Results 51 to 60 of about 1,833,864 (358)

International consensus on lung function testing during the COVID-19 pandemic and beyond

ERJ Open Research, 2022
Coronavirus disease 2019 (COVID-19) has negatively affected the delivery of respiratory diagnostic services across the world due to the potential risk of disease transmission during lung function testing.
Aisling McGowan, Pierantonio Laveneziana, Sam Bayat, Nicole Beydon, P.W. Boros, Felip Burgos, Matjaž Fležar, Monika Franczuk, Maria-Alejandra Galarza, Adrian H. Kendrick, Enrico Lombardi, Jellien Makonga-Braaksma, Meredith C. McCormack, Laurent Plantier, Sanja Stanojevic, Irene Steenbruggen, Bruce Thompson, Allan L. Coates, Jack Wanger, Donald W. Cockcroft, Bruce Culver, Karl Sylvester, Frans De Jongh   +22 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Functional vascularized lung grafts for lung bioengineering [PDF]

Science Advances, 2017
We propose a new approach to lung regeneration by replacement of damaged epithelium with full preservation of lung vasculature.
N. Valerio Dorrello, Brandon A. Guenthart, John D. O’Neill, Jinho Kim, Katherine Cunningham, Ya-Wen Chen, Mauer Biscotti, Theresa Swayne, Holly M. Wobma, Sarah X. L. Huang, Hans-Willem Snoeck, Matthew Bacchetta, Gordana Vunjak-Novakovic   +12 more
openaire   +4 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Lung ultrasound in systemic sclerosis: correlation with high-resolution computed tomography, pulmonary function tests and clinical variables of disease [PDF]

, 2015
Interstitial lung disease (ILD) is a hallmark of systemic sclerosis (SSc). Although high-resolution computed tomography (HRCT) is the gold standard to diagnose ILD, recently lung ultrasound (LUS) has emerged in SSc patients as a new promising technique ...
Amoroso, Antonio, Barbano, Biagio, Barilaro, Giuseppe, Gigante, Antonietta, Giovannetti, Antonello, Lucci, Silvio, Quarta, Silvia, Rosato, Edoardo, ROSSI FANELLI, Filippo   +8 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Novel Device for Measuring Lung Function using Oscillometry [PDF]

, 2020
The forced oscillation technique (FOT) is a non-invasive means of measuring lung mechanics. Broad-band oscillations in flow are delivered to the lungs while the resultant pressure oscillations are recorded.
Bates, Jason H.T., Daphtary, Nirav, Roy, Gregory S   +2 more
core   +1 more source

Lung Function Testing [PDF]

, 2005
Although diagnosis always begins with a careful history and physical examination and a physician is obligated to consider more than the diseased organ, testing of lung function has become standard practice to confirm the diagnosis, evaluate the severity of respiratory impairment, assess the therapy response and follow-up patients with various cardio ...
H. Stam, R. Gosselink
openaire   +3 more sources

Lung Development Genes and Adult Lung Function

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Poor lung health in adult life may occur partly through suboptimal growth and development, as suggested by epidemiological evidence pointing to early life risk factors.Objectives: To systematically investigate the effects of lung development genes on adult lung function.Methods: Using UK Biobank data, we tested the association of 391 genes ...
Seif O. Shaheen, Charlotte H. Dean, Miguel Pereira, Matthew Hind, Matthew Hind, Peter Burney, Annah B. Wyss, Cosetta Minelli, Stephanie J. London, Laura Portas   +9 more
openaire   +5 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source