Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]
, 2018 BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.
core +2 more sources
Funding Era Free Speech Theory: Applying Traditional Speech Protection to the Regulation of Anonymous Cyberspace [PDF]
, 2014 Background Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest trauma and extremity fracture ...
Andreas Seekamp +12 more
core +2 more sources
An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK [PDF]
, 2016 Background: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use.
Andreasson +102 more
core +4 more sources
Cancer Medicine, 2022 Background First‐generation epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) sometimes causes lung injury, thereby affecting survival.
Ryota Shibaki +13 more
doaj +1 more source
Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism. [PDF]
, 2019 Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined.
Beers, Michael F +10 more
core +1 more source
Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury [PDF]
, 2014 Acute lung injury is characterized by intense neutrophilic lung inflammation and increased alveolar-capillary barrier permeability leading to severe hypoxemia, and is associated with high mortality despite improvements in supportive care.
Gupta, Kushagra +2 more
core +1 more source
Effects of Different Lung Lavage Solutions on Lung Injury
Türk Yoğun Bakim Derneği Dergisi, 2011 Aim: Experimental animal studies showed that lactated Ringer solution have beneficial effects over isotonic saline solution (0.9% NaCl) for mucociliar activity and clearance of upper respiratory tract.
Hicran Gündoğdu +3 more
doaj +1 more source
Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema. [PDF]
, 2007 Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema.
Chris J. Armit +6 more
core +1 more source
Ventilator-induced Lung Injury [PDF]
Clinics in Chest Medicine, 2016 Prevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI occurs from volutrauma, barotrauma, atelectrauma, biotrauma, and shear strain. Differences in regional mechanics are important in VILI pathogenesis.
Beitler, Jeremy R +2 more
openaire +4 more sources
In vivo Detection of Hyperoxia-induced Pulmonary Endothelial Cell Death Using \u3csup\u3e99m\u3c/sup\u3eTc-Duramycin [PDF]
, 2015 Introduction 99mTc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from ...
Audi, Said H. +5 more
core +1 more source