Results 51 to 60 of about 12,551,552 (363)

Functional vascularized lung grafts for lung bioengineering [PDF]

Science Advances, 2017
We propose a new approach to lung regeneration by replacement of damaged epithelium with full preservation of lung vasculature.
N. Valerio Dorrello, Brandon A. Guenthart, John D. O’Neill, Jinho Kim, Katherine Cunningham, Ya-Wen Chen, Mauer Biscotti, Theresa Swayne, Holly M. Wobma, Sarah X. L. Huang, Hans-Willem Snoeck, Matthew Bacchetta, Gordana Vunjak-Novakovic   +12 more
openaire   +4 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Lung Function Testing [PDF]

, 2005
Although diagnosis always begins with a careful history and physical examination and a physician is obligated to consider more than the diseased organ, testing of lung function has become standard practice to confirm the diagnosis, evaluate the severity of respiratory impairment, assess the therapy response and follow-up patients with various cardio ...
H. Stam, R. Gosselink
openaire   +3 more sources

Lung Development Genes and Adult Lung Function

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Poor lung health in adult life may occur partly through suboptimal growth and development, as suggested by epidemiological evidence pointing to early life risk factors.Objectives: To systematically investigate the effects of lung development genes on adult lung function.Methods: Using UK Biobank data, we tested the association of 391 genes ...
Seif O. Shaheen, Charlotte H. Dean, Miguel Pereira, Matthew Hind, Matthew Hind, Peter Burney, Annah B. Wyss, Cosetta Minelli, Stephanie J. London, Laura Portas   +9 more
openaire   +5 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Effects of Long-Term Exposure to Traffic-Related Air Pollution on Lung Function in Children

Current Allergy and Asthma Reports, 2017
Lung function in early life has been shown to be an important predictor for peak lung function in adults and later decline. Reduced lung function per se is associated with increased morbidity and mortality.
E. S. Schultz, A. Litonjua, E. Mélen
semanticscholar   +1 more source

Vitamin A and lung function in CF [PDF]

Journal of Cystic Fibrosis, 2006
Laboratory evidence suggests that vitamin A could have a protective effect on respiratory status in patients with cystic fibrosis (CF). This study shows a significant correlation between serum vitamin A concentrations and every aspect of lung function tested in 38 patients with stable CF.
Aird, Fiona K., Greene, Stephen A., Ogston, Simon A., Macdonald, Thomas M., Mukhopadhyay, Somnath   +4 more
openaire   +4 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Lung clearance index in detection of post-transplant bronchiolitis obliterans syndrome

ERJ Open Research, 2019
Background Long-term outcomes after lung transplantation are often limited by the development of obliterative bronchiolitis (OB), which is clinically defined using spirometry as bronchiolitis obliterans syndrome (BOS). Lung clearance index (LCI), derived
Madeleine Driskel, Alex Horsley, Laurice Fretwell, Nigel Clayton, Mohamed Al-Aloul   +4 more
doaj   +1 more source