Results 81 to 90 of about 275,740 (301)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Plasma levels of α1-antitrypsin-derived C-terminal peptides in PiMM and PiZZ COPD patients

ERJ Open Research, 2023
Friedemann R. Börner, Urszula Lechowicz, Sabine Wrenger, Beatriz Martinez-Delgado, Beata Olejnicka, Tobias Welte, Joanna Chorostowska-Wynimko, Michael Kiehntopf, Sabina Janciauskiene   +8 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections

Nature Communications, 2018
Pulmonary infections constitute a substantial health problem worldwide. Here the authors show that phagocytes similar to primitive macrophages can be generated from human induced pluripotent stem cells, by the use of industry-compatible, stirred-tank ...
Mania Ackermann, Henning Kempf, Miriam Hetzel, Christina Hesse, Anna Rafiei Hashtchin, Kerstin Brinkert, Juliane Wilhelmine Schott, Kathrin Haake, Mark Philipp Kühnel, Silke Glage, Constanca Figueiredo, Danny Jonigk, Katherina Sewald, Axel Schambach, Sabine Wronski, Thomas Moritz, Ulrich Martin, Robert Zweigerdt, Antje Munder, Nico Lachmann   +19 more
doaj   +1 more source

ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases [PDF]

, 2019
The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects.
Aguilaniu, Armstrong, Asterios Kampouras, Beaver, Bell, Borg, Boyce, Campbell, Causer, Chris Burtin, Clark, Corra, Cranston, Crisafulli, Daniel Langer, Danilo Berton, Dillard, Dimitris Kontopidis, Dionne C.W. Braeken, Don S. Urquhart, Ernst Eber, Evans, Farley, Frits M.E. Franssen, Georgios Kaltsakas, Gift, Grant, Grenvik, Groepenhoff, Hartman, Hebestreit, Hebestreit, Helge Hebestreit, Holm, Huszczuk, Ioannis Vogiatzis, J. Alberto Neder, Jana De Brandt, Jeanette Boyd, Johns, Johnson, Johnson, Jones, Kor, Krahenbuhl, Loe, Martijn A. Spruit, McArdle, Miller, Milo A. Puhan, Miyamura, Myers, Nagle, Naughton, Ochmann, Orenstein, Palange, Peveler, Pierantonio Laveneziana, Porszasz, Richard Casaburi, Riddell, Ries, Roberto A. Rabinovich, Roman, Saey, Samuel Verges, Sarah Crook, Sauwaluk Dacha, Schaun, Sheehan, Siler, Stickland, Thierry Troosters, Thomas Radtke, Thomy Tonia, Wagner, Ward, Wasserman, Wasserman, Whipp, Williams, Wilmore, Yeh, Yoshiya, Yvonne M.J. Goërtz, Zafeiris Louvaris, Zeballos, Zhang   +88 more
core   +5 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Treatment of cardiomyopathy with PAP therapy in a patient with severe obstructive sleep apnea. [PDF]

, 2012
Obstructive sleep apnea is common in patients with heart failure. This case illustrates that treatment with PAP therapy can improve cardiac function in patients with both conditions.
Grewal, MD, Ritu G.
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Obstructive Lung Disease [PDF]

Chest, 1995
C.V. Lynn Anderson, Thiam H. Lie
openaire   +2 more sources

Long-term outcomes of dupilumab therapy in severe asthma: A retrospective, multicenter, real-world study

Journal of Allergy and Clinical Immunology: Global
Background: Dupilumab is an IL-4Rα antibody approved for treatment of severe asthma. Real-world data on the continuation and cessation patterns of dupilumab and long-term treatment efficacy are scarce.
Carlo Mümmler, MD, Alexandra Lenoir, MD, Jeremias Götschke, MD, Michael Gerckens, MD, Merle Kaiser, MD, Moritz Kayser, MD, Nora Drick, MD, Hendrik Suhling, MD, Leonie Biener, MD, Carmen Pizarro, MD, Dirk Skowasch, MD, Nikolaus Kneidinger, MD, PhD, Jürgen Behr, MD, Katrin Milger, MD   +13 more
doaj   +1 more source