Results 91 to 100 of about 372,374 (158)

Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues [PDF]

, 2011
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress.
Doctrow, Susan R., Fish, Brian, Hill, Richard P., Huffman, Karl D., Lazarova, Zelmira, Mahmood, Javed, Medhora, Meetha, Molthen, Robert C., Moulder, John E., Rosenthal, Rosalind A., Sonis, Stephen T., Tofilon, Philip J.   +11 more
core   +2 more sources

PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice.

PLoS ONE, 2015
Lung epithelial and endothelial cell death accompanied by inflammation contributes to hyperoxia-induced acute lung injury (ALI). Impaired resolution of ALI can promote and/or perpetuate lung pathogenesis, including fibrosis.
Narsa M Reddy, Haranatha R Potteti, Suryanarayana Vegiraju, Hsin-Jou Chen, Chandra Mohan Tamatam, Sekhar P Reddy   +5 more
doaj   +1 more source

Acute Respiratory Distress Syndrome: Role of Oleic Acid-Triggered Lung Injury and Inflammation

Mediators of Inflammation, 2015
Lung injury especially acute respiratory distress syndrome (ARDS) can be triggered by diverse stimuli, including fatty acids and microbes. ARDS affects thousands of people worldwide each year, presenting high mortality rate and having an economic impact.
Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Patrícia Burth, Mauro Velho Castro-Faria, Hugo Caire Castro-Faria-Neto   +4 more
doaj   +1 more source

Airway microbiome dysbiosis in severe pneumonia: metagenomic evidence of pathogen expansion and commensal depletion

European Journal of Medical Research
Background The pulmonary microbiome is increasingly recognized as a key determinant of pneumonia severity, yet its clinical implications remain incompletely understood.
Yuhan Wang, Yao Shen, Jie Shen, Jing Bi, Jian Xu, Tianchang Wei, Ruilan Wang, Xueling Wu, Feng Li, Jianwen Bai, Zhijun Jie, Dongni Hou, Yuanlin Song   +12 more
doaj   +1 more source

Use of pressure muscle index to predict the contribution of patient’s inspiratory effort during pressure support ventilation: a prospective physiological study

Frontiers in Medicine
BackgroundThe successful implementation of assisted ventilation depends on matching the patient’s effort with the ventilator support. Pressure muscle index (PMI), an airway pressure based measurement, has been used as noninvasive monitoring to assess the
Ran Gao, Ran Gao, Jian-Xin Zhou, Yan-Lin Yang, Shan-Shan Xu, Yi-Min Zhou, Linlin Zhang, Ming-Yue Miao   +7 more
doaj   +1 more source

Single-cell multiomics analysis reveals CTCF as a key regulator of lung morphogenesis and progenitor maintenance

Nature Communications
Lung development generates a complex tree-like architecture through proximal-distal patterning and branching morphogenesis. However, the gene regulatory programs governing embryonic lung development remain poorly understood.
Shenfei Sun, Yamei Jiang, Fujing Huang, Wei Wei, Mathias Hochgerner, Tianmin Xu, Xiaoting Wang, Kaijun Lin, Xinna Zhang, Yanli Wang, Hua He, Miao Yu, Xiaofang Tang, Xinhua Lin   +13 more
doaj   +1 more source

Cyclophosphamide-Induced Lung Injury [PDF]

Kidney International Reports, 2019
Pugh, Dan, Farrah, Tariq E, Gallacher, Peter, Kluth, David, Dhaun, Neeraj   +4 more
openaire   +3 more sources

Assessing agreement among non-invasive indicators for inspiratory effort during pressure support ventilation

Frontiers in Medicine
BackgroundDuring pressure support ventilation (PSV), the accuracy of non-invasive indicators in diagnosing high or low inspiratory effort has been validated. However, the correlation and agreement of these indicators remain unclear.
Wen-Yi Lv, Wen-Yi Lv, Shuai Liu, Linlin Zhang, Jian-Xin Zhou   +4 more
doaj   +1 more source

Ventilator-induced mediator release: role of PEEP and surfactant [PDF]

, 2002
Lung protective ventilation such as the ARDSnet low tidal volumes strategy can reduce mortality in ARDS patients. The lmowledge that an essential therapy such as mechanical ventilation on the intensive care influences patient outcome has given rise to ...
Haitsma, J.J. (Jack)
core   +2 more sources

Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19

Respiratory Research, 2021
Georgios D. Kitsios, William Bain, Nameer Al-Yousif, Radha Duttagupta, Asim A. Ahmed, Bryan J. McVerry, Alison Morris   +6 more
doaj   +1 more source