Results 61 to 70 of about 802,787 (231)

Respiratory Mechanics, Lung Recruitability, and Gas Exchange in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome

, 2019
OBJECTIVES: Acute respiratory distress syndrome is a clinical syndrome characterized by a refractory hypoxemia due to an inflammatory and high permeability pulmonary edema secondary to direct or indirect lung insult (pulmonary and extrapulmonary form).
Gattinoni, Luciano, Massimo Cressoni, Chiumello, Davide, Cesana, Bruno Mario, Bruno Mario Cesana, Davide Chiumello, Coppola, Silvia, Froio, Sara, Sara Froio, Silvia Coppola, Matteo Brioni, Cressoni, Massimo, Marino, Antonella, Luciano Gattinoni, Brioni, Matteo, Antonella Marino   +15 more
core   +1 more source

Lung Recruitability in Severe Acute Respiratory Distress Syndrome Requiring Extracorporeal Membrane Oxygenation

, 2019
Objectives: Quantification of potential for lung recruitment may guide the ventilatory strategy in acute respiratory distress syndrome. However, there are no quantitative data on recruitability in patients with severe acute respiratory distress syndrome ...
Duncan L. A. Wyncoll, Shankar-Hari, Manu; id_orcid, Rossella Di Mussi, Laura Amado-Rodriguez, Francesco Vasques, Di Mussi, Rossella, Amado-Rodriguez, Laura, Bartolomeo, Nicola, Manu Shankar-Hari, Camporota, Luigi, Barrett, Nicholas A., Luigi Camporota, Vasques, Francesco, Nicholas A. Barrett, Glover, Guy W., Salvatore Grasso, Nicola Bartolomeo, Barnaby Sanderson, Elena V. Caricola, Sanderson, Barnaby, Grasso, Salvatore, Christopher I. S. Meadows, Caricola, Elena V., Meadows, Christopher I. S., Guy W. Glover, Wyncoll, Duncan L. A.   +25 more
core   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Potential for Lung Recruitment Maneuvers Estimated by the Cytokines in Bronchoalveolar Lavage Fluid in Acute Respiratory Distress Syndrome

Emergency Medicine International
Conclusion: Lower levels of cytokines in BALF were observed in the RM-E group. It is possible that the cytokines in BALF, especially IL-6, could be used to determine the need for RM on the basis of lung recruitability.
Minjin Shen, Jiaping Huai
doaj   +1 more source

A Novel Noninvasive Tool to Assess Recruitability During Assisted VentilationTake-Home Points

CHEST Critical Care
Background: Lung recruitability refers to the capacity of lung parenchyma to regain aeration and functional units in response to increased airway pressure.
Luca Bastia, MD, Roberta Garberi, MD, Liliana Amendolagine, MD, Emanuele Russo, MD, Tommaso Mauri, MD, Giuseppe Foti, MD, Vanni Agnoletti, MD, Emanuele Rezoagli, MD, PhD   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Lung protection : the concept

, 2013
The real triggers of Ventilator Induced Lung Injury (VILI) results from un-physiological lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio).
L. Gattinoni
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The future of mechanical ventilation: lessons from the present and the past

Critical Care, 2017
The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS) arise from two main causes: unphysiological increases of transpulmonary pressure and unphysiological increases/decreases of pleural pressure during positive or ...
Luciano Gattinoni, John J. Marini, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Tommaso Tonetti, Francesco Vasques, Michael Quintel   +7 more
doaj   +1 more source