Results 81 to 90 of about 1,833,864 (358)

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. [PDF]

, 2017
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II
Brumwell, Alexis N, Chapman, Harold A, Driver, Ian H, Gotts, Jeffrey E, Jackson, Julia R, Kim, Thomas, Lee, Dong-Kee, Matthay, Michael A, Shannon, John M, Tan, Victor, Vaughan, Andrew E, Wei, Ying, Xi, Ying, Xu, Jianming   +13 more
core   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Evaluation of computed tomography in the diagnosis of ultrasound-proven diaphragm dysfunction

Respiratory Research
Introduction Computed tomography (CT) is routinely employed on the evaluation of dyspnea, yet limited data exist on its assessment of diaphragmatic muscle.
Pauline Lallement, Alain Boussuges, Paul Habert, Julien Bermudez, Martine Reynaud-Gaubert, Stéphane Delliaux, Fabienne Bregeon, Benjamin Coiffard   +7 more
doaj   +1 more source

Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD

International Journal of Endocrinology, 2012
In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli.
Alfredo Chetta, Dario Olivieri
doaj   +1 more source

Comparison of three-parameter kinetic model analysis to standard Patlak’s analysis in 18F-FDG PET imaging of lung cancer patients

EJNMMI Research, 2018
Background Patlak’s graphical analysis can provide tracer net influx constant (Ki) with limitation of assuming irreversible tracer trapping, that is, release rate constant (kb) set to zero.
E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan, L. Indovina   +6 more
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK [PDF]

, 2016
Background: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use.
Andreasson, Andreasson, Anyanwu, Arcasoy, Avlonitis, Avlonitis, Behrendt, Benden, Bjørk, Boffini, Boffini, Botha, Brazier, Briggs, Brown, Bury, Charmaz, Christie, Couraud, Curtis, Cypel, Cypel, Cypel, Cypel, Cypel, Cypel, De Perrot, Department of Health, Entwistle, Fielding, Fischer, Fisher, Fisher, Fisher, Fisher, Fisher, Fisher, Gibbs, Glaser, Great Britain, Haugh, Henriksen, Information Services Division, Ingemansson, International Society for Heart and Lung Transplantation, ISD Scotland, Itano, Jirsch, Joint Formulary Committee, Kaba, Kaneda, Kierans, Korovesi, Krutsinger, Lee, Littlefield, Long, Lowton, Lowton, Machuca, Martins, Mays, Moran, Naef, National Health Service, National Heart Lung and Blood Institute, National Institute for Health and Care Excellence, National Institute for Health Care Excellence, NHS Blood and Transplant, NHS Blood and Transplant, NHS Business Service Authority, Office for National Statistics, Okada, OPTUM, Orens, O’Grady, RAND Health, RAND Health Corporation, Renshaw, Roberts, Royal College of Surgeons, Sage, Sanchez, Sanchez, Schaeffer, Siebert, Steen, Steen, Taylor, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Tikkanen, TransMedics, TransMedics, UK Government Department of Constitutional Affairs, van Enckevort, Wallinder, Ware, Warnecke, Warnecke, Wierup, World Medical Organization, XVIVO Perfusion, Zych   +102 more
core   +4 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Increased expression of 5-hydroxytryptamine(2A/B) receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention [PDF]

, 2010
Background Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited responsiveness to available treatments. It is characterised by epithelial cell injury, fibroblast activation and proliferation and extracellular matrix deposition ...
Amarie, Oana Veronica, Dumitrascu, Rio, Eickelberg, Oliver, Grimminger, Friedrich, Königshoff, Melanie, Reiter, Rudolf, Schermuly, Ralph Theo, Seeger, Werner, Udalov, Sergey   +8 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source