Results 51 to 60 of about 273,336 (352)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Tuberous sclerosis complex associated lymphangioleiomyomatosis caused by de novo mutation of TSC2 gene in Vietnam: A case report

Respirology Case Reports
Lymphangioleiomyomatosis (LAM) represents a rare, insidiously progressive disease of the pulmonary system, marked by cystic degradation of lung tissues leading to respiratory compromise. Pulmonary LAM has been identified as being associated with tuberous
Dinh Van Luong, Le Ngoc Huy, Nguyen Xuan Giang, Nguyen Huu Hong Thu, Nguyen Hai Ha, Nguyen Huy Binh   +5 more
doaj   +1 more source

Gastroesophageal Reflux in Lung Transplantation

Barcelona Respiratory Network Reviews, 2023
Gastroesophageal reflux disease (GERD) in lung transplant recipients has been associated with chronic lung allograft dysfunction (CLAD). CLAD is a leading cause of mortality in lung transplant recipients, and it is probably the result of a variety of ...
Sheila Izquierdo-Cuervo, Sandra Tello-Mena, Víctor M. Mora-Cuesta   +2 more
doaj   +1 more source

Rescue Everolimus Post Lung Transplantation is Not Associated With an Increased Incidence of CLAD or CLAD-Related Mortality [PDF]

, 2023
S. Ivulich, Miranda Paraskeva, Eldho Paul, Carl M. J. Kirkpatrick, Michael Dooley, Gregory I. Snell   +5 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Impact of donor lung bacteria detected by rapid on-site evaluation on early post-transplant outcomes in lung transplant recipients

Asian Journal of Surgery
Background: Rapid On-Site Evaluation (ROSE) has been widely used in clinical applications. However, in the field of lung transplantation, there have been no comparative experiments to confirm and quantify its effectiveness.
Tianyang Liu, Yunxiang Zhang, Hang Yang, Xiaoshan Li, Hongmei Wang, Li Fan, Dong Wei, Bo Wu   +7 more
doaj   +1 more source

Regulatory and Effector Cell Disequilibrium in Patients with Acute Cellular Rejection and Chronic Lung Allograft Dysfunction after Lung Transplantation: Comparison of Peripheral and Alveolar Distribution

Cells, 2021
Background: The immune mechanisms occurring during acute rejection (AR) and chronic lung allograft dysfunction are a challenge for research and the balance between effector and regulatory cells has not been defined completely.
Laura Bergantini, Miriana d’Alessandro, Elda De Vita, Felice Perillo, Antonella Fossi, Luca Luzzi, Piero Paladini, Anna Perrone, Paola Rottoli, Piersante Sestini, Elena Bargagli, David Bennett   +11 more
doaj   +1 more source

Pediatric Lung Transplantation [PDF]

Proceedings of the American Thoracic Society, 2009
Pediatric lung transplant is a viable option for treatment of end-stage lung disease in children, with > 100 pediatric lung transplants reported to the Registry of the International Society of Heart and Lung Transplantation each year. Long-term success is limited by availability of donor organs, debilitation as a result of chronic disease, impaired ...
openaire   +3 more sources

Paediatric lung transplantation [PDF]

European Respiratory Journal, 2004
Since 1990, lung transplantation has been performed in infants, children and adolescents in small numbers, and the numbers, in comparison with adult transplants, remain small today. The indications for lung transplantation are similar in childhood when compared with adults, but the disease entities are distinct.In children, severe pulmonary vascular ...
G B, Mallory, T L, Spray
openaire   +2 more sources

Different behaviour of BK-virus infection in liver transplant recipients [PDF]

, 2016
Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts ...
MITTERHOFER, Anna Paola, Muiesan, Paolo, TINTI, FRANCESCA, UMBRO, ILARIA   +3 more
core   +3 more sources