Results 11 to 20 of about 1,131,539 (313)
Clinical manifestations of a new alpha‐1 antitrypsin genetic variant: Q0parma
Respirology Case Reports, 2022 Alpha‐1 antitrypsin deficiency is an autosomal, codominant disorder caused by mutations of the SERPINA1 gene. Several mutations of SERPINA1 have been described associated with the development of pulmonary emphysema and/or chronic liver disease and ...
Marina Aiello +9 more
doaj +1 more source
Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma
Biomedicines, 2022 Inhaled corticosteroids (ICS) remain the mainstay of asthma treatment, along with bronchodilators serving as control agents in combination with ICS or reliever therapy.
Luigino Calzetta +6 more
doaj +1 more source
Cells, 2022 COPD is an incurable disorder, characterized by a progressive alveolar tissue destruction and defective mechanisms of repair and defense leading to emphysema.
Luigino Calzetta +6 more
doaj +1 more source
Pharmaceutics, 2022 Despite females being more often affected by asthma than males and the prevalence of COPD rising in females, conflicting evidence exists as to whether sex may modulate the correct inhaler technique.
Luigino Calzetta +6 more
doaj +1 more source
Improving spirometry testing by understanding patient preferences
ERJ Open Research, 2021 The American Thoracic Society and European Respiratory Society commissioned a task force to update the technical standards for spirometry testing with the aim of increasing the accuracy, precision and quality of spirometry measurements and improving the ...
Barbara Johnson +3 more
doaj +1 more source
β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes
eLife, 2020 Cardiomyocyte β3-adrenoceptors (β3-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure.
Sophie Schobesberger +9 more
doaj +1 more source
Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP)
BMJ Open Respiratory Research, 2021 Introduction COVID-19 pandemic has had a huge impact on global health to date, with 5.6 million cases in the UK since its emergence. The respiratory symptoms largely mimic those of pneumonia’ with symptoms ranging from mild to severe.
James Stockley +3 more
doaj +1 more source
Respiratory Research, 2019 Introduction In Cystic Fibrosis (CF), exercise ventilatory inefficiency and dynamic hyperinflation (DH) cause exercise limitation and induce poor exercise tolerance.
Ernesto Crisafulli +12 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2023 In recent years, development of mechanical circulatory support devices has proved to be a new treatment modality, in addition to standard pharmacological therapy, for patients with heart failure or acutely depressed cardiac function.
Blanca Pamias-Lopez +3 more
doaj +1 more source
Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
Scientific Reports, 2018 The contact cardiac electrogram is derived from the extracellular manifestation of cellular action potentials and cell-to-cell communication. It is used to guide catheter based clinical procedures.
Rasheda A. Chowdhury +9 more
doaj +1 more source