Results 71 to 80 of about 254,670 (209)

Generation of two hiPSC lines (MHHi016-A, MHHi016-B) from a primary ciliary dyskinesia patient carrying a homozygous 5 bp duplication (c.248_252dup (p.Gly85Cysfs*11)) in exon 1 of the CCNO gene

Stem Cell Research, 2020
Cyclin O (CCNO) is involved in cell cycle regulation and mutations of CCNO are linked to the rare genetic disease primary ciliary dyskinesia (PCD).
Julia Dahlmann, Anais Sahabian, Nora Drick, Alexandra Haase, Gudrun Göhring, Nico Lachmann, Felix C. Ringshausen, Tobias Welte, Ulrich Martin, Ruth Olmer   +9 more
doaj  

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections

Nature Communications, 2018
Pulmonary infections constitute a substantial health problem worldwide. Here the authors show that phagocytes similar to primitive macrophages can be generated from human induced pluripotent stem cells, by the use of industry-compatible, stirred-tank ...
Mania Ackermann, Henning Kempf, Miriam Hetzel, Christina Hesse, Anna Rafiei Hashtchin, Kerstin Brinkert, Juliane Wilhelmine Schott, Kathrin Haake, Mark Philipp Kühnel, Silke Glage, Constanca Figueiredo, Danny Jonigk, Katherina Sewald, Axel Schambach, Sabine Wronski, Thomas Moritz, Ulrich Martin, Robert Zweigerdt, Antje Munder, Nico Lachmann   +19 more
doaj   +1 more source

Generation of an induced pluripotent stem cell line (MHHi018-A) from a patient with Cystic Fibrosis carrying p.Asn1303Lys (N1303K) mutation

Stem Cell Research, 2020
Cystic Fibrosis (CF) is a genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which encodes for a chloride ion channel regulating the balance of salt and water across secretory epithelia.
Sylvia Merkert, Madline Schubert, Alexandra Haase, Hettie M. Janssens, Bob Scholte, Nico Lachmann, Gudrun Göhring, Ulrich Martin   +7 more
doaj  

Distributed U-net model and Image Segmentation for Lung Cancer Detection [PDF]

Until now, in the wake of the COVID-19 pandemic in 2019, lung diseases, especially diseases such as lung cancer and chronic obstructive pulmonary disease (COPD), have become an urgent global health issue. In order to mitigate the goal problem, early detection and accurate diagnosis of these conditions are critical for effective treatment and improved ...
arxiv   +1 more source

Extraction of reliable information from time-domain pressure and flow signals measured by means of forced oscillation techniques [PDF]

, 2014
This paper aims to give a proof-of-concept for the possible application of the forced oscillation lung function test to assess the viscoelastic properties of the airways and tissue.
Baleanu, Dumitru, Ionescu, Clara-Mihaela, Nigmatullin, Raoul R, Osokin, Serghei I   +3 more
core   +1 more source

Plasma levels of α1-antitrypsin-derived C-terminal peptides in PiMM and PiZZ COPD patients

ERJ Open Research, 2023
Friedemann R. Börner, Urszula Lechowicz, Sabine Wrenger, Beatriz Martinez-Delgado, Beata Olejnicka, Tobias Welte, Joanna Chorostowska-Wynimko, Michael Kiehntopf, Sabina Janciauskiene   +8 more
doaj   +1 more source

Computerized Processing and Analysis of CT Images for Developing a New Criterion in COPD Diagnosis [PDF]

Journal of Isfahan Medical School (I.U.M.S),2012; 29(174), 2016
Background: Chronic obstructive pulmonary disease (COPD) is one of the most prevalent and dangerous pulmonary diseases in the world. It is forecasted that COPD will be the third deadly disease in the future. Therefore, developing non-invasive methods for diagnosis of the disease would be helpful for physicians and patients. Methods: Based on clinical
arxiv  

Angiogenesis in Chronic Obstructive Pulmonary Disease [PDF]

, 2012
Angiogenesis is a crucial component of lung pathophysiology, not only in cancer but also in other disorders, such as chronic obstructive pulmonary disease (COPD).
Alessandro Matarese, Gaetano Santulli
core   +2 more sources

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways

Journal of Immunotoxicology
This work focuses on the need for modeling and predicting adverse outcomes in immunotoxicology to improve nonclinical assessments of the safety of immunomodulatory therapies.
Alexander Mazein, Muhammad Shoaib, Miriam Alb, Christina Sakellariou, Charline Sommer, Katherina Sewald, Kristin Reiche, Patricia Gogesch, Luise A. Roser, Samira Ortega Iannazzo, Sapna Sheth, Susanne Schiffmann, Zoe Waibler, Vanessa Neuhaus, Susann Dehmel, Venkata Satagopam, Reinhard Schneider, Marek Ostaszewski, Wei Gu   +18 more
doaj   +1 more source

Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 Exacerbations

Cells, 2020
The preservation of cellular homeostasis requires the synthesis of new proteins (proteostasis) and organelles, and the effective removal of misfolded or impaired proteins and cellular debris.
Garrett Pehote, Neeraj Vij
doaj   +1 more source