Results 201 to 210 of about 275,740 (301)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Pulmonary Arterial Hypertension: Recognition and Management in Primary and Acute Care Settings. [PDF]

Cureus
Ahern BJ, Fulford ST, Long D, Miller CL.
europepmc   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Non-contact lung disease classification via orthogonal frequency division multiplexing-based passive 6G integrated sensing and communication. [PDF]

Commun Med (Lond)
Buttar HM, Rahman MMU, Nawaz MW, Mian AN, Zahid A, Abbasi QH.   +5 more
europepmc   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Multimodal data-driven multitask learning for enhanced identification and classification of chronic obstructive pulmonary disease: a retrospective study. [PDF]

J Glob Health
Wu Q, Guo H, Li R, Han J, Zhang Z, Jingesi A, Kang S.   +6 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Renal tubular lysozyme in tubulointerstitial diseases and renal sarcoidosis. [PDF]

Sarcoidosis Vasc Diffuse Lung Dis
Sanada S, Sato M.
europepmc   +1 more source

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Clinical characteristics of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. [PDF]

ERJ Open Res
O'Callaghan M, Forde SH, Franciosi AN, Penugonda M, Diesler R, O'Brien H, Buikhuisen W, Almeamar H, Samhouri BF, Ryu JH, Veltkamp M, Manali ED, Lazaratou A, Papiris SA, Bonella F, Carr L, Cottin V, Taille C, McCormack FX, Gupta N, Strosberg J, Lococo FM, Harari S, Pelosi G, Papa R, Bouros D, Kolilekas L, Daniil Z, Dimeas I, Hernandez-Gonzalez F, Sellares J, Spagnolo P, Crowley RK, O' Toole D, O'Shea D, Quinn S, Murphy DJ, Fabre A, Byrne AJ, Keane MP, Fournel L, McCarthy C.   +41 more
europepmc   +1 more source