosis

Infectious Disease Reports
Background Granulomatous lung diseases include a spectrum of disorders, both infectious and noninfectious, unified by the presence of granulomas in the lung parenchyma.
Picchi Stefano Giusto, Minieri Augusto, Lassandro Francesco, Russo Giuseppe, Lassandro Giulia   +4 more
doaj   +1 more source

Epidemiology and risk factors of invasive pulmonary fungal disease in patients with lung cancer

Cancer Epidemiology
Patients with lung cancer exhibit heightened susceptibility to invasive pulmonary fungal diseases (IPFD) due to malignancy-associated immunosuppression. Current data on the pathogen distribution profile of IPFD in this population remain limited. This study investigated the epidemiological distribution of fungal pathogens causing IPFD in patients with ...
Lijuan, Wang, Kaiyao, Jiang, Meiyu, Qu, Zhiying, Hao, Yan, Song, Ruigang, Hou   +5 more
openaire   +2 more sources

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, EarlyView.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Allogeneic Hematopoietic Stem Cell Transplantation Despite Severe Fusarium solani Infection in a Lung Transplanted Patient—A Case Report

Microorganisms
Solid-organ transplant patients require prolonged immunosuppression, increasing their risk of hematologic disorders. For these conditions, allogeneic hematopoietic stem cell transplantation (HSCT) is a potential treatment, but it carries significant risk
Monica Tozzi, Adele Santoni, Marta Franceschini, Margherita Malchiodi, Irene Bernareggi, Beatrice Esposito Vangone, Corrado Zuanelli Brambilla, Elisabetta Zappone, Mariapia Lenoci, Francesca Toraldo, Valeria Del Re, Alice Pietrini, Elena Marchini, Antonella Fossi, David Bennett, Elena Bargagli, Giuseppe Marotta, Alessandro Bucalossi, Monica Bocchia   +18 more
doaj   +1 more source

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, EarlyView.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

AI‐Assisted Fungal Detection in Dermatopathology: A Study on Accuracy, Efficiency, and Usability

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives AI‐based image analysis is increasingly applied in pathology. Excluding fungal elements in PAS‐stained skin sections is labor‐intensive and well suited for AI assistance. While fungal detection in nails has been studied, skin‐biopsy applications and real‐world benefit remain limited.
Paul Schmidle, Tobias Lang, Sebastian Springenberg, Diego Calvopiña, Theresa Köhler, Valentina Getova, Ana‐Maria Gebing, Sonja Hetzer, Johanna Pierrone, Valentin Aebischer, Dieter Metze, Almut Böer‐Auer, Stephan Alexander Braun   +12 more
wiley   +1 more source

Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

European Journal of Haematology, EarlyView.
ABSTRACT Objective This study aimed to evaluate the feasibility and safety of venetoclax as a cytoreductive strategy during induction therapy in newly diagnosed acute promyelocytic leukemia (APL), and to provide an exploratory description of its early efficacy.
Yu Wang, Rong Xiao, Xiaobing Huang, Yi Xiao   +3 more
wiley   +1 more source