Results 221 to 230 of about 674,704 (375)

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, EarlyView.
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong, Xintong Xie, Juan Wu, Xiangyu Wang, Wenxiang Zhang, Shuowen Wang, Daria Valerievna Abbasova, Yi Fang, Hongnan Jiang, Jidong Gao, Jing Wang   +10 more
wiley   +1 more source

Cystic Lung Phantom to Validate Clinical CT Protocols [PDF]

arXiv
In CT-based evaluation of the extent of cystic changes in the lungs of patients with cystic lung diseases, such as Lymphangioleiomyomatosis (LAM), there is a lack of a lung phantom containing air-filled cavities that mimic pulmonary cysts to calibrate the measurement of cystic volumes from CT scans.
arxiv  

Coronary Artery Vasculopathy in a Cohort of Heart Transplant Recipients: A Single Center Experience

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary allograft vasculopathy (CAV) is a significant cause of late mortality in heart transplant recipients. This study assesses the development of CAV, associated rejection rates, and the potential impact of percutaneous coronary intervention (PCI) on survival in a cohort of heart transplant patients.
Hussein Krayem, Omar Khalil, Nayef Abouzaki, Richard Cooke, Issa Kutkut   +4 more
wiley   +1 more source

Family history of pulmonary fibrosis impacts prognosis in patients with sarcoidosis

ERJ Open Research
Thomas Planté-Bordeneuve, Michelle Terwiel, Joanne J. van der Vis, Wouter van Es, Marcel Veltkamp, Jan C. Grutters, Coline H.M. van Moorsel   +6 more
doaj   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Holistic classification of CT attenuation patterns for interstitial lung diseases via deep convolutional neural networks

Comput. methods Biomech. Biomed. Eng. Imaging Vis., 2018
Mingchen Gao, Ulas Bagci, Le Lu, Aaron Wu, Mario Buty, Hoo-Chang Shin, H. Roth, G. Papadakis, A. Depeursinge, R. Summers, Ziyue Xu, D. Mollura   +11 more
semanticscholar   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

A Genetic Twist: Cytologic Evaluation of Pancreatic Adenocarcinoma and Steatohepatitic Hepatocellular Carcinoma in a Patient With a Rare POLE Mutation

Diagnostic Cytopathology, EarlyView.
ABSTRACT Mutations in the DNA polymerase epsilon (POLE) gene are associated with an increased risk of various malignancies, including colorectal and other gastrointestinal, endometrial, ovarian, breast, and brain cancers. In extremely rare cases, POLE mutations have also been associated with pancreatic and hepatobiliary carcinomas.
Lynn Messersmith, Areeba H. Rizvi, Dina El‐Rayes, Jimmie Stewart III   +3 more
wiley   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

ESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher, Roger Hodkinson, William Makis, Peter A. McCullough   +3 more
wiley   +1 more source