Results 71 to 80 of about 802,787 (231)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Recruitment-to-inflation ratio reflects the impact of peep on dynamic lung strain in a highly recruitable model of ARDS

Annals of Intensive Care
Background The recruitment-to-inflation ratio (R/I) has been recently proposed to bedside assess response to PEEP. The impact of PEEP on ventilator-induced lung injury depends on the extent of dynamic strain reduction.
Francesco Murgolo, Domenico L. Grieco, Savino Spadaro, Nicola Bartolomeo, Rossella di Mussi, Luigi Pisani, Marco Fiorentino, Alberto Maria Crovace, Luca Lacitignola, Francesco Staffieri, Salvatore Grasso   +10 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Early life origins of lung ageing : early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years [PDF]

, 2015
Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.; Spirometry data from two time ...
Svanes, C., Dratva, J., Norbäck D, Dan Norbäck (2143342), Villani, S., Gómez Real, Francisco, Dan Norbäck, Real, Francisco Gómez, Marco, Roberto de, Janson C, Dharmage, Shyamali C, Burdet, L., Jarvis, D, Villani S, de Marco, Roberto, Zemp, E., Accordini, Simone, Roberto de Marco, Julia Dratva, Elisabeth Zemp (142900), Accordini, S., Zemp, E, Deborah Jarvis (59834), Norbäck, D., Probst-Hensch, Nicole, Zemp, Elisabeth, Zemp, Elisabeth,, Probst-Hensch, N, Deborah Jarvis, Shyamali C. Dharmage (131486), Simona Villani, Pons, M, Joachim Heinrich (60421), Dharmage, S.C., Burdet, Luc, Luc Burdet (848789), Sunyer Deu, Jordi, Sunyer J, Accordini, Simone,, de Marco R, Dratva, Julia,, Jarvis, Deborah,, Simone Accordini (411992), Heinrich, Joachim,, Svanes, C, Marco Pons (848790), Dratva, J, Roberto de Marco (370210), Probst Hensch, Nicole, Christer Janson, Cecilie Svanes (59836), Thorarinn Gislason (508297), Heinrich, Joachim, Norbäck, Dan, Pons, M., Elisabeth Zemp, Heinrich, J., Julia Dratva (748527), Luc Burdet, Jarvis, Deborah, Villani, Simona, Nicole Probst-Hensch (520032), Real, FG, Jordi Sunyer, Dharmage SC, Villani, Simona,, Jarvis, D., de Marco, R., Dratva J, Accordini S, Pons M, Gislason, T., Probst-Hensch, N., Zemp E, Christer Janson (83414), Sunyer, J., Gislason, Thorarinn, Francisco Gómez Real (769225), Dharmage, Shyamali C.,, Real, Francisco Gomez,, Sunyer, Jordi,, Janson, Christer,, Sunyer, J, Janson, C., Thorarinn Gislason, Jarvis D, Svanes C, de Marco, Roberto,, Janson, C, Norback, D, Cecilie Svanes, Simona Villani (59831), de Marco, R, Burdet, Luc,, Pons, Marco,, Francisco Gómez Real, Real FG, Gislason, Thorarinn,, Shyamali C Dharmage, Norbäck, Dan,, Heinrich, J, Real, F.G., Simone Accordini, Joachim Heinrich, Janson, Christer, Dharmage, Shyamali C., Dratva, Julia, Jordi Sunyer (59833), Probst-Hensch N, Dharmage, SC, Pons, Marco, Sunyer, Jordi, Accordini, S, Gislason, T, Gislason T, Heinrich J, Svanes, Cecilie,, Villani, S, Probst-Hensch, Nicole,, Svanes, Cecilie, Nicole Probst-Hensch, Burdet, L, Marco Pons, Burdet L   +123 more
core   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: results of a prospective, randomized international trial in lung transplantation.

, 2012
Chronic lung allograft dysfunction, which manifests as bronchiolitis obliterans syndrome (BOS), is recognized as the primary cause of morbidity and mortality after lung transplantation.
Klepetko, Walter, European and Australian Investigators in Lung Transplantation, Glanville, A.R., Aubert, John-David, Knoop, C., Vettorazzi, Eik, Aubert, J.D., Aboyoun, Christina, Klepetko, W., Vettorazzi, E., Reichenspurner, H., Reichenspurner, Hermann, Treede, Hendrik, Glanville, Allan R., Knoop, Christiane, Bravo, Carlos, Lama, Raffael, Lama, R., European,, Aboyoun, C., Bravo, C., Treede, H.   +21 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Lung Recruitability Is Better Estimated According to the Berlin Definition of Acute Respiratory Distress Syndrome at Standard 5 cm H2O Rather Than Higher Positive End-Expiratory Pressure: A Retrospective Cohort Study.

, 2015
.OBJECTIVES: The Berlin definition of acute respiratory distress syndrome has introduced three classes of severity according to PaO2/FIO2 thresholds.
E. Carlesso, Cressoni M, Chiurazzi C, C. Chiurazzi, M. Lazzerini, P. Caironi, RANIERI, VITO MARCO, Bugedo G, Bottino N, Chiurazzi, Chiara, D. Chiumello, Ranieri, Marco V., Gattinoni L., O. Moerer, Caironi P, Caironi, Pietro, Carlesso E, Moerer O, Ranieri, V. Marco, Chiumello D, Carlesso, Eleonora, Bottino, Nicola, Quintel, Michael, Gattinoni, Luciano, Chiumello, Davide, V. M. Ranieri, Lazzerini, Marco, G. Bugedo, N. Bottino, Brioni M, M. Cressoni, M. Quintel, Lazzerini M, Moerer, Onner, Cressoni, Massimo, Bugedo, Guillermo, Brioni, Matteo, Quintel M, M. Brioni, Bugedo Tarraza, Guillermo, L. Gattinoni   +40 more
core   +1 more source

Bedside personalized methods based on electrical impedance tomography or respiratory mechanics to set PEEP in ARDS and recruitment-to-inflation ratio: a physiologic study

Annals of Intensive Care
Background Various Positive End-Expiratory Pressure (PEEP) titration strategies have been proposed to optimize ventilation in patients with acute respiratory distress syndrome (ARDS).
Bertrand Pavlovsky, Christophe Desprez, Jean-Christophe Richard, Nicolas Fage, Arnaud Lesimple, Dara Chean, Antonin Courtais, Tommaso Mauri, Alain Mercat, François Beloncle   +9 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source