Results 11 to 20 of about 1,159,013 (264)

Muscles and lungs: fatal attraction, but time for intervention

Monaldi Archives for Chest Disease, 2005
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J.C. Winck, M. Gonçalves
doaj   +1 more source

Clinical manifestations of a new alpha‐1 antitrypsin genetic variant: Q0parma

Respirology Case Reports, 2022
Alpha‐1 antitrypsin deficiency is an autosomal, codominant disorder caused by mutations of the SERPINA1 gene. Several mutations of SERPINA1 have been described associated with the development of pulmonary emphysema and/or chronic liver disease and ...
Marina Aiello, Annalisa Frizzelli, Laura Marchi, Ilaria Ferrarotti, Davide Piloni, Giovanna Pelà, Alessandro De Simoni, Lorenzo D'Aloisio, Luigino Calzetta, Alfredo Chetta   +9 more
doaj   +1 more source

Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma

Biomedicines, 2022
Inhaled corticosteroids (ICS) remain the mainstay of asthma treatment, along with bronchodilators serving as control agents in combination with ICS or reliever therapy.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Elena Pistocchini, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Stem Cell-Based Regenerative Therapy and Derived Products in COPD: A Systematic Review and Meta-Analysis

Cells, 2022
COPD is an incurable disorder, characterized by a progressive alveolar tissue destruction and defective mechanisms of repair and defense leading to emphysema.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Francesca Camardelli, Mario Cazzola, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Impact of Sex on Proper Use of Inhaler Devices in Asthma and COPD: A Systematic Review and Meta-Analysis

Pharmaceutics, 2022
Despite females being more often affected by asthma than males and the prevalence of COPD rising in females, conflicting evidence exists as to whether sex may modulate the correct inhaler technique.
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Beatrice Ludovica Ritondo, Elena Pistocchini, Paola Rogliani, Alfredo Chetta   +6 more
doaj   +1 more source

Improving spirometry testing by understanding patient preferences

ERJ Open Research, 2021
The American Thoracic Society and European Respiratory Society commissioned a task force to update the technical standards for spirometry testing with the aim of increasing the accuracy, precision and quality of spirometry measurements and improving the ...
Barbara Johnson, Irene Steenbruggen, Brian L. Graham, Courtney Coleman   +3 more
doaj   +1 more source

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

eLife, 2020
Cardiomyocyte β3-adrenoceptors (β3-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure.
Sophie Schobesberger, Peter T Wright, Claire Poulet, Jose L Sanchez Alonso Mardones, Catherine Mansfield, Andreas Friebe, Sian E Harding, Jean-Luc Balligand, Viacheslav O Nikolaev, Julia Gorelik   +9 more
doaj   +1 more source

Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP)

BMJ Open Respiratory Research, 2021
Introduction COVID-19 pandemic has had a huge impact on global health to date, with 5.6 million cases in the UK since its emergence. The respiratory symptoms largely mimic those of pneumonia’ with symptoms ranging from mild to severe.
James Stockley, Brendan Cooper, Eyas Alhuthail, Andrew Coney   +3 more
doaj   +1 more source

The value of high-resolution computed tomography (HRCT) to determine exercise ventilatory inefficiency and dynamic hyperinflation in adult patients with cystic fibrosis

Respiratory Research, 2019
Introduction In Cystic Fibrosis (CF), exercise ventilatory inefficiency and dynamic hyperinflation (DH) cause exercise limitation and induce poor exercise tolerance.
Ernesto Crisafulli, Elisabetta Teopompi, Silvia Luceri, Francesco Longo, Panagiota Tzani, Paolo Pagano, Antonella Ielpo, Chiara Longo, Marcello Di Paolo, Nicola Sverzellati, Paolo Palange, Alfredo Chetta, Giovanna Pisi   +12 more
doaj   +1 more source

Regulation of Immunoproteasome Function in the Lung [PDF]

Scientific Reports, 2015
AbstractImpaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8+  T cells that are activated by MHC I-mediated presentation of pathogen-derived ...
Keller, I.E., Vosyka, O., Takenaka, S., Kloss, A., Dahlmann, B., Willems, L.I., Verdoes, M., Overkleeft, H.S., Marcos, E., Adnot, S., Hauck, S.M., Ruppert, C., Guenther, A., Herold, S., Ohno, S., Adler, H., Eickelberg, O., Meiners, S.   +17 more
openaire   +7 more sources