Results 71 to 80 of about 801,766 (352)

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Epigenetics and chromatin remodeling play a role in lung disease [PDF]

, 2011
Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA ...
Adcock, IM, Barnes, PJ, Masjedi, MR, Mortaz, E   +3 more
core   +4 more sources

Hemopexin alleviates sterile inflammation in ischemia-reperfusion-induced lung injury

Frontiers in Immunology
IntroductionPulmonary ischemia-reperfusion (IR) injury (IRI) plays a significant role in various lung disorders and is a key factor in the development of primary graft dysfunction following lung transplantation.
Tomoyuki Nakagiri, Tomoyuki Nakagiri, Nadine R. Köhler, Sabina Janciauskiene, Sabina Janciauskiene, Sabina Janciauskiene, Lavinia Neubert, Lavinia Neubert, Ann-Kathrin Knöfel, Ann-Kathrin Knöfel, Pooja Pradhan, Arjang Ruhparwar, Fabio Ius, Fabio Ius, Stephan Immenschuh   +14 more
doaj   +1 more source

Noninvasive ventilation and obstructive lung diseases [PDF]

European Respiratory Journal, 2001
The key role of noninvasive positive pressure ventilation (NPPV) is well documented in chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF) since it may avoid endotrachal intubation in >50% of cases when used as the initial treatment. However, currently only minimal data is available to assess usefulness of NPPV
J.-F. Muir, Antoine Cuvelier
openaire   +3 more sources

Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis.

Journal of Thoracic Disease, 2019
Chronic obstructive pulmonary disease (COPD) and lung cancer comprise the leading causes of lung disease-related mortality worldwide. Exposure to tobacco smoke is a mutual aetiology underlying the two diseases, accounting for almost 90% of cases.
B. Parris, H. O'Farrell, K. Fong, I. Yang   +3 more
semanticscholar   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2019
Disturbances in mitochondrial structure and function in lung epithelial cells have been implicated in the pathogenesis of various lung diseases, including chronic obstructive pulmonary disease (COPD).
M. Aghapour, A. Remels, S. D. Pouwels, D. Bruder, P. Hiemstra, S. Cloonan, I. Heijink   +6 more
semanticscholar   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. [PDF]

PLoS ONE, 2014
Airway remodeling is a pathophysiologic process at the clinical, cellular, and molecular level relating to chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma and mustard lung.
Ali Najafi, Ali Najafi, Ali Masoudi-Nejad, Mostafa Ghanei, Mohamad-Reza Nourani, Ali Moeini   +5 more
doaj   +1 more source

A cross-sectional survey investigating the desensitisation of graphic health warning labels and their impact on smokers, non-smokers and patients with COPD in a London cohort. [PDF]

, 2014
OBJECTIVES: There is a lack of evidence regarding the effectiveness of graphic health warning labels (GHWL) in different individuals, including patients with chronic obstructive pulmonary disease (COPD).
Al-Shammari, Alwan, Arndt, Australian Government, Australian Government, Bava, Bednarek, Bidwell, Britton, Coronini-Cronberg, Cunningham, Dieterich, Fong, Forey, Fritzsche, Gorecka, Greenberg, Hammond, Hammond, Hammond, Handa, Hecht, Hoek, Hoth, Isles, Kotz, Kviz, Laniado-Laborín, Leventhal, Lung, Mitchell, Moodie, Moradi, Ng, Oncken, Peto, Raupach, Rusanen, Shahab, Shinton, Sobani, Stoller, Thrasher, Tversky, UK Department of Health, Vardavas, Veer, Wakefield, Walters, Warnakulasuriya, West, Wyer   +51 more
core   +1 more source