Results 81 to 90 of about 801,766 (352)
Nano-based theranostics for chronic obstructive lung diseases: challenges and therapeutic potential
Expert Opinion on Drug Delivery, 2011 The major challenges in the delivery and therapeutic efficacy of nano-delivery systems in chronic obstructive airway conditions are airway defense, severe inflammation and mucous hypersecretion.
N. Vij
semanticscholar +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Exercise response to oxygen supplementation is not associated with survival in hypoxemic patients with obstructive lung disease [PDF]
, 2018 Purpose: Hypoxemia is associated with more severe lung disease and worse outcomes. In some patients with chronic obstructive lung diseases who desaturate on exertion, supplemental oxygen improves exercise capacity.
Hopkinson, NS +4 more
core +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
THE MICROBIOTA OF LOWER AIRWAYS IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASES
Журнал микробиологии, эпидемиологии и иммунобиологии, 2018 Aim. We aimed to estimate the composition and the detection frequency of bacterial species in induced sputum samples from patients with bronchial asthma (BA), chronic obstructive lung disease (COPD) and its combined phenotype (ACOS).
S. A. Mazurina +6 more
doaj +1 more source
Respiratory Research, 2023 Background Chronic respiratory diseases are disorders of the airways and other structures of the lung, and include chronic obstructive pulmonary disease (COPD), lung cancer, asthma, bronchiectasis, interstitial lung diseases, occupational lung diseases ...
Gillian Sandra Gould +8 more
doaj +1 more source
NAFLD and AATD Are Two Diseases with Unbalanced Lipid Metabolism: Similarities and Differences
Biomedicines, 2023 Non-alcoholic fatty liver disease (NAFLD) is a type of steatosis commonly associated with obesity, dyslipidemia, hypertension, and diabetes. Other diseases such as inherited alpha-1 antitrypsin deficiency (AATD) have also been related to the development ...
Sara Perez-Luz +4 more
doaj +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
U-Net-based Lung Thickness Map for Pixel-level Lung Volume Estimation of Chest X-rays [PDF]
arXiv, 2021 Purpose: We aimed to estimate the total lung volume (TLV) from real and synthetic frontal X-ray radiographs on a pixel level using lung thickness maps generated by a U-Net. Methods: 5,959 thorax X-ray computed tomography (CT) scans were retrieved from two publicly available datasets of the lung nodule analysis 2016 (n=656) and the RSNA pulmonary ...
arxiv
Comorbidities in interstitial lung diseases
European Respiratory Review, 2017 Fibrosing lung disorders include a large number of diseases with diverse behaviour. Patients can die because of the progression of their illness, remain stable or even improve after appropriate treatment has been instituted.
G. Margaritopoulos +2 more
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