Results 221 to 230 of about 3,148,779 (255)

Compatibility analysis of total lung capacity values measured by segmentation with computed tomography and helium dilution method. [PDF]

Ann Thorac Med
Erinc A, Kirac A, Azakli D, Kahriman B, Satici C, Cetinkaya E.   +5 more
europepmc   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Identifying Biomarkers for Chronic Obstructive Pulmonary Disease in the Salivary Metabolome. [PDF]

Int J Chron Obstruct Pulmon Dis
Asandei D, O'Shea K, Paes de Araujo R, Mironas A, Da Costa R, Asibey-Berko T, Ghosh S, Lu C, O'Rourke S, Mur LAJ, Lewis KE.   +10 more
europepmc   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Is primary care the 'right care' for respiratory medicine in Africa? [PDF]

Afr J Prim Health Care Fam Med
Mash RJ.
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

The frequent exacerbator phenotype in bronchiectasis revisited: data from EMBARC registry. [PDF]

Am J Respir Crit Care Med
Sibila O, Perea L, Burgel PR, Polverino E, Hull RC, Long MB, Chotirmall SH, Shteinberg M, Pollock J, Stobo J, Lind H, Haworth C, Dimakou K, Bossios A, Loebinger MR, Dhar R, Xu JF, Mersch P, Rademacher J, Choi H, Lorent N, Blasi F, Vendrell M, Goeminne P, Ringshausen F, De Soyza A, Aliberti S, Chalmers JD.   +27 more
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

It's more than mechanics: the case for metabolic end-points in airways disease. [PDF]

Eur Respir J
Bloom CI, Foer D, Aroda VR, Cahill KN.
europepmc   +1 more source

Open question: Can <i>Chlamydia pneumoniae</i> cause persistent infections, and how are these associated with chronic diseases? [PDF]

J Med Microbiol
Hahn DL.
europepmc   +1 more source