Results 41 to 50 of about 372,374 (158)

Glycolysis and acute lung injury: A review

Asian Pacific Journal of Tropical Medicine, 2023
Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium ...
Yang Yi, Jun Chen, Nan Li, Yue Huang, Jichao Peng, Xiaoran Liu   +5 more
doaj   +1 more source

Microarray meta-analysis identifies acute lung injury biomarkers in donor lungs that predict development of primary graft failure in recipients. [PDF]

PLoS ONE, 2012
To perform a meta-analysis of gene expression microarray data from animal studies of lung injury, and to identify an injury-specific gene expression signature capable of predicting the development of lung injury in humans.We performed a microarray meta ...
Pingzhao Hu, Xinchen Wang, Jack J Haitsma, Suleiman Furmli, Hussain Masoom, Mingyao Liu, Yumiko Imai, Arthur S Slutsky, Joseph Beyene, Celia M T Greenwood, Claudia dos Santos   +10 more
doaj   +1 more source

Alveolar fluid in acute respiratory distress syndrome promotes fibroblast migration: role of platelet-derived growth factor pathway [PDF]

, 2012
OBJECTIVES: Fibroblast migration is an initiating step in fibroproliferation; its involvement during acute lung injury and acute respiratory distress syndrome remains poorly understood. The aims of this study were: 1) to determine whether bronchoalveolar
A. Mailleux, B. Crestani, C. Quesnel, I. Philip, L. Bouadma, L. Nardelli, M. Dehoux, P. Piednoir, P. Soler, S. Lasocki, V. Lecon   +10 more
core   +3 more sources

Physiological effects of high-flow oxygen via endotracheal tube versus T-piece strategies during spontaneous breathing trials: a study protocol and statistical analysis for a single-centre randomised crossover study

BMJ Open
Introduction The optimal method for conducting spontaneous breathing trials (SBTs) remains a subject of ongoing debate. High-flow oxygen via endotracheal tube (HFOT) has emerged as a novel alternative for SBTs.
Jian-Xin Zhou, Hong-Liang Li, Ming-Yue Miao, Shan-Shan Xu, Rui-Zhi Zhang, Xu An, Yue-Fu Wang   +6 more
doaj   +1 more source

Protective effect of leukotriene receptor antagonist montelukast on smoking-induced lung injury in Wistar rats. [PDF]

, 2003
Increased activation of alveolar macrophage, neutrophil and mast cell has been proven in cigarette smoking (CS)-related lung disorders (CSLD). An increased production of cysteinyl-leukotrienes (LTs), which are mediators secreted from the mentioned cells,
Coskun, Senol, Ozbilgin, Kemal, Tuglu, Ibrahim, Yuksel, Hasan   +3 more
core   +1 more source

Roll with the punches: Fibroblast growth factor 10 alleviates pyroptosis of alveolar epithelial cells in different immune niches

Clinical and Translational Medicine
Background Acute respiratory distress syndrome (ARDS) is a life‐threatening condition characterized by high mortality with no specific treatments. Fibroblast growth factor 10 (FGF10) is recognized for its tissue repair and anti‐inflammatory roles in ...
Tianchang Wei, Xiaoyan Chen, Jian Xu, Weiqi Mao, Zhenlin Yang, Yuhan Wang, Yufan Li, Wenting Jin, Cuicui Chen, Cuiping Zhang, Yuanlin Song   +10 more
doaj   +1 more source

AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin

Mediators of Inflammation, 2017
Maintenance of pulmonary endothelial barrier integrity is important for reducing severity of lung injury. Lysophosphatidic acid (LPA) regulates cell motility, cytoskeletal rearrangement, and cell growth.
Junting Cai, Jianxin Wei, Shuang Li, Tomeka Suber, Jing Zhao   +4 more
doaj   +1 more source

A nomogram model based on clinical and 3D-EIT parameters for CTEPH diagnosis

Respiratory Research
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is easily misdiagnosed. Three-dimensional (3D) electrical impedance tomography (EIT) can monitor the whole-lung perfusion at the bedside.
Jian Xu, Yuhan Wang, Ying Gong, Lu Wang, Yuanlin Song, Xu Wu   +5 more
doaj   +1 more source

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]

PLoS ONE, 2008
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi   +9 more
doaj   +1 more source

Nebulized PPARγ agonists: a novel approach to augment neonatal lung maturation and injury repair in rats. [PDF]

, 2014
BackgroundBy stimulating lipofibroblast maturation, parenterally administered peroxisome proliferator-activated receptor γ (PPARγ) agonists promote lung homeostasis and injury repair in the neonatal lung.
Gong, Ming, Husain, Maleha, Husain, Sumair, Ibe, Basil, Li, Yishi, Morales, Edith, Paek, Dave, Rehan, Virender K, Sakurai, Reiko, Torday, John S   +9 more
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